| URBANOVA, Martina, Jan MACKŮ, Kateřina KUBOVÁ, Jakub VYSLOUŽIL, Jan MUSELÍK, Miroslav SLOUF, Ivana SEDENKOVA, Olga KOCKOVA, Larisa JANISOVA, Josef MASEK, Eliska MASKOVA, Adam NOVOBILSKY, Martina PARENICOVA, Rafal KONEFAL, Jiri CZERNEK, David VETCHÝ, Miroslava PAVELKOVÁ a Jiri BRUS. Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+and Zn2+ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics. Food Hydrocolloids. Oxford: Elsevier Science, 2024, roč. 150, May 2024, s. 1-16. ISSN 0268-005X. Dostupné z: https://dx.doi.org/10.1016/j.foodhyd.2023.109693. |
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@article{2365871,
author = {Urbanova, Martina and Macků, Jan and Kubová, Kateřina and Vysloužil, Jakub and Muselík, Jan and Slouf, Miroslav and Sedenkova, Ivana and Kockova, Olga and Janisova, Larisa and Masek, Josef and Maskova, Eliska and Novobilsky, Adam and Parenicova, Martina and Konefal, Rafal and Czernek, Jiri and Vetchý, David and Pavelková, Miroslava and Brus, Jiri},
article_location = {Oxford},
article_number = {May 2024},
doi = {http://dx.doi.org/10.1016/j.foodhyd.2023.109693},
keywords = {Alginate-pectin gels; Dual crosslinking; Structure; Self-emulsifying systems; Lipophilic phytotherapeutics; Solid-state NMR},
language = {eng},
issn = {0268-005X},
journal = {Food Hydrocolloids},
title = {Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+and Zn2+ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0268005X23012390?via%3Dihub},
volume = {150},
year = {2024}
}
TY - JOUR
ID - 2365871
AU - Urbanova, Martina - Macků, Jan - Kubová, Kateřina - Vysloužil, Jakub - Muselík, Jan - Slouf, Miroslav - Sedenkova, Ivana - Kockova, Olga - Janisova, Larisa - Masek, Josef - Maskova, Eliska - Novobilsky, Adam - Parenicova, Martina - Konefal, Rafal - Czernek, Jiri - Vetchý, David - Pavelková, Miroslava - Brus, Jiri
PY - 2024
TI - Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+and Zn2+ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics
JF - Food Hydrocolloids
VL - 150
IS - May 2024
SP - 1-16
EP - 1-16
PB - Elsevier Science
SN - 0268005X
KW - Alginate-pectin gels
KW - Dual crosslinking
KW - Structure
KW - Self-emulsifying systems
KW - Lipophilic phytotherapeutics
KW - Solid-state NMR
UR - https://www.sciencedirect.com/science/article/abs/pii/S0268005X23012390?via%3Dihub
N2 - Alginate gels are outstanding biomaterials widely applicable in food and pharmaceutical industries. This contribution provides comprehensive insight into the design of advanced hybrid alginate/pectin co -networks double crosslinked by Ca2+/Zn2+ ions encapsulating self -emulsifying systems (SES). The tunable mucoadhesive properties, structural stability, integrity, dissolution profiles, and enhanced in -vivo bioavailability make the synthesized hybrid systems ideal vehicles for the delivery of lipophilic phytotherapeutics, allowing the long-term site -specific treatment of intestinal inflammation. This work also provides a thorough understanding of the structure -property relationships of alginate -pectin gels at the atomic resolution level. It was found out that SES molecules form well -distributed, phase -separated microparticles that interact with the polysaccharide matrix through a well-defined interface. The hybrid alginate -pectin gel is highly cross -linked, with both types of polysaccharides participating in the network formation. The observed surface interactions of SES droplets increase the intrinsic mobility of the network. The plasticizing effect can be regulated by the amount of pectin macromolecules, whose interaction with alginate chains enables a strengthening of the polysaccharide network. Overall, the domain -like architecture of hybrid alginate -pectin gels synthesized by external ionic gelation is revealed; the key structural motifs responsible for their properties are discovered; and the pathways allowing their regulation are identified. Biological in -vivo tests then confirmed positive effects of the synthesized systems in living organisms. The strategy presented thus offers a new perspective for the rational design of alginate -based materials for the microencapsulation of bioactive compounds for advanced orally administered delivery systems or controlled -release decontaminators applicable in the food and nutraceutical processing industries.
ER -
URBANOVA, Martina, Jan MACKŮ, Kateřina KUBOVÁ, Jakub VYSLOUŽIL, Jan MUSELÍK, Miroslav SLOUF, Ivana SEDENKOVA, Olga KOCKOVA, Larisa JANISOVA, Josef MASEK, Eliska MASKOVA, Adam NOVOBILSKY, Martina PARENICOVA, Rafal KONEFAL, Jiri CZERNEK, David VETCHÝ, Miroslava PAVELKOVÁ a Jiri BRUS. Structure, dynamics, and functional properties of hybrid alginate-pectin gels dually crosslinked by Ca2+and Zn2+ions designed as a delivery device for self-emulsifying systems for lipophilic phytotherapeutics. \textit{Food Hydrocolloids}. Oxford: Elsevier Science, 2024, roč.~150, May 2024, s.~1-16. ISSN~0268-005X. Dostupné z: https://dx.doi.org/10.1016/j.foodhyd.2023.109693.
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