Steroid receptor coactivator TAIMAN is a new modulator of
insect circadian clock

J 2023

Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock

SMYKAL, Vlastimil, Lenka CHODAKOVA, Marketa HEJNIKOVA, Kristína BRIEDIKOVÁ, Bulah Chia-Hsiang WU et. al.

Základní údaje

Originální název

Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock

Autoři

SMYKAL, Vlastimil, Lenka CHODAKOVA, Marketa HEJNIKOVA, Kristína BRIEDIKOVÁ (703 Slovensko, domácí), Bulah Chia-Hsiang WU, Hana VANECKOVA, Ping CHEN, Anna JANOVSKA, Pavlina KYJAKOVA, Martin VÁCHA (203 Česká republika, domácí) a David DOLEZEL (garant)

Vydání

PLoS Genetics, San Francisco, Public Library Science, 2023, 1553-7404

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10602 Biology , Evolutionary biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.500 v roce 2022

Kód RIV

RIV/00216224:14310/23:00133966

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1371/journal.pgen.1010924

UT WoS

001159590000001

Klíčová slova anglicky

Circadian rhythms; RNA interference; Larvae; Insects; Drosophila melanogaster; Hormones; Biological locomotion; Exon mapping

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 3. 2024 08:17, Mgr. Marie Šípková, DiS.

Anotace

V originále

TAIMAN (TAI), the only insect ortholog of mammalian Steroid Receptor Coactivators (SRCs), is a critical modulator of ecdysone and juvenile hormone (JH) signaling pathways, which govern insect development and reproduction. The modulatory effect is mediated by JH-dependent TAI’s heterodimerization with JH receptor Methoprene-tolerant and association with the Ecdysone Receptor complex. Insect hormones regulate insect physiology and development in concert with abiotic cues, such as photo- and thermoperiod. Here we tested the effects of JH and ecdysone signaling on the circadian clock by a combination of microsurgical operations, application of hormones and hormone mimics, and gene knockdowns in the linden bug Pyrrhocoris apterus males. Silencing taiman by each of three non-overlapping double-strand RNA fragments dramatically slowed the free-running period (FRP) to 27–29 hours, contrasting to 24 hours in controls. To further corroborate TAIMAN’s clock modulatory function in the insect circadian clock, we performed taiman knockdown in the cockroach Blattella germanica. Although Blattella and Pyrrhocoris lineages separated ~380 mya, B. germanica taiman silencing slowed the FRP by more than 2 hours, suggesting a conserved TAI clock function in (at least) some insect groups. Interestingly, the pace of the linden bug circadian clock was neither changed by blocking JH and ecdysone synthesis, by application of the hormones or their mimics nor by the knockdown of corresponding hormone receptors. Our results promote TAI as a new circadian clock modulator, a role described for the first time in insects. We speculate that TAI participation in the clock is congruent with the mammalian SRC-2 role in orchestrating metabolism and circadian rhythms, and that TAI/SRCs might be conserved components of the circadian clock in animals.

Návaznosti

QK1910286, projekt VaV

Název: Efektivní postupy a strategie pro zvládání včelích chorob a udržitelný chov včelstev

Investor: Ministerstvo zemědělství ČR, Efektivní postupy a strategie pro zvládání včelích chorob a udržitelný chov včelstev

Citovat

SMYKAL, Vlastimil, Lenka CHODAKOVA, Marketa HEJNIKOVA, Kristína BRIEDIKOVÁ, Bulah Chia-Hsiang WU, Hana VANECKOVA, Ping CHEN, Anna JANOVSKA, Pavlina KYJAKOVA, Martin VÁCHA a David DOLEZEL. Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock. PLoS Genetics. San Francisco: Public Library Science, 2023, roč. 19, č. 9, s. 1-25. ISSN 1553-7404. Dostupné z: https://dx.doi.org/10.1371/journal.pgen.1010924.

