Neural correlates of social exclusion and overinclusion in
patients with borderline personality disorder: an fMRI study

J 2023

Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study

LÁTALOVÁ, Adéla, Monika RADIMECKÁ, Martin LAMOŠ, Martin JÁNI, Alena DAMBORSKÁ et. al.

Basic information

Original name

Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study

Authors

LÁTALOVÁ, Adéla (203 Czech Republic, belonging to the institution), Monika RADIMECKÁ (203 Czech Republic, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), Martin JÁNI (703 Slovakia, belonging to the institution), Alena DAMBORSKÁ (203 Czech Republic, belonging to the institution), Pavel THEINER (203 Czech Republic, belonging to the institution), Eliška BARTEČKOVÁ (203 Czech Republic, belonging to the institution), Patrik BARTYS (203 Czech Republic, belonging to the institution), Helena VLČKOVÁ (203 Czech Republic, belonging to the institution), Katarína ŠKOLIAKOVÁ (703 Slovakia, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution) and Pavla LINHARTOVÁ (203 Czech Republic, belonging to the institution)

Edition

BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION, LONDON, BMC, 2023, 2051-6673

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30215 Psychiatry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.100 in 2022

RIV identification code

RIV/00216224:14110/23:00133227

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s40479-023-00240-1

UT WoS

001111419800001

Keywords in English

Borderline personality disorder; Rejection sensitivity; Social exclusion; Social overinclusion; Cyberball paradigm; fMRI

Abstract

V originále

BackgroundInterpersonal difficulties of patients with borderline personality disorder (BPD) are closely related to rejection sensitivity. The aim of the present study was to gain further insight into the experience and cerebral processing of social interactions in patients with BPD by using fMRI during experimentally induced experiences of social exclusion, inclusion, and overinclusion.MethodsThe study involved 30 participants diagnosed with BPD (29 female and 1 male; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 female and 1 male; age: M = 24.66, SD = 5.28) with no current or lifetime psychiatric diagnoses. In the fMRI session, all participants were asked to complete a Cyberball task that consisted of an alternating sequence of inclusion, exclusion, and overinclusion conditions.ResultsCompared to healthy controls, participants with BPD reported higher levels of inner tension and more unpleasant emotions across all experimental conditions. At the neural level, the participants with BPD showed lower recruitment of the left hippocampus in response to social exclusion (relative to the inclusion condition) than the healthy controls did. Lower recruitment of the left hippocampus in this contrast was associated with childhood maltreatment in patients with BPD. However, this difference was no longer significant when we added the covariate of hippocampal volume to the analysis. During social overinclusion (relative to the inclusion condition), we observed no significant differences in a group comparison of neural activation.ConclusionsThe results of our study suggest that patients with BPD experience more discomfort than do healthy controls during social interactions. Compared to healthy participants, patients with BPD reported more inner tension and unpleasant emotions, irrespective of the extent to which others included them in social interactions. At a neural level, the participants with BPD showed a lower recruitment of the left hippocampus in response to social exclusion than the healthy controls did. The reduced activation of this neural structure could be related to a history of childhood maltreatment and smaller hippocampal volume in patients with BPD.

Links

NU20-04-00410, research and development project

Name: Neurální mechanismy dialektické behaviorální terapie u pacientů s hraniční poruchou osobnosti (Acronym: NU20-04-00410)

Investor: Ministry of Health of the CR, Subprogram 1 - standard

90250, large research infrastructures

Name: Czech-BioImaging III

Citovat

LÁTALOVÁ, Adéla, Monika RADIMECKÁ, Martin LAMOŠ, Martin JÁNI, Alena DAMBORSKÁ, Pavel THEINER, Eliška BARTEČKOVÁ, Patrik BARTYS, Helena VLČKOVÁ, Katarína ŠKOLIAKOVÁ, Tomáš KAŠPÁREK and Pavla LINHARTOVÁ. Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study. BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION. LONDON: BMC, 2023, vol. 10, No 1, p. 1-14. ISSN 2051-6673. Available from: https://dx.doi.org/10.1186/s40479-023-00240-1.

