HURNÍK, Pavel, Jana REŽNAROVÁ, Zuzana CHYRA, Oldřich MOTYKA, Barbora MOLDOVAN PUTNOVÁ, Zuzana ČERMÁKOVÁ, Tomáš BLAŽEK, Martin FOMÁNEK, Daria GAYKALOVA, Marcela BUCHTOVÁ, Tereza ŠEVČÍKOVÁ a Jan ŠTEMBÍREK. Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins. Frontiers in Oncology. LAUSANNE: Frontiers Media SA, 2023, roč. 13, December 2023, s. 1-19. ISSN 2234-943X. Dostupné z: https://dx.doi.org/10.3389/fonc.2023.1287650. |
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@article{2364616, author = {Hurník, Pavel and Režnarová, Jana and Chyra, Zuzana and Motyka, Oldřich and Moldovan Putnová, Barbora and Čermáková, Zuzana and Blažek, Tomáš and Fománek, Martin and Gaykalova, Daria and Buchtová, Marcela and Ševčíková, Tereza and Štembírek, Jan}, article_location = {LAUSANNE}, article_number = {December 2023}, doi = {http://dx.doi.org/10.3389/fonc.2023.1287650}, keywords = {orofacial oncology; squamous cell carcinoma; mutation; surgical margins; biomarkers}, language = {eng}, issn = {2234-943X}, journal = {Frontiers in Oncology}, title = {Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins}, url = {https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1287650/full}, volume = {13}, year = {2023} }
TY - JOUR ID - 2364616 AU - Hurník, Pavel - Režnarová, Jana - Chyra, Zuzana - Motyka, Oldřich - Moldovan Putnová, Barbora - Čermáková, Zuzana - Blažek, Tomáš - Fománek, Martin - Gaykalova, Daria - Buchtová, Marcela - Ševčíková, Tereza - Štembírek, Jan PY - 2023 TI - Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins JF - Frontiers in Oncology VL - 13 IS - December 2023 SP - 1-19 EP - 1-19 PB - Frontiers Media SA SN - 2234943X KW - orofacial oncology KW - squamous cell carcinoma KW - mutation KW - surgical margins KW - biomarkers UR - https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1287650/full N2 - Objective Oral squamous cell carcinoma (OSCC) originates from the mucosal lining of the oral cavity. Almost half of newly diagnosed cases are classified as advanced stage IV disease, which makes resection difficult. In this study, we investigated the pathological features and mutation profiles of tumor margins in OSCC. Methods We performed hierarchical clustering of principal components to identify distinct patterns of tumor growth and their association with patient prognosis. We also used next-generation sequencing to analyze somatic mutations in tumor and marginal tissue samples. Results Our analyses uncovered that the grade of worst pattern of invasion (WPOI) is strongly associated with depth of invasion and patient survival in multivariable analysis. Mutations were primarily detected in the DNA isolated from tumors, but several mutations were also identified in marginal tissue. In total, we uncovered 29 mutated genes, mainly tumor suppressor genes involved in DNA repair including BRCA genes; however none of these mutations significantly correlated with a higher chance of relapse in our medium-size cohort. Some resection margins that appeared histologically normal harbored tumorigenic mutations in TP53 and CDKN2A genes. Conclusion Even histologically normal margins may contain molecular alterations that are not detectable by conventional histopathological methods, but NCCN classification system still outperforms other methods in the prediction of the probability of disease relapse. ER -
HURNÍK, Pavel, Jana REŽNAROVÁ, Zuzana CHYRA, Oldřich MOTYKA, Barbora MOLDOVAN PUTNOVÁ, Zuzana ČERMÁKOVÁ, Tomáš BLAŽEK, Martin FOMÁNEK, Daria GAYKALOVA, Marcela BUCHTOVÁ, Tereza ŠEVČÍKOVÁ a Jan ŠTEMBÍREK. Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins. \textit{Frontiers in Oncology}. LAUSANNE: Frontiers Media SA, 2023, roč.~13, December 2023, s.~1-19. ISSN~2234-943X. Dostupné z: https://dx.doi.org/10.3389/fonc.2023.1287650.
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