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@article{2368570, author = {Fait, Tomas and Baltazar, Tivadar and Bubeníčková, Leona and Kestranek, Jan and Stepan, Martin and Muller, Miroslav and Turcan, Pavel}, article_location = {Basel}, article_number = {19}, doi = {http://dx.doi.org/10.3390/jcm12196234}, keywords = {vaginal laxity; vulvovaginal laxity; nonsurgical vaginal tightening; incontinence; sexual function; urogenital distress; electroporation therapy}, language = {eng}, issn = {2077-0383}, journal = {Journal of Clinical Medicine}, title = {Treatment of Vulvovaginal Laxity by Electroporation: The Jett Plasma Medical for Her II Study}, url = {https://www.mdpi.com/2077-0383/12/19/6234}, volume = {12}, year = {2023} }
TY - JOUR ID - 2368570 AU - Fait, Tomas - Baltazar, Tivadar - Bubeníčková, Leona - Kestranek, Jan - Stepan, Martin - Muller, Miroslav - Turcan, Pavel PY - 2023 TI - Treatment of Vulvovaginal Laxity by Electroporation: The Jett Plasma Medical for Her II Study JF - Journal of Clinical Medicine VL - 12 IS - 19 SP - 1-12 EP - 1-12 PB - MDPI SN - 20770383 KW - vaginal laxity KW - vulvovaginal laxity KW - nonsurgical vaginal tightening KW - incontinence KW - sexual function KW - urogenital distress KW - electroporation therapy UR - https://www.mdpi.com/2077-0383/12/19/6234 N2 - Introduction: Vaginal laxity is a widespread and undertreated medical condition associated especially with vaginal parity. Aim: To evaluate the efficacy and safety of electroporation therapy treatment of vulvovaginal laxity by the Jett Plasma for Her II device. Methods: The Jett Plasma for Her II Study is a multicentric, prospective, randomized, single-blinded, and controlled study. Women presenting with vaginal laxity were randomized to receive electroporation therapy delivered to the vaginal tissue (active-82 patients) vs. therapy with zero intensity (placebo-9 patients). Results: A total of 91 subjects whose average age was 48.69 +/- 10.89 were included. Due to the results of a one-way analysis of variance, it may be concluded that in the case of the vaginal laxity questionnaire (VLQ), there is a statistically significant difference between actively treated patients and the placebo group (F-1,F-574 = 46.91; p < 0.001). In the case of the female sexual function index (FSFI), a one-way ANOVA test also showed a statistically significant difference between the actively treated patients and the placebo group (F-1,F-278 = 7.97; p = 0.005). In the case of the incontinence impact questionnaire-7 (IIQ-7), a one-way ANOVA test showed a statistically significant difference between the actively treated patients and the placebo group (F-1,F-384 = 15.51; p < 0.001). It confirms that improvement of vaginal laxity is conjoined with benefits in symptoms of urinary incontinence. Biopsy performed after the end of the treatment shows an increase in the vaginal mucosa thickness by an average of 100.04% in the active group. The treatment was well tolerated with no adverse events. No topical anesthetics were required. Conclusions: Treatments of vulvovaginal laxity by electroporation therapy achieved significant and sustainable 12-month effectiveness. Responses to the questionnaires also suggest subjective improvement in self-reported sexual function, incontinence, sexual satisfaction, and urogenital distress. ER -
FAIT, Tomas, Tivadar BALTAZAR, Leona BUBENÍČKOVÁ, Jan KESTRANEK, Martin STEPAN, Miroslav MULLER a Pavel TURCAN. Treatment of Vulvovaginal Laxity by Electroporation: The Jett Plasma Medical for Her II Study. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2023, roč.~12, č.~19, s.~1-12. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm12196234.
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