PATERNOGA, Helge, Caillan CROWE-MCAULIFFE, Lars V BOCK, Timm O KOLLER, Martino MORICI, Bertrand BECKERT, Alexander G MYASNIKOV, Helmut GRUBMUELLER, Jiří NOVÁČEK and Daniel N WILSON. Structural conservation of antibiotic interaction with ribosomes. NATURE STRUCTURAL & MOLECULAR BIOLOGY. NEW YORK: NATURE PUBLISHING GROUP, 2023, vol. 30, No 9, p. 1380-1414. ISSN 1545-9993. Available from: https://dx.doi.org/10.1038/s41594-023-01047-y.
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Basic information
Original name Structural conservation of antibiotic interaction with ribosomes
Authors PATERNOGA, Helge, Caillan CROWE-MCAULIFFE, Lars V BOCK, Timm O KOLLER, Martino MORICI, Bertrand BECKERT, Alexander G MYASNIKOV, Helmut GRUBMUELLER, Jiří NOVÁČEK (203 Czech Republic, belonging to the institution) and Daniel N WILSON (guarantor).
Edition NATURE STRUCTURAL & MOLECULAR BIOLOGY, NEW YORK, NATURE PUBLISHING GROUP, 2023, 1545-9993.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 16.800 in 2022
RIV identification code RIV/00216224:14740/23:00133510
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1038/s41594-023-01047-y
UT WoS 001043691200001
Keywords in English ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies
Tags CF CRYO, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Dubská, učo 77638. Changed: 7/3/2024 09:57.
Abstract
Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.
Links
EF18_046/0015974, research and development projectName: Modernizace České infrastruktury pro integrativní strukturní biologii
LM2023042, research and development projectName: Česká infrastruktura pro integrativní strukturní biologii
Investor: Ministry of Education, Youth and Sports of the CR, CIISB - Czech Infrastructure for Integrative Structural Biology
871037, interní kód MUName: iNEXT-Discovery: Infrastructure for transnational access and discovery in integrated structural biology (Acronym: iNEXT- Discovery)
Investor: European Union, RI Research Infrastructures (Excellent Science)
90242, large research infrastructuresName: CIISB III
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