Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the epicovideha registry
Authors
MUSTO, Pellegrino; Jon SALMANTON-GARCIA; Nicola SGHERZA; Rui BERGANTIM; Francesca FARINA; Andreas GLENTHOJ; Cengiz Seval GULDANE; Barbora WEINBERGEROVÁ (203 Czech Republic, belonging to the institution); Valentina BONUOMO; Yavuz M BILGIN; van Doesum JAAP; Ozren JAKSIC; Benjamin VISEK; Iker FALCES-ROMERO; Monia MARCHETTI; Julio DAVILA-VALLS; Sonia MARTIN-PEREZ; Marcio NUCCI; Alberto LOPEZ-GARCIA; Federico ITRI; Caterina BUQUICCHIO; Luisa VERGA; Klara PIUKOVICS; Milan NAVRATIL; Graham P COLLINS; Moraima JIMENEZ; Nicola S FRACCHIOLLA; Jorge LABRADOR; Lucia PREZIOSO; Elena ROSSI; Natasha COLOVIC; Stef MEERS; Austin KULASEKARARAJ; Annarosa CUCCARO; Ola BLENNOW; Toni VALKOVIC; Uluhan SILI; Marie-Pierre LEDOUX; Josip BATINIC; Francesco PASSAMONTI; Marina MACHADO; Rafael F DUARTE; Christian Bjorn POULSEN; Gustavo-Adolfo MENDEZ; Ildefonso ESPIGADO; Fatih DEMIRKAN; Martin CERNAN; Chiara CATTANEO; Verena PETZER; Gabriele MAGLIANO; Carolina GARCIA-VIDAL; Shaimaa EL-ASHWAH; Maria GOMES-DA-SILVA; Antonio VENA; Irati ORMAZABAL-VELEZ; van Praet JENS; Michelina DARGENIO; Cristina DE-RAMON; Del Principe Maria ILARIA; Joyce MARQUES-DE-ALMEIDA; Dominik WOLF; Tomas SZOTKOWSKI; Ales OBR; Goekce Melis COLAK; Anna NORDLANDER; Macarena IZUZQUIZA; Alba CABIRTA; Giovanni Paolo Maria ZAMBROTTA; Raul CORDOBA; Pavel ZAK; Emanuele AMMATUNA; Jiri MAYER; Osman ILHAN; Ramon GARCIA-SANZ; Martina QUATTRONE; Elena ARELLANO; Raquel NUNES-RODRIGUES; Ziad EMARAH; Tommaso Francesco AIELLO; Michaela HANAKOVA; Zdenek RACIL; Martina BAVASTRO; Alessandro LIMONGELLI; Laman RAHIMLI; Francesco MARCHESI; Oliver A CORNELY and Livio PAGANO
Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world. Median follow-up was 52 days for the entire cohort and 83 days for survivors. Three-hundred and three patients died (24%) and COVID-19 was the primary reason for death of around 89% of them. Overall survival (OS) was significantly higher in vaccinated patients with both stable and active MM versus unvaccinated, while only a trend favoring vaccinated patients was observed in subjects with responsive MM. Vaccinated patients with at least 2 doses showed a better OS than those with one or no vaccine dose. Overall, according to pandemic waves, mortality rate decreased over time from 34% to 10%. In multivariable analysis, age, renal failure, active disease, hospital, and intensive care unit admission, were independently associated with a higher number of deaths, while a neutrophil count above 0.5 x 109/L was found to be protective. This data suggests that MM patients remain at risk of SARS-CoV-2 infection even in the vaccination era, but their clinical outcome, in terms of OS, has progressively improved throughout the different viral phases of the pandemic.
