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@article{2371788, author = {Kováč, Daniel and Mekyska, Jiří and Aharonson, Vered and Harar, Pavol and Galaz, Zoltan and Rapcsak, Steven and OrozcoandArroyave, Juan Rafael and Brabenec, Luboš and Rektorová, Irena}, article_location = {OXFORD}, article_number = {B}, doi = {http://dx.doi.org/10.1016/j.bspc.2023.105667}, keywords = {Hypokinetic dysarthria; Parkinson's disease; Multilingual study; Acoustic speech features; Statistical analysis; Machine learning}, language = {eng}, issn = {1746-8094}, journal = {Biomedical Signal Processing and Control}, title = {Exploring digital speech biomarkers of hypokinetic dysarthria in a multilingual cohort}, url = {https://www.sciencedirect.com/science/article/pii/S174680942301100X?via%3Dihub}, volume = {88}, year = {2024} }
TY - JOUR ID - 2371788 AU - Kováč, Daniel - Mekyska, Jiří - Aharonson, Vered - Harar, Pavol - Galaz, Zoltan - Rapcsak, Steven - Orozco-Arroyave, Juan Rafael - Brabenec, Luboš - Rektorová, Irena PY - 2024 TI - Exploring digital speech biomarkers of hypokinetic dysarthria in a multilingual cohort JF - Biomedical Signal Processing and Control VL - 88 IS - B SP - 1-11 EP - 1-11 PB - ELSEVIER SCI LTD SN - 17468094 KW - Hypokinetic dysarthria KW - Parkinson's disease KW - Multilingual study KW - Acoustic speech features KW - Statistical analysis KW - Machine learning UR - https://www.sciencedirect.com/science/article/pii/S174680942301100X?via%3Dihub N2 - Hypokinetic dysarthria, a motor speech disorder characterized by reduced movement and control in the speech -related muscles, is mostly associated with Parkinson's disease. Acoustic speech features thus offer the potential for early digital biomarkers to diagnose and monitor the progression of this disease. However, the influence of language on the successful classification of healthy and dysarthric speech remains crucial. This paper explores the analysis of acoustic speech features, both established and newly proposed, in a multilingual context to support the diagnosis of PD. The study aims to identify language-independent and highly discriminative digital speech biomarkers using statistical analysis and machine learning techniques. The study analyzes thirty-three acoustic features extracted from Czech, American, Israeli, Columbian, and Italian PD patients, as well as healthy controls. The analysis employs correlation and statistical tests, descriptive statistics, and the XGBoost classifier. Feature importances and Shapley values are used to provide explanations for the classification results. The study reveals that the most discriminative features, with reduced language dependence, are those measuring the prominence of the second formant, monopitch, and the frequency of pauses during text reading. Classification accuracies range from 67% to 85%, depending on the language. This paper introduces the concept of language robustness as a desirable quality in digital speech biomarkers, ensuring consistent behaviour across languages. By leveraging this concept and employing additional metrics, the study proposes several language-independent digital speech biomarkers with high discrimination power for diagnosing PD. ER -
KOVÁČ, Daniel, Jiří MEKYSKA, Vered AHARONSON, Pavol HARAR, Zoltan GALAZ, Steven RAPCSAK, Juan Rafael OROZCO-ARROYAVE, Luboš BRABENEC a Irena REKTOROVÁ. Exploring digital speech biomarkers of hypokinetic dysarthria in a multilingual cohort. \textit{Biomedical Signal Processing and Control}. OXFORD: ELSEVIER SCI LTD, 2024, roč.~88, B, s.~1-11. ISSN~1746-8094. Dostupné z: https://dx.doi.org/10.1016/j.bspc.2023.105667.
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