Prognostic significance of early acute kidney injury in
COVID-19 patients requiring mechanical ventilation: a
single-center retrospective analysis

J 2023

Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis

ŠITINA, Michal, Vladimír ŠRÁMEK, Martin HELÁN a Pavel SUK

Základní údaje

Originální název

Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis

Autoři

ŠITINA, Michal (203 Česká republika, garant, domácí), Vladimír ŠRÁMEK (203 Česká republika, domácí), Martin HELÁN (203 Česká republika, domácí) a Pavel SUK (203 Česká republika, domácí)

Vydání

RENAL FAILURE, OXON, TAYLOR & FRANCIS LTD, 2023, 0886-022X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30217 Urology and nephrology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000 v roce 2022

Kód RIV

RIV/00216224:14110/23:00133300

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1080/0886022X.2023.2205954

UT WoS

000979829600001

Klíčová slova anglicky

COVID-19; acute kidney injury; renal replacement therapy; early kidney dysfunction

Štítky

14110122, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 1. 2024 14:52, Mgr. Tereza Miškechová

Anotace

V originále

Acute kidney injury (AKI) is associated with impaired outcomes in critically ill COVID-19 patients. However, the prognostic significance of early AKI is poorly described. We aimed to determine whether AKI on admission to the intensive care unit (ICU) and its development within the first 48 h predict the need for renal replacement therapy (RRT) and increased mortality. An analysis of 372 patients with COVID-19 pneumonia requiring mechanical ventilation without advanced chronic kidney disease from 2020 to 2021 was performed. The AKI stages on ICU admission and Day 2 were determined using adapted KDIGO criteria. The early development of renal function was assessed by the change in AKI score and the Day-2/Day-0 creatinine ratio. Data were compared between three consecutive COVID-19 waves and with data before the pandemic. Both ICU and 90-day mortality (79% and 93% vs. 35% and 44%) and the need for RRT increased markedly with advanced AKI stage on ICU admission. Similarly, an early increase in AKI stage and creatinine implied highly increased mortality. RRT was associated with very high ICU and 90-day mortality (72% and 85%), even surpassing that of patients on ECMO. No difference was found between consecutive COVID-19 waves, except for a lower mortality in the patients on RRT in the last omicron wave. Mortality and need for RRT were comparable in the COVID-19 and pre-COVID-19 patients, except that RRT did not increase ICU mortality in the pre-COVID-19 era. In conclusion, we confirmed the prognostic significance of both AKI on ICU admission and its early development in patients with severe COVID-19 pneumonia.

Citovat

ŠITINA, Michal, Vladimír ŠRÁMEK, Martin HELÁN a Pavel SUK. Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis. RENAL FAILURE. OXON: TAYLOR & FRANCIS LTD, 2023, roč. 45, č. 1, s. 1-8. ISSN 0886-022X. Dostupné z: https://dx.doi.org/10.1080/0886022X.2023.2205954.

@article{2367198,
   author = {Šitina, Michal and Šrámek, Vladimír and Helán, Martin and Suk, Pavel},
   article_location = {OXON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1080/0886022X.2023.2205954},
   keywords = {COVID-19; acute kidney injury; renal replacement therapy; early kidney dysfunction},
   language = {eng},
   issn = {0886-022X},
   journal = {RENAL FAILURE},
   title = {Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis},
   url = {https://www.tandfonline.com/doi/full/10.1080/0886022X.2023.2205954},
   volume = {45},
   year = {2023}
}

TY  - JOUR
ID  - 2367198
AU  - Šitina, Michal - Šrámek, Vladimír - Helán, Martin - Suk, Pavel
PY  - 2023
TI  - Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis
JF  - RENAL FAILURE
VL  - 45
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - TAYLOR & FRANCIS LTD
SN  - 0886022X
KW  - COVID-19
KW  - acute kidney injury
KW  - renal replacement therapy
KW  - early kidney dysfunction
UR  - https://www.tandfonline.com/doi/full/10.1080/0886022X.2023.2205954
N2  - Acute kidney injury (AKI) is associated with impaired outcomes in critically ill COVID-19 patients. However, the prognostic significance of early AKI is poorly described. We aimed to determine whether AKI on admission to the intensive care unit (ICU) and its development within the first 48 h predict the need for renal replacement therapy (RRT) and increased mortality. An analysis of 372 patients with COVID-19 pneumonia requiring mechanical ventilation without advanced chronic kidney disease from 2020 to 2021 was performed. The AKI stages on ICU admission and Day 2 were determined using adapted KDIGO criteria. The early development of renal function was assessed by the change in AKI score and the Day-2/Day-0 creatinine ratio. Data were compared between three consecutive COVID-19 waves and with data before the pandemic. Both ICU and 90-day mortality (79% and 93% vs. 35% and 44%) and the need for RRT increased markedly with advanced AKI stage on ICU admission. Similarly, an early increase in AKI stage and creatinine implied highly increased mortality. RRT was associated with very high ICU and 90-day mortality (72% and 85%), even surpassing that of patients on ECMO. No difference was found between consecutive COVID-19 waves, except for a lower mortality in the patients on RRT in the last omicron wave. Mortality and need for RRT were comparable in the COVID-19 and pre-COVID-19 patients, except that RRT did not increase ICU mortality in the pre-COVID-19 era. In conclusion, we confirmed the prognostic significance of both AKI on ICU admission and its early development in patients with severe COVID-19 pneumonia.
ER  -

ŠITINA, Michal, Vladimír ŠRÁMEK, Martin HELÁN a Pavel SUK. Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis. \textit{RENAL FAILURE}. OXON: TAYLOR \&{} FRANCIS LTD, 2023, roč.~45, č.~1, s.~1-8. ISSN~0886-022X. Dostupné z: https://dx.doi.org/10.1080/0886022X.2023.2205954.

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