Bariatric surgery and its impact on depressive symptoms,
cognition, brain and inflammation

J 2023

Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation

KOTAČKOVÁ, Lenka, Radek MAREČEK, Andrei MOURAVIEV, Ariana TANG, Milan BRÁZDIL et. al.

Basic information

Original name

Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation

Authors

KOTAČKOVÁ, Lenka (703 Slovakia, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Andrei MOURAVIEV, Ariana TANG, Milan BRÁZDIL (203 Czech Republic, belonging to the institution), Michal CIERNY, Tomas PAUS, Zdenka PAUSOVA and Klára MAREČKOVÁ (203 Czech Republic, guarantor)

Edition

FRONTIERS IN ENDOCRINOLOGY, SWITZERLAND, FRONTIERS MEDIA SA, 2023, 1664-2392

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.200 in 2022

RIV identification code

RIV/00216224:14740/23:00133482

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3389/fendo.2023.1171244

UT WoS

001029987300001

Keywords in English

bariatric surgery; obesity; visceral fat; cortical thickness; depression; cognition; inflammation; longitudinal

Abstract

V originále

BackgroundObesity has been associated with depressive symptoms and impaired cognition, but the mechanisms underlying these relationships are not well understood. It is also not clear whether reducing adiposity reverses these behavioral outcomes. The current study tested the impact of bariatric surgery on depressive symptoms, cognition, and the brain; using a mediation model, we also examined whether the relationship between changes in adiposity after the surgery and those in regional thickness of the cerebral cortex are mediated by changes in low-grade inflammation (as indexed by C-reactive protein; CRP). MethodsA total of 18 bariatric patients completed 3 visits, including one baseline before the surgery and two post-surgery measurements acquired at 6- and 12-months post-surgery. Each visit consisted of a collection of fasting blood sample, magnetic resonance imaging of the brain and abdomen, and assessment of depressive symptoms and cognition. ResultsAfter surgery, we observed reductions of both visceral fat (p< 0.001) and subcutaneous fat (p< 0.001), less depressive symptoms (p< 0.001), improved verbal reasoning (p< 0.001), and reduced CRP (p< 0.001). Mediation analyses revealed that the relationships between the surgery-related changes in visceral fat and cortical thickness in depression-related regions are mediated by changes in CRP (ab=-.027, SE=.012, 95% CI [-.054, -,006]). ConclusionThese findings suggest that some of the beneficial effects of bariatric surgery on brain function and structure are due to a reduction of adiposity-related low-grade systemic inflammation.

Links

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

KOTAČKOVÁ, Lenka, Radek MAREČEK, Andrei MOURAVIEV, Ariana TANG, Milan BRÁZDIL, Michal CIERNY, Tomas PAUS, Zdenka PAUSOVA and Klára MAREČKOVÁ. Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation. FRONTIERS IN ENDOCRINOLOGY. SWITZERLAND: FRONTIERS MEDIA SA, 2023, vol. 14, July, p. 1-10. ISSN 1664-2392. Available from: https://dx.doi.org/10.3389/fendo.2023.1171244.

@article{2371157,
   author = {Kotačková, Lenka and Mareček, Radek and Mouraviev, Andrei and Tang, Ariana and Brázdil, Milan and Cierny, Michal and Paus, Tomas and Pausova, Zdenka and Marečková, Klára},
   article_location = {SWITZERLAND},
   article_number = {July},
   doi = {http://dx.doi.org/10.3389/fendo.2023.1171244},
   keywords = {bariatric surgery; obesity; visceral fat; cortical thickness; depression; cognition; inflammation; longitudinal},
   language = {eng},
   issn = {1664-2392},
   journal = {FRONTIERS IN ENDOCRINOLOGY},
   title = {Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation},
   url = {https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1171244/full},
   volume = {14},
   year = {2023}
}

TY  - JOUR
ID  - 2371157
AU  - Kotačková, Lenka - Mareček, Radek - Mouraviev, Andrei - Tang, Ariana - Brázdil, Milan - Cierny, Michal - Paus, Tomas - Pausova, Zdenka - Marečková, Klára
PY  - 2023
TI  - Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation
JF  - FRONTIERS IN ENDOCRINOLOGY
VL  - 14
IS  - July
SP  - 1-10
EP  - 1-10
PB  - FRONTIERS MEDIA SA
SN  - 16642392
KW  - bariatric surgery
KW  - obesity
KW  - visceral fat
KW  - cortical thickness
KW  - depression
KW  - cognition
KW  - inflammation
KW  - longitudinal
UR  - https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1171244/full
N2  - BackgroundObesity has been associated with depressive symptoms and impaired cognition, but the mechanisms underlying these relationships are not well understood. It is also not clear whether reducing adiposity reverses these behavioral outcomes. The current study tested the impact of bariatric surgery on depressive symptoms, cognition, and the brain; using a mediation model, we also examined whether the relationship between changes in adiposity after the surgery and those in regional thickness of the cerebral cortex are mediated by changes in low-grade inflammation (as indexed by C-reactive protein; CRP). MethodsA total of 18 bariatric patients completed 3 visits, including one baseline before the surgery and two post-surgery measurements acquired at 6- and 12-months post-surgery. Each visit consisted of a collection of fasting blood sample, magnetic resonance imaging of the brain and abdomen, and assessment of depressive symptoms and cognition. ResultsAfter surgery, we observed reductions of both visceral fat (p< 0.001) and subcutaneous fat (p< 0.001), less depressive symptoms (p< 0.001), improved verbal reasoning (p< 0.001), and reduced CRP (p< 0.001). Mediation analyses revealed that the relationships between the surgery-related changes in visceral fat and cortical thickness in depression-related regions are mediated by changes in CRP (ab=-.027, SE=.012, 95% CI [-.054, -,006]). ConclusionThese findings suggest that some of the beneficial effects of bariatric surgery on brain function and structure are due to a reduction of adiposity-related low-grade systemic inflammation.
ER  -

KOTAČKOVÁ, Lenka, Radek MAREČEK, Andrei MOURAVIEV, Ariana TANG, Milan BRÁZDIL, Michal CIERNY, Tomas PAUS, Zdenka PAUSOVA and Klára MAREČKOVÁ. Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation. \textit{FRONTIERS IN ENDOCRINOLOGY}. SWITZERLAND: FRONTIERS MEDIA SA, 2023, vol.~14, July, p.~1-10. ISSN~1664-2392. Available from: https://dx.doi.org/10.3389/fendo.2023.1171244.

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