@article{2365644,
   author = {Látalová, Adéla and Radimecká, Monika and Lamoš, Martin and Jáni, Martin and Damborská, Alena and Theiner, Pavel and Bartečková, Eliška and Bartys, Patrik and Vlčková, Helena and Školiaková, Katarína and Kašpárek, Tomáš and Linhartová, Pavla},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s40479-023-00240-1},
   keywords = {Borderline personality disorder; Rejection sensitivity; Social exclusion; Social overinclusion; Cyberball paradigm; fMRI},
   language = {eng},
   issn = {2051-6673},
   journal = {BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION},
   title = {Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study},
   url = {https://bpded.biomedcentral.com/articles/10.1186/s40479-023-00240-1},
   volume = {10},
   year = {2023}
}

TY  - JOUR
ID  - 2365644
AU  - Látalová, Adéla - Radimecká, Monika - Lamoš, Martin - Jáni, Martin - Damborská, Alena - Theiner, Pavel - Bartečková, Eliška - Bartys, Patrik - Vlčková, Helena - Školiaková, Katarína - Kašpárek, Tomáš - Linhartová, Pavla
PY  - 2023
TI  - Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study
JF  - BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
VL  - 10
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - BMC
SN  - 20516673
KW  - Borderline personality disorder
KW  - Rejection sensitivity
KW  - Social exclusion
KW  - Social overinclusion
KW  - Cyberball paradigm
KW  - fMRI
UR  - https://bpded.biomedcentral.com/articles/10.1186/s40479-023-00240-1
N2  - BackgroundInterpersonal difficulties of patients with borderline personality disorder (BPD) are closely related to rejection sensitivity. The aim of the present study was to gain further insight into the experience and cerebral processing of social interactions in patients with BPD by using fMRI during experimentally induced experiences of social exclusion, inclusion, and overinclusion.MethodsThe study involved 30 participants diagnosed with BPD (29 female and 1 male; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 female and 1 male; age: M = 24.66, SD = 5.28) with no current or lifetime psychiatric diagnoses. In the fMRI session, all participants were asked to complete a Cyberball task that consisted of an alternating sequence of inclusion, exclusion, and overinclusion conditions.ResultsCompared to healthy controls, participants with BPD reported higher levels of inner tension and more unpleasant emotions across all experimental conditions. At the neural level, the participants with BPD showed lower recruitment of the left hippocampus in response to social exclusion (relative to the inclusion condition) than the healthy controls did. Lower recruitment of the left hippocampus in this contrast was associated with childhood maltreatment in patients with BPD. However, this difference was no longer significant when we added the covariate of hippocampal volume to the analysis. During social overinclusion (relative to the inclusion condition), we observed no significant differences in a group comparison of neural activation.ConclusionsThe results of our study suggest that patients with BPD experience more discomfort than do healthy controls during social interactions. Compared to healthy participants, patients with BPD reported more inner tension and unpleasant emotions, irrespective of the extent to which others included them in social interactions. At a neural level, the participants with BPD showed a lower recruitment of the left hippocampus in response to social exclusion than the healthy controls did. The reduced activation of this neural structure could be related to a history of childhood maltreatment and smaller hippocampal volume in patients with BPD.
ER  -

LÁTALOVÁ, Adéla, Monika RADIMECKÁ, Martin LAMOŠ, Martin JÁNI, Alena DAMBORSKÁ, Pavel THEINER, Eliška BARTEČKOVÁ, Patrik BARTYS, Helena VLČKOVÁ, Katarína ŠKOLIAKOVÁ, Tomáš KAŠPÁREK and Pavla LINHARTOVÁ. Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study. \textit{BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION}. LONDON: BMC, 2023, vol.~10, No~1, p.~1-14. ISSN~2051-6673. Available from: https://dx.doi.org/10.1186/s40479-023-00240-1.

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