Consensus Paper: Cerebellum and Ageing

J 2024

Consensus Paper: Cerebellum and Ageing

ARLEO, Angelo, Martin BAREŠ, Jessica A BERNARD, Hannah R BOGOIAN, Muriel M K BRUCHHAGE et. al.

Základní údaje

Originální název

Consensus Paper: Cerebellum and Ageing

Autoři

ARLEO, Angelo, Martin BAREŠ (203 Česká republika, domácí), Jessica A BERNARD, Hannah R BOGOIAN, Muriel M K BRUCHHAGE, Patrick BRYANT, Erik S CARLSON, Chetwyn C H CHAN, Liang-Kung CHEN, Chih-Ping CHUNG, Vonetta M DOTSON, Pavel FILIP, Xavier GUELL, Christophe HABAS, Heidi I L JACOBS, Shinji KAKEI, Tatia M C LEE, Maria LEGGIO, Maria MISIURA, Hiroshi MITOMA, Giusy OLIVITO, Stephen RAMANOEL, Zeynab REZAEE, Colby L SAMSTAG, Jeremy D SCHMAHMANN, Kaoru SEKIYAMA, Clive H Y WONG, Masatoshi YAMASHITA a Mario MANTO

Vydání

Cerebellum, New York, Springer, 2024, 1473-4222

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.500 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s12311-023-01577-7

UT WoS

001026192700001

Klíčová slova anglicky

Cerebellum; Aging; Motor; Cognitive; Affective; Alzheimer's Disease

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 7. 2024 12:52, Mgr. Tereza Miškechová

Anotace

V originále

Given the key roles of the cerebellum in motor, cognitive, and affective operations and given the decline of brain functions with aging, cerebellar circuitry is attracting the attention of the scientific community. The cerebellum plays a key role in timing aspects of both motor and cognitive operations, including for complex tasks such as spatial navigation. Anatomically, the cerebellum is connected with the basal ganglia via disynaptic loops, and it receives inputs from nearly every region in the cerebral cortex. The current leading hypothesis is that the cerebellum builds internal models and facilitates automatic behaviors through multiple interactions with the cerebral cortex, basal ganglia and spinal cord. The cerebellum undergoes structural and functional changes with aging, being involved in mobility frailty and related cognitive impairment as observed in the physio-cognitive decline syndrome (PCDS) affecting older, functionally-preserved adults who show slowness and/or weakness. Reductions in cerebellar volume accompany aging and are at least correlated with cognitive decline. There is a strongly negative correlation between cerebellar volume and age in cross-sectional studies, often mirrored by a reduced performance in motor tasks. Still, predictive motor timing scores remain stable over various age groups despite marked cerebellar atrophy. The cerebello-frontal network could play a significant role in processing speed and impaired cerebellar function due to aging might be compensated by increasing frontal activity to optimize processing speed in the elderly. For cognitive operations, decreased functional connectivity of the default mode network (DMN) is correlated with lower performances. Neuroimaging studies highlight that the cerebellum might be involved in the cognitive decline occurring in Alzheimer's disease (AD), independently of contributions of the cerebral cortex. Grey matter volume loss in AD is distinct from that seen in normal aging, occurring initially in cerebellar posterior lobe regions, and is associated with neuronal, synaptic and beta-amyloid neuropathology. Regarding depression, structural imaging studies have identified a relationship between depressive symptoms and cerebellar gray matter volume. In particular, major depressive disorder (MDD) and higher depressive symptom burden are associated with smaller gray matter volumes in the total cerebellum as well as the posterior cerebellum, vermis, and posterior Crus I. From the genetic/epigenetic standpoint, prominent DNA methylation changes in the cerebellum with aging are both in the form of hypo- and hyper-methylation, and the presumably increased/decreased expression of certain genes might impact on motor coordination. Training influences motor skills and lifelong practice might contribute to structural maintenance of the cerebellum in old age, reducing loss of grey matter volume and therefore contributing to the maintenance of cerebellar reserve. Non-invasive cerebellar stimulation techniques are increasingly being applied to enhance cerebellar functions related to motor, cognitive, and affective operations. They might enhance cerebellar reserve in the elderly. In conclusion, macroscopic and microscopic changes occur in the cerebellum during the lifespan, with changes in structural and functional connectivity with both the cerebral cortex and basal ganglia.

