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@article{2374284, author = {Luca, De Sabato and Ianiro, Giovanni and Alborali, Giovanni L and Kroneman, Annelies and Grierson, Sylvia S and KrumovaandValcheva, Gergana Lyubomirova and Hakzeandvan, der Honing Renate W and Johne, Reimar and Koláčková, Ivana and Kozyra, Iwona and Gyurova, Eva and Pavoni, Enrico and Reisp, Katharina and Sassu, Elena Lucia and SchillingandLoeffler, Katja and Smith, Richard Piers and Vasickova, Petra and Zmudzki, Jacek and Rzezutka, Artur and Ilaria, Di Bartolo}, article_location = {Hoboken}, article_number = {December 2023}, doi = {http://dx.doi.org/10.1155/2023/2806835}, keywords = {Hepatitis E Virus}, language = {eng}, issn = {1865-1674}, journal = {Transboundary and Emerging Diseases}, title = {Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022}, url = {https://www.hindawi.com/journals/tbed/2023/2806835/}, volume = {2023}, year = {2023} }
TY - JOUR ID - 2374284 AU - Luca, De Sabato - Ianiro, Giovanni - Alborali, Giovanni L - Kroneman, Annelies - Grierson, Sylvia S - Krumova-Valcheva, Gergana Lyubomirova - Hakze-van, der Honing Renate W - Johne, Reimar - Koláčková, Ivana - Kozyra, Iwona - Gyurova, Eva - Pavoni, Enrico - Reisp, Katharina - Sassu, Elena Lucia - Schilling-Loeffler, Katja - Smith, Richard Piers - Vasickova, Petra - Zmudzki, Jacek - Rzezutka, Artur - Ilaria, Di Bartolo PY - 2023 TI - Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022 JF - Transboundary and Emerging Diseases VL - 2023 IS - December 2023 SP - 1-12 EP - 1-12 PB - Wiley-Blackwell SN - 18651674 KW - Hepatitis E Virus UR - https://www.hindawi.com/journals/tbed/2023/2806835/ N2 - In high-income countries, the hepatitis E virus (HEV) is considered an emerging threat causing autochthonous acute hepatitis in humans, with an increased number of reported cases over the last 10 years and related increased burden of chronic hepatitis in immunocompromised and transplant patients. Pigs are the main reservoir of the HEV-3 genotype, which is the most common in Europe, and can be transmitted to humans through the consumption of raw and undercooked pork products. Extensive sequencing revealed the existence of several HEV-3 subtypes in both humans and pigs, confirming a broad heterogeneity of the virus, with some subtypes, such as 3e, 3f, and 3c, which are predominant in Europe. In this study, 291 HEV sequences were obtained from pig feces sampled in more than 74 farms located in Austria, Bulgaria, Czech Republic, Germany, Italy, Poland, the United Kingdom, as well as an unknown number of farms in Netherlands. Of the 99 nonidentical sequences (99/291), 90 were assigned to seven established HEV-3 subtypes: 3a, 3c, 3e, 3f, 3g (here named 3g-like), 3i, and 3l (named 3l-like), already described in Europe, while nine sequences of HEV-3 could not be assigned to any existing subtype (here named 3 *). The 3e subtype was the most common, detected in six out of eight countries, followed by 3f and 3c, which were also present in several countries; 3g-like, 3i, and 3l-like subtypes showed only a limited circulation. The distribution of frequently (3e, 3f, and 3c) and rarely (3g-like, 3i, and 3l-like) detected HEV-3 subtypes in pigs was correlated with their detection rates in human patients in Europe. The results from this study confirm the wide circulation of several HEV-3 strains in European pigs and confirm that sequencing is needed to monitor the different strains and to identify possible zoonotic transmission paths. ER -
LUCA, De Sabato, Giovanni IANIRO, Giovanni L ALBORALI, Annelies KRONEMAN, Sylvia S GRIERSON, Gergana Lyubomirova KRUMOVA-VALCHEVA, der Honing Renate W HAKZE-VAN, Reimar JOHNE, Ivana KOLÁČKOVÁ, Iwona KOZYRA, Eva GYUROVA, Enrico PAVONI, Katharina REISP, Elena Lucia SASSU, Katja SCHILLING-LOEFFLER, Richard Piers SMITH, Petra VASICKOVA, Jacek ZMUDZKI, Artur RZEZUTKA a Di Bartolo ILARIA. Molecular Characterization and Phylogenetic Analysis of Hepatitis E Virus (HEV) Strains from Pigs Farmed in Eight European Countries between 2020 and 2022. \textit{Transboundary and Emerging Diseases}. Hoboken: Wiley-Blackwell, 2023, roč.~2023, December 2023, s.~1-12. ISSN~1865-1674. Dostupné z: https://dx.doi.org/10.1155/2023/2806835.
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