MUSTO, Pellegrino; Jon SALMANTON-GARCIA; Nicola SGHERZA; Rui BERGANTIM; Francesca FARINA; Andreas GLENTHOJ; Cengiz Seval GULDANE; Barbora WEINBERGEROVÁ; Valentina BONUOMO; Yavuz M BILGIN; van Doesum JAAP; Ozren JAKSIC; Benjamin VISEK; Iker FALCES-ROMERO; Monia MARCHETTI; Julio DAVILA-VALLS; Sonia MARTIN-PEREZ; Marcio NUCCI; Alberto LOPEZ-GARCIA; Federico ITRI; Caterina BUQUICCHIO; Luisa VERGA; Klara PIUKOVICS; Milan NAVRATIL; Graham P COLLINS; Moraima JIMENEZ; Nicola S FRACCHIOLLA; Jorge LABRADOR; Lucia PREZIOSO; Elena ROSSI; Natasha COLOVIC; Stef MEERS; Austin KULASEKARARAJ; Annarosa CUCCARO; Ola BLENNOW; Toni VALKOVIC; Uluhan SILI; Marie-Pierre LEDOUX; Josip BATINIC; Francesco PASSAMONTI; Marina MACHADO; Rafael F DUARTE; Christian Bjorn POULSEN; Gustavo-Adolfo MENDEZ; Ildefonso ESPIGADO; Fatih DEMIRKAN; Martin CERNAN; Chiara CATTANEO; Verena PETZER; Gabriele MAGLIANO; Carolina GARCIA-VIDAL; Shaimaa EL-ASHWAH; Maria GOMES-DA-SILVA; Antonio VENA; Irati ORMAZABAL-VELEZ; van Praet JENS; Michelina DARGENIO; Cristina DE-RAMON; Del Principe Maria ILARIA; Joyce MARQUES-DE-ALMEIDA; Dominik WOLF; Tomas SZOTKOWSKI; Ales OBR; Goekce Melis COLAK; Anna NORDLANDER; Macarena IZUZQUIZA; Alba CABIRTA; Giovanni Paolo Maria ZAMBROTTA; Raul CORDOBA; Pavel ZAK; Emanuele AMMATUNA; Jiri MAYER; Osman ILHAN; Ramon GARCIA-SANZ; Martina QUATTRONE; Elena ARELLANO; Raquel NUNES-RODRIGUES; Ziad EMARAH; Tommaso Francesco AIELLO; Michaela HANAKOVA; Zdenek RACIL; Martina BAVASTRO; Alessandro LIMONGELLI; Laman RAHIMLI; Francesco MARCHESI; Oliver A CORNELY and Livio PAGANO. Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the epicovideha registry. Hematological Oncology. Hoboken: WILEY-BLACKWELL, 2024, vol. 42, No 1, p. 1-15. ISSN 0278-0232. Available from: https://dx.doi.org/10.1002/hon.3240.
@article{2368919, author = {Musto, Pellegrino and SalmantonandGarcia, Jon and Sgherza, Nicola and Bergantim, Rui and Farina, Francesca and Glenthoj, Andreas and Guldane, Cengiz Seval and Weinbergerová, Barbora and Bonuomo, Valentina and Bilgin, Yavuz M and Jaap, van Doesum and Jaksic, Ozren and Visek, Benjamin and FalcesandRomero, Iker and Marchetti, Monia and DavilaandValls, Julio and MartinandPerez, Sonia and Nucci, Marcio and LopezandGarcia, Alberto and Itri, Federico and Buquicchio, Caterina and Verga, Luisa and Piukovics, Klara and Navratil, Milan and Collins, Graham P and Jimenez, Moraima and Fracchiolla, Nicola S and Labrador, Jorge and Prezioso, Lucia and Rossi, Elena and Colovic, Natasha and Meers, Stef and Kulasekararaj, Austin and Cuccaro, Annarosa and Blennow, Ola and Valkovic, Toni and Sili, Uluhan and Ledoux, MarieandPierre and Batinic, Josip and Passamonti, Francesco and Machado, Marina and Duarte, Rafael F and Poulsen, Christian Bjorn and Mendez, GustavoandAdolfo and Espigado, Ildefonso and Demirkan, Fatih and Cernan, Martin and Cattaneo, Chiara and Petzer, Verena and Magliano, Gabriele and GarciaandVidal, Carolina and ElandAshwah, Shaimaa and GomesandDaandSilva, Maria and Vena, Antonio and OrmazabalandVelez, Irati and Jens, van Praet and