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@proceedings{2365921,
author = {Onuščáková, Magdaléna and Pížová, Hana and Kauerová, Tereza and Kollár, Peter and Bobáľ, Pavel},
booktitle = {57th Conference: Advances in Organic, Bioorganic and Pharmaceutical Chemistry – Liblice.},
keywords = {HDAC inhibitors; Hydroxamic acids; Antineoplastic activity},
language = {eng},
title = {Synthesis and evaluation of biological activity of newly designed hydroxamates as potential HDAC inhibitors},
year = {2023}
}
TY - CONF
ID - 2365921
AU - Onuščáková, Magdaléna - Pížová, Hana - Kauerová, Tereza - Kollár, Peter - Bobáľ, Pavel
PY - 2023
TI - Synthesis and evaluation of biological activity of newly designed hydroxamates as potential HDAC inhibitors
KW - HDAC inhibitors
KW - Hydroxamic acids
KW - Antineoplastic activity
N2 - Histone deacetylases (HDACs) are metalloenzymes involved in the regulation of fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders.1 Histone deacetylase inhibitors (HDACi) represent a relatively new generation of drugs with the ability to affect the expression of specific genes, which can repair controlled proliferation or damage apoptotic processes in tumor cells
ER -
ONUŠČÁKOVÁ, Magdaléna, Hana PÍŽOVÁ, Tereza KAUEROVÁ, Peter KOLLÁR a Pavel BOBÁĽ. Synthesis and evaluation of biological activity of newly designed hydroxamates as potential HDAC inhibitors. In \textit{57th Conference: Advances in Organic, Bioorganic and Pharmaceutical Chemistry – Liblice.}. 2023.
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