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@article{2364939, author = {Contini, Thomas Angelo Adrien and Beranger, Remi and Multigner, Luc and Klánová, Jana and Price, Elliott James and David, Arthur}, article_location = {WASHINGTON}, article_number = {41}, doi = {http://dx.doi.org/10.1021/acs.est.3c04845}, keywords = {placenta; prenatal; xenobiotics; high-resolutionmass spectrometry; chemical exposomics; metabolomics; suspect screening; nontargeted}, language = {eng}, issn = {0013-936X}, journal = {ENVIRONMENTAL SCIENCE & TECHNOLOGY}, title = {A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome}, url = {https://pubs.acs.org/doi/10.1021/acs.est.3c04845}, volume = {57}, year = {2023} }
TY - JOUR ID - 2364939 AU - Contini, Thomas Angelo Adrien - Beranger, Remi - Multigner, Luc - Klánová, Jana - Price, Elliott James - David, Arthur PY - 2023 TI - A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome JF - ENVIRONMENTAL SCIENCE & TECHNOLOGY VL - 57 IS - 41 SP - 15301-15313 EP - 15301-15313 PB - AMER CHEMICAL SOC SN - 0013936X KW - placenta KW - prenatal KW - xenobiotics KW - high-resolutionmass spectrometry KW - chemical exposomics KW - metabolomics KW - suspect screening KW - nontargeted UR - https://pubs.acs.org/doi/10.1021/acs.est.3c04845 N2 - Adverse effects associated with chemical exposures during pregnancy include several developmental and reproductive disorders. However, considering the tens of thousands of chemicals present on the market, the effects of chemical mixtures on the developing fetus is still likely underestimated. In this critical review, we discuss the potential to apply innovative biomonitoring methods using high-resolution mass spectrometry (HRMS) on placenta to improve the monitoring of chemical exposure during pregnancy. The physiology of the placenta and its relevance as a matrix for monitoring chemical exposures and their effects on fetal health is first outlined. We then identify several key parameters that require further investigations before placenta can be used for large-scale monitoring in a robust manner. Most critical is the need for standardization of placental sampling. Placenta is a highly heterogeneous organ, and knowledge of the intraplacenta variability of chemical composition is required to ensure unbiased and robust interindividual comparisons. Other important variables include the time of collection, the sex of the fetus, and mode of delivery. Finally, we discuss the first applications of HRMS methods on the placenta to decipher the chemical exposome and describe how the use of placenta can complement biofluids collected on the mother or the fetus. ER -
CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE a Arthur DAVID. A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome. \textit{ENVIRONMENTAL SCIENCE \&{}amp; TECHNOLOGY}. WASHINGTON: AMER CHEMICAL SOC, 2023, roč.~57, č.~41, s.~15301-15313. ISSN~0013-936X. Dostupné z: https://dx.doi.org/10.1021/acs.est.3c04845.
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