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@proceedings{2365917,
author = {Onuščáková, Magdaléna and Pížová, Hana and Kauerová, Tereza and Kollár, Peter and Bobáľ, Pavel},
booktitle = {51st Conference Synthesis and Analysis of Drugs.},
keywords = {HDAC inhibitors; Vorinostat; Hydroxamic acid},
language = {eng},
title = {Synthesis and evaluation biological activity of newly designed hydroxamates as potential HDAC inhibitors},
url = {https://sal2023.fpharm.uniba.sk/wp-content/uploads/2023/09/booklet_web.pdf},
year = {2023}
}
TY - CONF
ID - 2365917
AU - Onuščáková, Magdaléna - Pížová, Hana - Kauerová, Tereza - Kollár, Peter - Bobáľ, Pavel
PY - 2023
TI - Synthesis and evaluation biological activity of newly designed hydroxamates as potential HDAC inhibitors
KW - HDAC inhibitors
KW - Vorinostat
KW - Hydroxamic acid
UR - https://sal2023.fpharm.uniba.sk/wp-content/uploads/2023/09/booklet_web.pdf
N2 - Histone deacetylase inhibitors (HDACi) represent a relatively new generation of drugs with the ability to affect the expression of specific genes, which can repair controlled proliferation or damage apoptotic processes in tumor cells. HDAC inhibitors have considerable anticancer activity forming a complex with the Zn2+ ion in the catalytic pocket of enzymes.2
ER -
ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Peter KOLLÁR a Pavel BOBÁĽ. Synthesis and evaluation biological activity of newly designed hydroxamates as potential HDAC inhibitors. In \textit{51st Conference Synthesis and Analysis of Drugs.}. 2023.
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