Cisplatin treatment reduces contraction to angiotensin II by
altering expression of angiotensin II receptors: a pilot study

J 2023

Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study

MCSWEENEY, Kristen Renee, Laura Kate GADANEC, Peter KUBATKA, Martin CAPRNA, Ludovit GASPAR et. al.

Základní údaje

Originální název

Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study

Autoři

MCSWEENEY, Kristen Renee (36 Austrálie), Laura Kate GADANEC (36 Austrálie), Peter KUBATKA (703 Slovensko), Martin CAPRNA (703 Slovensko), Ludovit GASPAR (703 Slovensko), Robert PROSECKÝ (203 Česká republika, domácí), Delian DELEV (100 Bulharsko), Peter KRUŽLIAK (703 Slovensko, domácí), Vasso APOSTOLOPOULOS (36 Austrálie) a Anthony ZULLI (36 Austrálie, garant)

Vydání

MOLECULAR AND CELLULAR BIOCHEMISTRY, NETHERLANDS, SPRINGER, 2023, 0300-8177

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Fulltext na stránkách vydavatele

Impakt faktor

Impact factor: 4.300 v roce 2022

Kód RIV

RIV/00216224:14110/23:00133476

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s11010-023-04706-2

UT WoS

001099394000023

Klíčová slova anglicky

Angiotensin II; Angiotensin type 1 receptor; Angiotensin type 2 receptor; Cisplatin; Contraction; Renin angiotensin system

Štítky

14110116, 14110121, rivok

Změněno: 29. 2. 2024 13:41, Mgr. Tereza Miškechová

Anotace

V originále

The renin angiotensin system is a key regulator of blood pressure homeostasis. Angiotensin type 1 (AT1R) and 2 receptors (AT2R) have been investigated as targets for cisplatin-induced acute kidney injury; however, their therapeutic potential remains inconclusive. This pilot study aimed to determined the effect that acute cisplatin treatment had on angiotensin II (AngII)-induced contraction in blood vessels and expression profiles of AT1R and AT2R in mouse arteries and kidneys. Male C57BL/6 mice at 18 week of age (n = 8) were treated with vehicle or bolus dose of cisplatin (12.5 mg/kg). Thoracic aorta (TA), adnominal aorta (AA), brachiocephalic arteries (BC), iliac arteries (IL) and kidneys were collected for isometric tension and immunohistochemistry analysis. Cisplatin treatment reduced IL contraction to AngII at all doses (p < 0.01, p < 0.001, p < 0.0001); however, AngII did not induce contraction in TA, AA or BC in either treatment group. Following cisplatin treatment, AT1R expression was significantly upregulated in the media of TA (p < 0.0001) and AA (p < 0.0001), and in the endothelium (p < 0.05) media (p < 0.0001) and adventitia (p < 0.01) of IL. Cisplatin treatment significantly reduced AT2R expression in the endothelium (p < 0.05) and media (p < 0.05) of TA. In renal tubules, both AT1R (p < 0.01) and AT2R (p < 0.05) were increased following cisplatin treatment. Herein, we report that cisplatin reduces AngII-mediated contraction in IL and may be explained by an absence of normal counterregulatory expression of AT1R and AT2R, indicating other factors are involved.

Citovat

MCSWEENEY, Kristen Renee, Laura Kate GADANEC, Peter KUBATKA, Martin CAPRNA, Ludovit GASPAR, Robert PROSECKÝ, Delian DELEV, Peter KRUŽLIAK, Vasso APOSTOLOPOULOS a Anthony ZULLI. Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study. MOLECULAR AND CELLULAR BIOCHEMISTRY. NETHERLANDS: SPRINGER, 2023, roč. 478, č. 12, s. 2907-2916. ISSN 0300-8177. Dostupné z: https://dx.doi.org/10.1007/s11010-023-04706-2.

