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@article{2365520,
author = {Koutarapu, Srinivas and Ge, Junyue and Jha, Durga and Blennow, Kaj and Zetterberg, Henrik and Lashley, Tammaryn and Michno, Wojciech and Hanrieder, Jorg},
article_number = {5},
doi = {http://dx.doi.org/10.1089/brain.2022.0047},
keywords = {Alzheimer's disease; beta-amyloid; cored plaques; dystrophic neuritis; matrix-assisted laser; desorption ionization mass spectrometry imaging; neuritic plaques},
language = {eng},
issn = {2158-0014},
journal = {Brain Connectivity},
title = {Correlative Chemical Imaging Identifies Amyloid Peptide Signatures of Neuritic Plaques and Dystrophy in Human Sporadic Alzheimer's Disease},
url = {https://www.liebertpub.com/doi/10.1089/brain.2022.0047},
volume = {13},
year = {2023}
}
TY - JOUR
ID - 2365520
AU - Koutarapu, Srinivas - Ge, Junyue - Jha, Durga - Blennow, Kaj - Zetterberg, Henrik - Lashley, Tammaryn - Michno, Wojciech - Hanrieder, Jorg
PY - 2023
TI - Correlative Chemical Imaging Identifies Amyloid Peptide Signatures of Neuritic Plaques and Dystrophy in Human Sporadic Alzheimer's Disease
JF - Brain Connectivity
VL - 13
IS - 5
SP - 297-306
EP - 297-306
PB - Mary Ann Liebert Inc.
SN - 21580014
KW - Alzheimer's disease
KW - beta-amyloid
KW - cored plaques
KW - dystrophic neuritis
KW - matrix-assisted laser
KW - desorption ionization mass spectrometry imaging
KW - neuritic plaques
UR - https://www.liebertpub.com/doi/10.1089/brain.2022.0047
N2 - Objective: Alzheimer's disease (AD) is the most common neurodegenerative disease. The predominantly sporadic form of AD is age-related, but the underlying pathogenic mechanisms remain not fully understood. Current efforts to combat the disease focus on the main pathological hallmarks, in particular beta-amyloid (A beta) plaque pathology. According to the amyloid cascade hypothesis, A beta is the critical early initiator of AD pathogenesis. Plaque pathology is very heterogeneous, where a subset of plaques, neuritic plaques (NPs), are considered most neurotoxic rendering their in-depth characterization essential to understand A beta pathogenicity.Methods: To delineate the chemical traits specific to NP types, we investigated senile A beta pathology in the postmortem, human sporadic AD brain using advanced correlative biochemical imaging based on immunofluorescence (IF) microscopy and mass spectrometry imaging (MSI).Results: Immunostaining-guided MSI identified distinct A beta signatures of NPs characterized by increased A beta 1-42(ox) and A beta 2-42. Moreover, correlation with a marker of dystrophy (reticulon 3 [RTN3]) identified key A beta species that both delineate NPs and display association with neuritic dystrophy.Conclusion: Together, these correlative imaging data shed light on the complex biochemical architecture of NPs and associated dystrophic neurites. These in turn are obvious targets for disease-modifying treatment strategies, as well as novel biomarkers of A beta pathogenicity.
ER -
KOUTARAPU, Srinivas, Junyue GE, Durga JHA, Kaj BLENNOW, Henrik ZETTERBERG, Tammaryn LASHLEY, Wojciech MICHNO a Jorg HANRIEDER. Correlative Chemical Imaging Identifies Amyloid Peptide Signatures of Neuritic Plaques and Dystrophy in Human Sporadic Alzheimer's Disease. \textit{Brain Connectivity}. Mary Ann Liebert Inc., 2023, roč.~13, č.~5, s.~297-306. ISSN~2158-0014. Dostupné z: https://dx.doi.org/10.1089/brain.2022.0047.
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