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@article{2364939,
author = {Contini, Thomas Angelo Adrien and Beranger, Remi and Multigner, Luc and Klánová, Jana and Price, Elliott James and David, Arthur},
article_location = {WASHINGTON},
article_number = {41},
doi = {http://dx.doi.org/10.1021/acs.est.3c04845},
keywords = {placenta; prenatal; xenobiotics; high-resolutionmass spectrometry; chemical exposomics; metabolomics; suspect screening; nontargeted},
language = {eng},
issn = {0013-936X},
journal = {ENVIRONMENTAL SCIENCE & TECHNOLOGY},
title = {A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome},
url = {https://pubs.acs.org/doi/10.1021/acs.est.3c04845},
volume = {57},
year = {2023}
}
TY - JOUR
ID - 2364939
AU - Contini, Thomas Angelo Adrien - Beranger, Remi - Multigner, Luc - Klánová, Jana - Price, Elliott James - David, Arthur
PY - 2023
TI - A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome
JF - ENVIRONMENTAL SCIENCE & TECHNOLOGY
VL - 57
IS - 41
SP - 15301-15313
EP - 15301-15313
PB - AMER CHEMICAL SOC
SN - 0013936X
KW - placenta
KW - prenatal
KW - xenobiotics
KW - high-resolutionmass spectrometry
KW - chemical exposomics
KW - metabolomics
KW - suspect screening
KW - nontargeted
UR - https://pubs.acs.org/doi/10.1021/acs.est.3c04845
N2 - Adverse effects associated with chemical exposures during pregnancy include several developmental and reproductive disorders. However, considering the tens of thousands of chemicals present on the market, the effects of chemical mixtures on the developing fetus is still likely underestimated. In this critical review, we discuss the potential to apply innovative biomonitoring methods using high-resolution mass spectrometry (HRMS) on placenta to improve the monitoring of chemical exposure during pregnancy. The physiology of the placenta and its relevance as a matrix for monitoring chemical exposures and their effects on fetal health is first outlined. We then identify several key parameters that require further investigations before placenta can be used for large-scale monitoring in a robust manner. Most critical is the need for standardization of placental sampling. Placenta is a highly heterogeneous organ, and knowledge of the intraplacenta variability of chemical composition is required to ensure unbiased and robust interindividual comparisons. Other important variables include the time of collection, the sex of the fetus, and mode of delivery. Finally, we discuss the first applications of HRMS methods on the placenta to decipher the chemical exposome and describe how the use of placenta can complement biofluids collected on the mother or the fetus.
ER -
CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE a Arthur DAVID. A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome. \textit{ENVIRONMENTAL SCIENCE \&{}amp; TECHNOLOGY}. WASHINGTON: AMER CHEMICAL SOC, 2023, roč.~57, č.~41, s.~15301-15313. ISSN~0013-936X. Dostupné z: https://dx.doi.org/10.1021/acs.est.3c04845.
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