In vitro biological activity of cobalt(II) complexes with
salicylaldimine ligands in microbial and cancer cells

J 2023

In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells

WILLIEM, Ereny S., Ahmed B. M. IBRAHIM, S. ABD ELKHALIK, Jaromír MAREK, S. M. ABBAS et. al.

Základní údaje

Originální název

In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells

Autoři

WILLIEM, Ereny S., Ahmed B. M. IBRAHIM (garant), S. ABD ELKHALIK, Jaromír MAREK (203 Česká republika, domácí) a S. M. ABBAS

Vydání

Future Medicinal Chemistry, Newlands Press Ltd, 2023, 1756-8919

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30107 Medicinal chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.200 v roce 2022

Kód RIV

RIV/00216224:14310/23:00133366

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.4155/fmc-2023-0190

UT WoS

001048093100001

Klíčová slova anglicky

anionic ligands; breast cells; Candida albicans; Schiff bases; Staphylococcus aureus; tetrahedral

Štítky

CF BIC, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 10. 2024 15:25, Ing. Martina Blahová

Anotace

V originále

Background: More studies using cobalt complexes as drugs are needed. Results: The drug action of two cobalt salicylaldimines was determined. The complexes and amphotericin B (20 mg/ml) inhibited Candida albicans at 9–15 and 21 mm. This concentration of both ligands inhibited Staphylococcus aureus at 10 mm and one ligand inhibited Escherichia coli at 9 mm, but the complexes and ampicillin inhibited four bacteria at 9–20 and 21–26 mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50 values of 28.18–54.19 and 9.66 μM against MCF-7 cells and 15.76–20.49 and 36.42 μM against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard.

Návaznosti

90242, velká výzkumná infrastruktura

Název: CIISB III

Citovat

WILLIEM, Ereny S., Ahmed B. M. IBRAHIM, S. ABD ELKHALIK, Jaromír MAREK a S. M. ABBAS. In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells. Future Medicinal Chemistry. Newlands Press Ltd, 2023, roč. 15, č. 15, s. 1415-1426. ISSN 1756-8919. Dostupné z: https://dx.doi.org/10.4155/fmc-2023-0190.

@article{2368527,
   author = {Williem, Ereny S. and Ibrahim, Ahmed B. M. and Abd Elkhalik, S. and Marek, Jaromír and Abbas, S. M.},
   article_number = {15},
   doi = {http://dx.doi.org/10.4155/fmc-2023-0190},
   keywords = {anionic ligands; breast cells; Candida albicans; Schiff bases; Staphylococcus aureus; tetrahedral},
   language = {eng},
   issn = {1756-8919},
   journal = {Future Medicinal Chemistry},
   title = {In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells},
   url = {https://www.future-science.com/doi/full/10.4155/fmc-2023-0190},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 2368527
AU  - Williem, Ereny S. - Ibrahim, Ahmed B. M. - Abd Elkhalik, S. - Marek, Jaromír - Abbas, S. M.
PY  - 2023
TI  - In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells
JF  - Future Medicinal Chemistry
VL  - 15
IS  - 15
SP  - 1415-1426
EP  - 1415-1426
PB  - Newlands Press Ltd
SN  - 17568919
KW  - anionic ligands
KW  - breast cells
KW  - Candida albicans
KW  - Schiff bases
KW  - Staphylococcus aureus
KW  - tetrahedral
UR  - https://www.future-science.com/doi/full/10.4155/fmc-2023-0190
N2  - Background: More studies using cobalt complexes as drugs are needed. Results: The drug action of two cobalt salicylaldimines was determined. The complexes and amphotericin B (20 mg/ml) inhibited Candida albicans at 9–15 and 21 mm. This concentration of both ligands inhibited Staphylococcus aureus at 10 mm and one ligand inhibited Escherichia coli at 9 mm, but the complexes and ampicillin inhibited four bacteria at 9–20 and 21–26 mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50 values of 28.18–54.19 and 9.66 μM against MCF-7 cells and 15.76–20.49 and 36.42 μM against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard.
ER  -

WILLIEM, Ereny S., Ahmed B. M. IBRAHIM, S. ABD ELKHALIK, Jaromír MAREK a S. M. ABBAS. In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells. \textit{Future Medicinal Chemistry}. Newlands Press Ltd, 2023, roč.~15, č.~15, s.~1415-1426. ISSN~1756-8919. Dostupné z: https://dx.doi.org/10.4155/fmc-2023-0190.

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