Citovat

ARLEO, Angelo, Martin BAREŠ, Jessica A BERNARD, Hannah R BOGOIAN, Muriel M K BRUCHHAGE, Patrick BRYANT, Erik S CARLSON, Chetwyn C H CHAN, Liang-Kung CHEN, Chih-Ping CHUNG, Vonetta M DOTSON, Pavel FILIP, Xavier GUELL, Christophe HABAS, Heidi I L JACOBS, Shinji KAKEI, Tatia M C LEE, Maria LEGGIO, Maria MISIURA, Hiroshi MITOMA, Giusy OLIVITO, Stephen RAMANOEL, Zeynab REZAEE, Colby L SAMSTAG, Jeremy D SCHMAHMANN, Kaoru SEKIYAMA, Clive H Y WONG, Masatoshi YAMASHITA a Mario MANTO. Consensus Paper: Cerebellum and Ageing. Cerebellum. New York: Springer, 2024, roč. 23, č. 2, s. 802-832. ISSN 1473-4222. Dostupné z: https://dx.doi.org/10.1007/s12311-023-01577-7.

@article{2369021,
   author = {Arleo, Angelo and Bareš, Martin and Bernard, Jessica A and Bogoian, Hannah R and Bruchhage, Muriel M K and Bryant, Patrick and Carlson, Erik S and Chan, Chetwyn C H and Chen, LiangandKung and Chung, ChihandPing and Dotson, Vonetta M and Filip, Pavel and Guell, Xavier and Habas, Christophe and Jacobs, Heidi I L and Kakei, Shinji and Lee, Tatia M C and Leggio, Maria and Misiura, Maria and Mitoma, Hiroshi and Olivito, Giusy and Ramanoel, Stephen and Rezaee, Zeynab and Samstag, Colby L and Schmahmann, Jeremy D and Sekiyama, Kaoru and Wong, Clive H Y and Yamashita, Masatoshi and Manto, Mario},
   article_location = {New York},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s12311-023-01577-7},
   keywords = {Cerebellum; Aging; Motor; Cognitive; Affective; Alzheimer's Disease},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {Consensus Paper: Cerebellum and Ageing},
   url = {https://link.springer.com/article/10.1007/s12311-023-01577-7},
   volume = {23},
   year = {2024}
}