Dargenio, Michelina and DeandRamon, Cristina and Ilaria, Del Principe Maria and MarquesandDeandAlmeida, Joyce and Wolf, Dominik and Szotkowski, Tomas and Obr, Ales and Colak, Goekce Melis and Nordlander, Anna and Izuzquiza, Macarena and Cabirta, Alba and Zambrotta, Giovanni Paolo Maria and Cordoba, Raul and Zak, Pavel and Ammatuna, Emanuele and Mayer, Jiri and Ilhan, Osman and GarciaandSanz, Ramon and Quattrone, Martina and Arellano, Elena and NunesandRodrigues, Raquel and Emarah, Ziad and Aiello, Tommaso Francesco and Hanakova, Michaela and Racil, Zdenek and Bavastro, Martina and Limongelli, Alessandro and Rahimli, Laman and Marchesi, Francesco and Cornely, Oliver A and Pagano, Livio}, article_location = {Hoboken}, article_number = {1}, doi = {http://dx.doi.org/10.1002/hon.3240}, keywords = {COVID-19; hematological malignancy; multiple myeloma; SARS-CoV-2}, language = {eng}, issn = {0278-0232}, journal = {Hematological Oncology}, title = {Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the epicovideha registry}, url = {https://onlinelibrary.wiley.com/doi/10.1002/hon.3240}, volume = {42}, year = {2024} }
TY - JOUR ID - 2368919 AU - Musto, Pellegrino - Salmanton-Garcia, Jon - Sgherza, Nicola - Bergantim, Rui - Farina, Francesca - Glenthoj, Andreas - Guldane, Cengiz Seval - Weinbergerová, Barbora - Bonuomo, Valentina - Bilgin, Yavuz M - Jaap, van Doesum - Jaksic, Ozren - Visek, Benjamin - Falces-Romero, Iker - Marchetti, Monia - Davila-Valls, Julio - Martin-Perez, Sonia - Nucci, Marcio - Lopez-Garcia, Alberto - Itri, Federico - Buquicchio, Caterina - Verga, Luisa - Piukovics, Klara - Navratil, Milan - Collins, Graham P - Jimenez, Moraima - Fracchiolla, Nicola S - Labrador, Jorge - Prezioso, Lucia - Rossi, Elena - Colovic, Natasha - Meers, Stef - Kulasekararaj, Austin - Cuccaro, Annarosa - Blennow, Ola - Valkovic, Toni - Sili, Uluhan - Ledoux, Marie-Pierre - Batinic, Josip - Passamonti, Francesco - Machado, Marina - Duarte, Rafael F - Poulsen, Christian Bjorn - Mendez, Gustavo-Adolfo - Espigado, Ildefonso - Demirkan, Fatih - Cernan, Martin - Cattaneo, Chiara - Petzer, Verena - Magliano, Gabriele - Garcia-Vidal, Carolina - El-Ashwah, Shaimaa - Gomes-Da-Silva, Maria - Vena, Antonio - Ormazabal-Velez, Irati - Jens, van Praet - Dargenio, Michelina - De-Ramon, Cristina - Ilaria, Del Principe Maria - Marques-De-Almeida, Joyce - Wolf, Dominik - Szotkowski, Tomas - Obr, Ales - Colak, Goekce Melis - Nordlander, Anna - Izuzquiza, Macarena - Cabirta, Alba - Zambrotta, Giovanni Paolo Maria - Cordoba, Raul - Zak, Pavel - Ammatuna, Emanuele - Mayer, Jiri - Ilhan, Osman - Garcia-Sanz, Ramon - Quattrone, Martina - Arellano, Elena - Nunes-Rodrigues, Raquel - Emarah, Ziad - Aiello, Tommaso Francesco - Hanakova, Michaela - Racil, Zdenek - Bavastro, Martina - Limongelli, Alessandro - Rahimli, Laman - Marchesi, Francesco - Cornely, Oliver A - Pagano, Livio PY - 2024 TI - Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the epicovideha registry JF - Hematological Oncology VL - 42 IS - 1 SP - 1-15 EP - 1-15 PB - WILEY-BLACKWELL SN - 02780232 KW - COVID-19 KW - hematological malignancy KW - multiple myeloma KW - SARS-CoV-2 UR - https://onlinelibrary.wiley.com/doi/10.1002/hon.3240 N2 - Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world. Median follow-up was 52 days for the entire cohort and 83 days for survivors. Three-hundred and three patients died (24%) and COVID-19 was the primary reason for death of around 89% of them. Overall survival (OS) was significantly higher in vaccinated patients with both stable and active MM versus unvaccinated, while only a trend favoring vaccinated patients was observed in subjects with responsive MM. Vaccinated patients with at least 2 doses showed a better OS than those with one or no vaccine dose. Overall, according to pandemic waves, mortality rate decreased over time from 34% to 10%. In multivariable analysis, age, renal failure, active disease, hospital, and intensive care unit admission, were independently associated with a higher number of deaths, while a neutrophil count above 0.5 x 109/L was found to be protective. This data suggests that MM patients remain at risk of SARS-CoV-2 infection even in the vaccination era, but their clinical outcome, in terms of OS, has progressively improved throughout the different viral phases of the pandemic. ER -
MUSTO, Pellegrino; Jon SALMANTON-GARCIA; Nicola SGHERZA; Rui BERGANTIM; Francesca FARINA; Andreas GLENTHOJ; Cengiz Seval GULDANE; Barbora WEINBERGEROVÁ; Valentina BONUOMO; Yavuz M BILGIN; van Doesum JAAP; Ozren JAKSIC; Benjamin VISEK; Iker FALCES-ROMERO; Monia MARCHETTI; Julio DAVILA-VALLS; Sonia MARTIN-PEREZ; Marcio NUCCI; Alberto LOPEZ-GARCIA; Federico ITRI; Caterina BUQUICCHIO; Luisa VERGA; Klara PIUKOVICS; Milan NAVRATIL; Graham P COLLINS; Moraima JIMENEZ; Nicola S FRACCHIOLLA; Jorge LABRADOR; Lucia PREZIOSO; Elena ROSSI; Natasha COLOVIC; Stef MEERS; Austin KULASEKARARAJ; Annarosa CUCCARO; Ola BLENNOW; Toni VALKOVIC; Uluhan SILI; Marie-Pierre LEDOUX; Josip BATINIC; Francesco PASSAMONTI; Marina MACHADO; Rafael F DUARTE; Christian Bjorn POULSEN; Gustavo-Adolfo MENDEZ; Ildefonso ESPIGADO; Fatih DEMIRKAN; Martin CERNAN; Chiara CATTANEO; Verena PETZER; Gabriele MAGLIANO; Carolina GARCIA-VIDAL; Shaimaa EL-ASHWAH; Maria GOMES-DA-SILVA; Antonio VENA; Irati ORMAZABAL-VELEZ; van Praet JENS; Michelina DARGENIO; Cristina DE-RAMON; Del Principe Maria ILARIA; Joyce MARQUES-DE-ALMEIDA; Dominik WOLF; Tomas SZOTKOWSKI; Ales OBR; Goekce Melis COLAK; Anna NORDLANDER; Macarena IZUZQUIZA; Alba CABIRTA; Giovanni Paolo Maria ZAMBROTTA; Raul CORDOBA; Pavel ZAK; Emanuele AMMATUNA; Jiri MAYER; Osman ILHAN; Ramon GARCIA-SANZ; Martina QUATTRONE; Elena ARELLANO; Raquel NUNES-RODRIGUES; Ziad EMARAH; Tommaso Francesco AIELLO; Michaela HANAKOVA; Zdenek RACIL; Martina BAVASTRO; Alessandro LIMONGELLI; Laman RAHIMLI; Francesco MARCHESI; Oliver A CORNELY and Livio PAGANO. Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the epicovideha registry. \textit{Hematological Oncology}. Hoboken: WILEY-BLACKWELL, 2024, vol.~42, No~1, p.~1-15. ISSN~0278-0232. Available from: https://dx.doi.org/10.1002/hon.3240.