@article{2362038,
   author = {Smykal, Vlastimil and Chodakova, Lenka and Hejnikova, Marketa and Briediková, Kristína and Wu, Bulah ChiaandHsiang and Vaneckova, Hana and Chen, Ping and Janovska, Anna and Kyjakova, Pavlina and Vácha, Martin and Dolezel, David},
   article_location = {San Francisco},
   article_number = {9},
   doi = {http://dx.doi.org/10.1371/journal.pgen.1010924},
   keywords = {Circadian rhythms; RNA interference; Larvae; Insects; Drosophila melanogaster; Hormones; Biological locomotion; Exon mapping},
   language = {eng},
   issn = {1553-7404},
   journal = {PLoS Genetics},
   title = {Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock},
   url = {https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010924},
   volume = {19},
   year = {2023}
}

TY  - JOUR
ID  - 2362038
AU  - Smykal, Vlastimil - Chodakova, Lenka - Hejnikova, Marketa - Briediková, Kristína - Wu, Bulah Chia-Hsiang - Vaneckova, Hana - Chen, Ping - Janovska, Anna - Kyjakova, Pavlina - Vácha, Martin - Dolezel, David
PY  - 2023
TI  - Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock
JF  - PLoS Genetics
VL  - 19
IS  - 9
SP  - 1-25
EP  - 1-25
PB  - Public Library Science
SN  - 15537404
KW  - Circadian rhythms
KW  - RNA interference
KW  - Larvae
KW  - Insects
KW  - Drosophila melanogaster
KW  - Hormones
KW  - Biological locomotion
KW  - Exon mapping
UR  - https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010924
N2  - TAIMAN (TAI), the only insect ortholog of mammalian Steroid Receptor Coactivators (SRCs), is a critical modulator of ecdysone and juvenile hormone (JH) signaling pathways, which govern insect development and reproduction. The modulatory effect is mediated by JH-dependent TAI’s heterodimerization with JH receptor Methoprene-tolerant and association with the Ecdysone Receptor complex. Insect hormones regulate insect physiology and development in concert with abiotic cues, such as photo- and thermoperiod. Here we tested the effects of JH and ecdysone signaling on the circadian clock by a combination of microsurgical operations, application of hormones and hormone mimics, and gene knockdowns in the linden bug Pyrrhocoris apterus males. Silencing taiman by each of three non-overlapping double-strand RNA fragments dramatically slowed the free-running period (FRP) to 27–29 hours, contrasting to 24 hours in controls. To further corroborate TAIMAN’s clock modulatory function in the insect circadian clock, we performed taiman knockdown in the cockroach Blattella germanica. Although Blattella and Pyrrhocoris lineages separated ~380 mya, B. germanica taiman silencing slowed the FRP by more than 2 hours, suggesting a conserved TAI clock function in (at least) some insect groups. Interestingly, the pace of the linden bug circadian clock was neither changed by blocking JH and ecdysone synthesis, by application of the hormones or their mimics nor by the knockdown of corresponding hormone receptors. Our results promote TAI as a new circadian clock modulator, a role described for the first time in insects. We speculate that TAI participation in the clock is congruent with the mammalian SRC-2 role in orchestrating metabolism and circadian rhythms, and that TAI/SRCs might be conserved components of the circadian clock in animals.
ER  -

SMYKAL, Vlastimil, Lenka CHODAKOVA, Marketa HEJNIKOVA, Kristína BRIEDIKOVÁ, Bulah Chia-Hsiang WU, Hana VANECKOVA, Ping CHEN, Anna JANOVSKA, Pavlina KYJAKOVA, Martin VÁCHA a David DOLEZEL. Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock. \textit{PLoS Genetics}. San Francisco: Public Library Science, 2023, roč.~19, č.~9, s.~1-25. ISSN~1553-7404. Dostupné z: https://dx.doi.org/10.1371/journal.pgen.1010924.

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