TY  - JOUR
ID  - 2369021
AU  - Arleo, Angelo - Bareš, Martin - Bernard, Jessica A - Bogoian, Hannah R - Bruchhage, Muriel M K - Bryant, Patrick - Carlson, Erik S - Chan, Chetwyn C H - Chen, Liang-Kung - Chung, Chih-Ping - Dotson, Vonetta M - Filip, Pavel - Guell, Xavier - Habas, Christophe - Jacobs, Heidi I L - Kakei, Shinji - Lee, Tatia M C - Leggio, Maria - Misiura, Maria - Mitoma, Hiroshi - Olivito, Giusy - Ramanoel, Stephen - Rezaee, Zeynab - Samstag, Colby L - Schmahmann, Jeremy D - Sekiyama, Kaoru - Wong, Clive H Y - Yamashita, Masatoshi - Manto, Mario
PY  - 2024
TI  - Consensus Paper: Cerebellum and Ageing
JF  - Cerebellum
VL  - 23
IS  - 2
SP  - 802-832
EP  - 802-832
PB  - Springer
SN  - 14734222
KW  - Cerebellum
KW  - Aging
KW  - Motor
KW  - Cognitive
KW  - Affective
KW  - Alzheimer's Disease
UR  - https://link.springer.com/article/10.1007/s12311-023-01577-7
N2  - Given the key roles of the cerebellum in motor, cognitive, and affective operations and given the decline of brain functions with aging, cerebellar circuitry is attracting the attention of the scientific community. The cerebellum plays a key role in timing aspects of both motor and cognitive operations, including for complex tasks such as spatial navigation. Anatomically, the cerebellum is connected with the basal ganglia via disynaptic loops, and it receives inputs from nearly every region in the cerebral cortex. The current leading hypothesis is that the cerebellum builds internal models and facilitates automatic behaviors through multiple interactions with the cerebral cortex, basal ganglia and spinal cord. The cerebellum undergoes structural and functional changes with aging, being involved in mobility frailty and related cognitive impairment as observed in the physio-cognitive decline syndrome (PCDS) affecting older, functionally-preserved adults who show slowness and/or weakness. Reductions in cerebellar volume accompany aging and are at least correlated with cognitive decline. There is a strongly negative correlation between cerebellar volume and age in cross-sectional studies, often mirrored by a reduced performance in motor tasks. Still, predictive motor timing scores remain stable over various age groups despite marked cerebellar atrophy. The cerebello-frontal network could play a significant role in processing speed and impaired cerebellar function due to aging might be compensated by increasing frontal activity to optimize processing speed in the elderly. For cognitive operations, decreased functional connectivity of the default mode network (DMN) is correlated with lower performances. Neuroimaging studies highlight that the cerebellum might be involved in the cognitive decline occurring in Alzheimer's disease (AD), independently of contributions of the cerebral cortex. Grey matter volume loss in AD is distinct from that seen in normal aging, occurring initially in cerebellar posterior lobe regions, and is associated with neuronal, synaptic and beta-amyloid neuropathology. Regarding depression, structural imaging studies have identified a relationship between depressive symptoms and cerebellar gray matter volume. In particular, major depressive disorder (MDD) and higher depressive symptom burden are associated with smaller gray matter volumes in the total cerebellum as well as the posterior cerebellum, vermis, and posterior Crus I. From the genetic/epigenetic standpoint, prominent DNA methylation changes in the cerebellum with aging are both in the form of hypo- and hyper-methylation, and the presumably increased/decreased expression of certain genes might impact on motor coordination. Training influences motor skills and lifelong practice might contribute to structural maintenance of the cerebellum in old age, reducing loss of grey matter volume and therefore contributing to the maintenance of cerebellar reserve. Non-invasive cerebellar stimulation techniques are increasingly being applied to enhance cerebellar functions related to motor, cognitive, and affective operations. They might enhance cerebellar reserve in the elderly. In conclusion, macroscopic and microscopic changes occur in the cerebellum during the lifespan, with changes in structural and functional connectivity with both the cerebral cortex and basal ganglia.
ER  -

ARLEO, Angelo, Martin BAREŠ, Jessica A BERNARD, Hannah R BOGOIAN, Muriel M K BRUCHHAGE, Patrick BRYANT, Erik S CARLSON, Chetwyn C H CHAN, Liang-Kung CHEN, Chih-Ping CHUNG, Vonetta M DOTSON, Pavel FILIP, Xavier GUELL, Christophe HABAS, Heidi I L JACOBS, Shinji KAKEI, Tatia M C LEE, Maria LEGGIO, Maria MISIURA, Hiroshi MITOMA, Giusy OLIVITO, Stephen RAMANOEL, Zeynab REZAEE, Colby L SAMSTAG, Jeremy D SCHMAHMANN, Kaoru SEKIYAMA, Clive H Y WONG, Masatoshi YAMASHITA a Mario MANTO. Consensus Paper: Cerebellum and Ageing. \textit{Cerebellum}. New York: Springer, 2024, roč.~23, č.~2, s.~802-832. ISSN~1473-4222. Dostupné z: https://dx.doi.org/10.1007/s12311-023-01577-7.

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