| CHITADZE, Guranda, Anna STENGEL, Cathrin JOHN-KLAUA, Julien BRUCKMUELLER, Heiko TRAUTMANN, Michaela KOTROVA, Franziska DARZENTAS, Miriam KELM, Karol PÁL, Nikos DARZENTAS, Lorenz BASTIAN, Britta KEHDEN, Wiebke WESSELS, Aeint-Steffen STROEH, Hans -Heinrich OBERG, Philipp M ALTROCK, Constance BAER, Manja MEGGENDORFER, Nicola GOEKBUGET, Claudia D BALDUS, Claudia HAFERLACH a Monika BRUEGGEMANN. Somatic <i>TP53</i> mutations are preleukemic events in acute lymphoblastic leukemia. Blood. Washington DC, USA: American Society of Hematology, 2023, roč. 141, č. 13, s. 1640-1644. ISSN 0006-4971. Dostupné z: https://dx.doi.org/10.1182/blood.2022017249. |
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@article{2369681,
author = {Chitadze, Guranda and Stengel, Anna and JohnandKlaua, Cathrin and Bruckmueller, Julien and Trautmann, Heiko and Kotrova, Michaela and Darzentas, Franziska and Kelm, Miriam and Pál, Karol and Darzentas, Nikos and Bastian, Lorenz and Kehden, Britta and Wessels, Wiebke and Stroeh, AeintandSteffen and Oberg, Hans andHeinrich and Altrock, Philipp M and Baer, Constance and Meggendorfer, Manja and Goekbuget, Nicola and Baldus, Claudia D and Haferlach, Claudia and Brueggemann, Monika},
article_location = {Washington DC, USA},
article_number = {13},
doi = {http://dx.doi.org/10.1182/blood.2022017249},
keywords = {Acute lymphoblastic leukemia; gene TP53v mutations},
language = {eng},
issn = {0006-4971},
journal = {Blood},
title = {Somatic <i>TP53</i> mutations are preleukemic events in acute lymphoblastic leukemia},
url = {https://ashpublications.org/blood/article/141/13/1640/493383/Somatic-TP53-mutations-are-preleukemic-events-in},
volume = {141},
year = {2023}
}
TY - JOUR
ID - 2369681
AU - Chitadze, Guranda - Stengel, Anna - John-Klaua, Cathrin - Bruckmueller, Julien - Trautmann, Heiko - Kotrova, Michaela - Darzentas, Franziska - Kelm, Miriam - Pál, Karol - Darzentas, Nikos - Bastian, Lorenz - Kehden, Britta - Wessels, Wiebke - Stroeh, Aeint-Steffen - Oberg, Hans -Heinrich - Altrock, Philipp M - Baer, Constance - Meggendorfer, Manja - Goekbuget, Nicola - Baldus, Claudia D - Haferlach, Claudia - Brueggemann, Monika
PY - 2023
TI - Somatic <i>TP53</i> mutations are preleukemic events in acute lymphoblastic leukemia
JF - Blood
VL - 141
IS - 13
SP - 1640-1644
EP - 1640-1644
PB - American Society of Hematology
SN - 00064971
KW - Acute lymphoblastic leukemia
KW - gene TP53v mutations
UR - https://ashpublications.org/blood/article/141/13/1640/493383/Somatic-TP53-mutations-are-preleukemic-events-in
N2 - Acute lymphoblastic leukemia (ALL) is an aggressive hematological malignancy with especially dismal outcomes in adults and at the recurrence of the disease. Somatic mutations in the tumor suppressor gene TP53 occur in 6% to 19% of ALL cases at diagnosis and are enriched in low hypodiploid-near triploid ALL and at reoccurrence of the disease. TP53 mutations in ALL play an important role in the evolution of treatment-resistant clones, associated with early relapses and poor overall survival. Furthermore, TP53 mutations have been reported as an early leukemogenic event in patients with acute myeloid leukemia, representing acute myeloid leukemia-initiating mutations and mediators of resistant disease, even at subclonal levels. However, for ALL, very limited data are available. Here, we retrospectively analyzed the kinetics of TP53 mutations in the bone marrow and peripheral blood during follow-up in a group of 43 adult patients with TP53-mutated ALL and compared the TP53 mutation burden with minimal residual disease (MRD) levels assessed by EuroMRD-standardized real-time quantitative polymerase chain reaction (PCR) of clonal immune gene rearrangements (IG/TR MRD).
ER -
CHITADZE, Guranda, Anna STENGEL, Cathrin JOHN-KLAUA, Julien BRUCKMUELLER, Heiko TRAUTMANN, Michaela KOTROVA, Franziska DARZENTAS, Miriam KELM, Karol PÁL, Nikos DARZENTAS, Lorenz BASTIAN, Britta KEHDEN, Wiebke WESSELS, Aeint-Steffen STROEH, Hans -Heinrich OBERG, Philipp M ALTROCK, Constance BAER, Manja MEGGENDORFER, Nicola GOEKBUGET, Claudia D BALDUS, Claudia HAFERLACH a Monika BRUEGGEMANN. Somatic \&{}lt;i\&{}gt;TP53\&{}lt;/i\&{}gt; mutations are preleukemic events in acute lymphoblastic leukemia. \textit{Blood}. Washington DC, USA: American Society of Hematology, 2023, roč.~141, č.~13, s.~1640-1644. ISSN~0006-4971. Dostupné z: https://dx.doi.org/10.1182/blood.2022017249.
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