@article{2370981,
   author = {McSweeney, Kristen Renee and Gadanec, Laura Kate and Kubatka, Peter and Caprna, Martin and Gaspar, Ludovit and Prosecký, Robert and Delev, Delian and Kružliak, Peter and Apostolopoulos, Vasso and Zulli, Anthony},
   article_location = {NETHERLANDS},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s11010-023-04706-2},
   keywords = {Angiotensin II; Angiotensin type 1 receptor; Angiotensin type 2 receptor; Cisplatin; Contraction; Renin angiotensin system},
   language = {eng},
   issn = {0300-8177},
   journal = {MOLECULAR AND CELLULAR BIOCHEMISTRY},
   title = {Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study},
   url = {https://link.springer.com/article/10.1007/s11010-023-04706-2},
   volume = {478},
   year = {2023}
}

TY  - JOUR
ID  - 2370981
AU  - McSweeney, Kristen Renee - Gadanec, Laura Kate - Kubatka, Peter - Caprna, Martin - Gaspar, Ludovit - Prosecký, Robert - Delev, Delian - Kružliak, Peter - Apostolopoulos, Vasso - Zulli, Anthony
PY  - 2023
TI  - Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study
JF  - MOLECULAR AND CELLULAR BIOCHEMISTRY
VL  - 478
IS  - 12
SP  - 2907-2916
EP  - 2907-2916
PB  - SPRINGER
SN  - 03008177
KW  - Angiotensin II
KW  - Angiotensin type 1 receptor
KW  - Angiotensin type 2 receptor
KW  - Cisplatin
KW  - Contraction
KW  - Renin angiotensin system
UR  - https://link.springer.com/article/10.1007/s11010-023-04706-2
N2  - The renin angiotensin system is a key regulator of blood pressure homeostasis. Angiotensin type 1 (AT1R) and 2 receptors (AT2R) have been investigated as targets for cisplatin-induced acute kidney injury; however, their therapeutic potential remains inconclusive. This pilot study aimed to determined the effect that acute cisplatin treatment had on angiotensin II (AngII)-induced contraction in blood vessels and expression profiles of AT1R and AT2R in mouse arteries and kidneys. Male C57BL/6 mice at 18 week of age (n = 8) were treated with vehicle or bolus dose of cisplatin (12.5 mg/kg). Thoracic aorta (TA), adnominal aorta (AA), brachiocephalic arteries (BC), iliac arteries (IL) and kidneys were collected for isometric tension and immunohistochemistry analysis. Cisplatin treatment reduced IL contraction to AngII at all doses (p < 0.01, p < 0.001, p < 0.0001); however, AngII did not induce contraction in TA, AA or BC in either treatment group. Following cisplatin treatment, AT1R expression was significantly upregulated in the media of TA (p < 0.0001) and AA (p < 0.0001), and in the endothelium (p < 0.05) media (p < 0.0001) and adventitia (p < 0.01) of IL. Cisplatin treatment significantly reduced AT2R expression in the endothelium (p < 0.05) and media (p < 0.05) of TA. In renal tubules, both AT1R (p < 0.01) and AT2R (p < 0.05) were increased following cisplatin treatment. Herein, we report that cisplatin reduces AngII-mediated contraction in IL and may be explained by an absence of normal counterregulatory expression of AT1R and AT2R, indicating other factors are involved.
ER  -

MCSWEENEY, Kristen Renee, Laura Kate GADANEC, Peter KUBATKA, Martin CAPRNA, Ludovit GASPAR, Robert PROSECKÝ, Delian DELEV, Peter KRUŽLIAK, Vasso APOSTOLOPOULOS a Anthony ZULLI. Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study. \textit{MOLECULAR AND CELLULAR BIOCHEMISTRY}. NETHERLANDS: SPRINGER, 2023, roč.~478, č.~12, s.~2907-2916. ISSN~0300-8177. Dostupné z: https://dx.doi.org/10.1007/s11010-023-04706-2.

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