Comparative Analysis of The Phytochemicals, Cytotoxicity and
Anti-Inflammatory Activities of Four Annonaceous (Uvaria) Plant
Species

a 2023

Comparative Analysis of The Phytochemicals, Cytotoxicity and Anti-Inflammatory Activities of Four Annonaceous (Uvaria) Plant Species

ADEKOYA, Ademola, Jakub TREML a Karel ŠMEJKAL

Základní údaje

Originální název

Comparative Analysis of The Phytochemicals, Cytotoxicity and Anti-Inflammatory Activities of Four Annonaceous (Uvaria) Plant Species

Autoři

ADEKOYA, Ademola (566 Nigérie, garant, domácí), Jakub TREML (203 Česká republika, domácí) a Karel ŠMEJKAL (203 Česká republika, domácí)

Vydání

2023

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Turecko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14160/23:00133101

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Annonaceae; anti-inflammatory; chromatography; NF-kB; Uvaria spp.; THP1-Xblue cell lin

Štítky

rivok, ÚMF, ÚPL

Příznaky

Mezinárodní význam

Změněno: 19. 1. 2024 14:05, JUDr. Sabina Krejčiříková

Anotace

V originále

Plants of the genus Uvaria belong to the Annonaceae family. This genus is represented by climbing shrubs distributed mainly in the tropics, particularly in Asia, Africa, and Australia. Their ethnobotanical uses include the treatment of tumors and fever. This study presents a comparative analysis of phytochemical profiles, cytotoxicity, and anti-inflammatory activities of four distinct Uvaria species: U. grandiflora, U. siamensis, U. rufa, and U. clementis. Our investigation focuses on elucidating their potential medicinal attributes and aiding in the selection of candidates with promise for drug development. Phytochemical characterization employed qualitative and chromatographic analyses. Remarkable variances in phytochemical compositions emerged, reflecting the unique chemical identities of the four Uvaria species. In vitro cell cultures were used to test the effects of Uvaria extracts on cell growth and survival as part of the cytotoxicity test. Outcomes displayed species-specific cytotoxic effects on the THP-1 human leukemia cell line, pointing towards possible bioactive compounds for anti-tumor and anti-cancer investigations. Antiinflammatory in vitro assays were employed to gauge the inhibition of a critical pro-inflammatory marker, NFkB, utilizing THP1-X blue cells. Notable anti-inflammatory actions were evident, as the extracts mitigated the release of inflammatory mediators, possibly linked to their phytochemical content. In conclusion, this comparative analysis underscores the distinctive phytochemical diversity within U. grandiflora, U. siamensis, U. rufa, and U. clementis. The observed cytotoxicity and potent anti-inflammatory effects highlight their therapeutic prospects. Future research should focus on isolating and identifying specific bioactive components responsible for these effects, shedding light on underlying mechanisms. These findings advocate for the exploration of Annonaceae plant resources, emphasizing their potential in pharmaceutical and medicinal applications.

Návaznosti

MUNI/A/1191/2022, interní kód MU

Název: Rostliny čeledi Annonaceae jako zdroje bioaktivních látek

Investor: Masarykova univerzita, Rostliny čeledi Annonaceae jako zdroje bioaktivních látek

Citovat

ADEKOYA, Ademola, Jakub TREML a Karel ŠMEJKAL. Comparative Analysis of The Phytochemicals, Cytotoxicity and Anti-Inflammatory Activities of Four Annonaceous (Uvaria) Plant Species. 2023.

@proceedings{2362961,
   author = {Adekoya, Ademola and Treml, Jakub and Šmejkal, Karel},
   keywords = {Annonaceae; anti-inflammatory; chromatography; NF-kB; Uvaria spp.; THP1-Xblue cell lin},
   language = {eng},
   title = {Comparative Analysis of The Phytochemicals, Cytotoxicity and Anti-Inflammatory Activities of Four Annonaceous (Uvaria) Plant Species},
   url = {https://www.pse2023.org/},
   year = {2023}
}

TY  - CONF
ID  - 2362961
AU  - Adekoya, Ademola - Treml, Jakub - Šmejkal, Karel
PY  - 2023
TI  - Comparative Analysis of The Phytochemicals, Cytotoxicity and Anti-Inflammatory Activities of Four Annonaceous (Uvaria) Plant Species
KW  - Annonaceae
KW  - anti-inflammatory
KW  - chromatography
KW  - NF-kB
KW  - Uvaria spp.
KW  - THP1-Xblue cell lin
UR  - https://www.pse2023.org/
N2  - Plants of the genus Uvaria belong to the Annonaceae family. This genus is represented by climbing shrubs distributed mainly in the tropics, particularly in Asia, Africa, and Australia. Their ethnobotanical uses include the treatment of tumors and fever. This study presents a comparative analysis of phytochemical profiles, cytotoxicity, and anti-inflammatory activities of four distinct Uvaria species: U. grandiflora, U. siamensis, U. rufa, and U. clementis. Our investigation focuses on elucidating their potential medicinal attributes and aiding in the selection of candidates with promise for drug development. Phytochemical characterization employed qualitative and chromatographic analyses. Remarkable variances in phytochemical compositions emerged, reflecting the unique chemical identities of the four Uvaria species. In vitro cell cultures were used to test the effects of Uvaria extracts on cell growth and survival as part of the cytotoxicity test. Outcomes displayed species-specific cytotoxic effects on the THP-1 human leukemia cell line, pointing towards possible bioactive compounds for anti-tumor and anti-cancer investigations. Antiinflammatory in vitro assays were employed to gauge the inhibition of a critical pro-inflammatory marker, NFkB, utilizing THP1-X blue cells. Notable anti-inflammatory actions were evident, as the extracts mitigated the release of inflammatory mediators, possibly linked to their phytochemical content. In conclusion, this comparative analysis underscores the distinctive phytochemical diversity within U. grandiflora, U. siamensis, U. rufa, and U. clementis. The observed cytotoxicity and potent anti-inflammatory effects highlight their therapeutic prospects. Future research should focus on isolating and identifying specific bioactive components responsible for these effects, shedding light on underlying mechanisms. These findings advocate for the exploration of Annonaceae plant resources, emphasizing their potential in pharmaceutical and medicinal applications.
ER  -

ADEKOYA, Ademola, Jakub TREML a Karel ŠMEJKAL. \textit{Comparative Analysis of The Phytochemicals, Cytotoxicity and Anti-Inflammatory Activities of Four Annonaceous (Uvaria) Plant Species}. 2023.

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