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@article{2370981,
author = {McSweeney, Kristen Renee and Gadanec, Laura Kate and Kubatka, Peter and Caprna, Martin and Gaspar, Ludovit and Prosecký, Robert and Delev, Delian and Kružliak, Peter and Apostolopoulos, Vasso and Zulli, Anthony},
article_location = {NETHERLANDS},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s11010-023-04706-2},
keywords = {Angiotensin II; Angiotensin type 1 receptor; Angiotensin type 2 receptor; Cisplatin; Contraction; Renin angiotensin system},
language = {eng},
issn = {0300-8177},
journal = {MOLECULAR AND CELLULAR BIOCHEMISTRY},
title = {Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study},
url = {https://link.springer.com/article/10.1007/s11010-023-04706-2},
volume = {478},
year = {2023}
}
TY - JOUR
ID - 2370981
AU - McSweeney, Kristen Renee - Gadanec, Laura Kate - Kubatka, Peter - Caprna, Martin - Gaspar, Ludovit - Prosecký, Robert - Delev, Delian - Kružliak, Peter - Apostolopoulos, Vasso - Zulli, Anthony
PY - 2023
TI - Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study
JF - MOLECULAR AND CELLULAR BIOCHEMISTRY
VL - 478
IS - 12
SP - 2907-2916
EP - 2907-2916
PB - SPRINGER
SN - 03008177
KW - Angiotensin II
KW - Angiotensin type 1 receptor
KW - Angiotensin type 2 receptor
KW - Cisplatin
KW - Contraction
KW - Renin angiotensin system
UR - https://link.springer.com/article/10.1007/s11010-023-04706-2
N2 - The renin angiotensin system is a key regulator of blood pressure homeostasis. Angiotensin type 1 (AT1R) and 2 receptors (AT2R) have been investigated as targets for cisplatin-induced acute kidney injury; however, their therapeutic potential remains inconclusive. This pilot study aimed to determined the effect that acute cisplatin treatment had on angiotensin II (AngII)-induced contraction in blood vessels and expression profiles of AT1R and AT2R in mouse arteries and kidneys. Male C57BL/6 mice at 18 week of age (n = 8) were treated with vehicle or bolus dose of cisplatin (12.5 mg/kg). Thoracic aorta (TA), adnominal aorta (AA), brachiocephalic arteries (BC), iliac arteries (IL) and kidneys were collected for isometric tension and immunohistochemistry analysis. Cisplatin treatment reduced IL contraction to AngII at all doses (p < 0.01, p < 0.001, p < 0.0001); however, AngII did not induce contraction in TA, AA or BC in either treatment group. Following cisplatin treatment, AT1R expression was significantly upregulated in the media of TA (p < 0.0001) and AA (p < 0.0001), and in the endothelium (p < 0.05) media (p < 0.0001) and adventitia (p < 0.01) of IL. Cisplatin treatment significantly reduced AT2R expression in the endothelium (p < 0.05) and media (p < 0.05) of TA. In renal tubules, both AT1R (p < 0.01) and AT2R (p < 0.05) were increased following cisplatin treatment. Herein, we report that cisplatin reduces AngII-mediated contraction in IL and may be explained by an absence of normal counterregulatory expression of AT1R and AT2R, indicating other factors are involved.
ER -
MCSWEENEY, Kristen Renee, Laura Kate GADANEC, Peter KUBATKA, Martin CAPRNA, Ludovit GASPAR, Robert PROSECKÝ, Delian DELEV, Peter KRUŽLIAK, Vasso APOSTOLOPOULOS and Anthony ZULLI. Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study. \textit{MOLECULAR AND CELLULAR BIOCHEMISTRY}. NETHERLANDS: SPRINGER, 2023, vol.~478, No~12, p.~2907-2916. ISSN~0300-8177. Available from: https://dx.doi.org/10.1007/s11010-023-04706-2.
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