Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering

ČIMBOROVÁ, Katarína, Vendula PELKOVÁ, Hana KOTASOVÁ, Veronika SEDLÁKOVÁ a Aleš HAMPL. Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering. In BIOCEV Regeneration III, 2023. 2023.

Základní údaje

• Originální název: Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering
• Název anglicky: Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering
• Autoři: ČIMBOROVÁ, Katarína, Vendula PELKOVÁ, Hana KOTASOVÁ, Veronika SEDLÁKOVÁ a Aleš HAMPL.
• Vydání: BIOCEV Regeneration III, 2023, 2023.

Další údaje

• Typ výsledku: Konferenční abstrakt
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Příznaky: Mezinárodní význam

Anotace

The structural and physiological features of the lungs make the success of engineering an artificial lung model in vitro a challenge. From a slew of approaches utilized in pulmonary tissue engineering, this work focuses on the detergent-based decellularization method for obtaining a well-preserved human, pig, and mouse lung tissue scaffold. Decellularization is a method based on removing cells and the entire genetic material from a preexisting organ or tissue while preserving the composition, 3D microarchitecture, and biochemical and biophysical properties of the pulmonary tissue. These scaffolds may serve as in vitro near-to-native 3D pulmonary models, hydrogels, or bio-inks for 3D printing which hold a valuable opportunity for disease modeling, drug testing, and regeneration.