Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns

BOEKEMA, Bouke K H L, Daniela CHRYSOSTOMOU, Guido CIPRANDI, Anouk ELGERSMA, Marcel VLIG, Andrea POKORNÁ, Linsey J F PETERS a Niels A J CREMERS. Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns. Burns. OXFORD: ELSEVIER, 2024, roč. 50, č. 3, s. 597-610. ISSN 0305-4179. Dostupné z: https://dx.doi.org/10.1016/j.burns.2023.10.009.

Základní údaje

• Originální název: Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns
• Autoři: BOEKEMA, Bouke K H L, Daniela CHRYSOSTOMOU (710 Jižní Afrika, domácí), Guido CIPRANDI, Anouk ELGERSMA, Marcel VLIG, Andrea POKORNÁ (203 Česká republika, domácí), Linsey J F PETERS a Niels A J CREMERS.
• Vydání: Burns, OXFORD, ELSEVIER, 2024, 0305-4179.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30216 Dermatology and venereal diseases
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Impakt faktor: Impact factor: 2.700 v roce 2022
• Organizační jednotka: Lékařská fakulta
• Doi: http://dx.doi.org/10.1016/j.burns.2023.10.009
• UT WoS: 001218241200001
• Klíčová slova anglicky: Medical-grade honey; Pseudomonas aeruginosa; Silver sulphadiazine; Silver nitrate; Infected burn wounds; Wound healing
• Štítky: 14110525, 14110611, rivok
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Burns are a major global healthcare concern, often complicated by the presence of bacteria such as Pseudomonas aeruginosa in the wounds. Silver-based dressings are commonly used in the treatment of burns but can cause skin irritation and delay healing time. Medical-grade honey (MGH) provides an interesting alternative. This study investigated the antimicrobial effects and possible cytotoxicity of L-Mesitran Soft (MGH-gel) and its individual components, Medihoney (Manuka), Flammazine (silver sulphadiazine), and silver nitrate (AgNO3) in an ex vivo human burn wound model. Bacterial survival and wound healing parameters, including re-epithelialization and keratinocyte proliferation were assessed. L-Mesitran, Flammazine, and AgNO3 reduced P. aeruginosa numbers below detection levels. L-Mesitran Soft exhibited a significantly stronger antimicrobial effect compared to Medihoney. The individual components of L-Mesitran contributed significantly to its antibacterial efficacy, thus suggesting synergistic activities. Moreover, L-Mesitran, Flammazine, and AgNO3 slightly inhibited re-epithelialization while Medihoney treatment resulted in a complete lack of re-epithelialization and keratinocyte proliferation. Furthermore, clinical cases illustrated the effectiveness of MGH therapy in infected burns. Overall, L-Mesitran Soft had similar effects as silver-based products on bacterial load and epidermal regeneration, but outperformed Medihoney. Therefore, supplemented MGH could be used as an effective alternative to silver-based dressings for P. aeruginosa-infected burns.