Songbirds avoid the oxidative stress costs of high blood
glucose levels: a comparative study

J 2024

Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ, Tereza KAUZÁLOVÁ, Ádám Z. LENDVAI et. al.

Základní údaje

Originální název

Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study

Autoři

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ (203 Česká republika, domácí), Tereza KAUZÁLOVÁ (203 Česká republika), Ádám Z. LENDVAI, Laura I. PATRAS, Janka PÉNZES, Péter L. PAP, Tomáš ALBRECHT (203 Česká republika) a Oldřich TOMÁŠEK (203 Česká republika, domácí)

Vydání

The Journal of Experimental Biology, Company of Biologists Ltd, 2024, 0022-0949

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10615 Ornithology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL URL

Impakt faktor

Impact factor: 2.800 v roce 2022

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1242/jeb.246848

UT WoS

001214515700010

Klíčová slova anglicky

Antioxidants; Glucose; Hyperglycaemia; Lipid peroxidation; Phylogenetic comparison; Physiological ecology

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 5. 2024 11:19, Mgr. Marie Šípková, DiS.

Anotace

V originále

Chronically high blood glucose levels (hyperglycaemia) can compromise healthy ageing and lifespan at the individual level. Elevated oxidative stress can play a central role in hyperglycaemia-induced pathologies. Nevertheless, the lifespan of birds shows no species-level association with blood glucose. This suggests that the potential pathologies of high blood glucose levels can be avoided by adaptations in oxidative physiology at the macroevolutionary scale. However, this hypothesis remains unexplored. Here, we examined this hypothesis using comparative analyses controlled for phylogeny, allometry and fecundity based on data from 51 songbird species (681 individuals with blood glucose data and 1021 individuals with oxidative state data). We measured blood glucose at baseline and after stress stimulus and computed glucose stress reactivity as the magnitude of change between the two time points. We also measured three parameters of non-enzymatic antioxidants (uric acid, total antioxidants and glutathione) and a marker of oxidative lipid damage (malondialdehyde). We found no clear evidence for blood glucose concentration being correlated with either antioxidant or lipid damage levels at the macroevolutionary scale, as opposed to the hypothesis postulating that high blood glucose levels entail oxidative costs. The only exception was the moderate evidence for species with a stronger stress-induced increase in blood glucose concentration evolving moderately lower investment into antioxidant defence (uric acid and glutathione). Neither baseline nor stress-induced glucose levels were associated with oxidative physiology. Our findings support the hypothesis that birds evolved adaptations preventing the (glyc)oxidative costs of high blood glucose observed at the within-species level. Such adaptations may explain the decoupled evolution of glycaemia and lifespan in birds and possibly the paradoxical combination of long lifespan and high blood glucose levels relative to mammals.

Návaznosti

GA21-22160S, projekt VaV

Název: Diverzita a fyziologické mechanizmy stárnutí v populaci volně žijícího pěvce

Investor: Grantová agentura ČR, Diverzita a fyziologické mechanizmy stárnutí v populaci volně žijícího pěvce

Citovat

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ, Tereza KAUZÁLOVÁ, Ádám Z. LENDVAI, Laura I. PATRAS, Janka PÉNZES, Péter L. PAP, Tomáš ALBRECHT a Oldřich TOMÁŠEK. Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study. The Journal of Experimental Biology. Company of Biologists Ltd, 2024, roč. 227, č. 1, s. jeb246848, 8 s. ISSN 0022-0949. Dostupné z: https://dx.doi.org/10.1242/jeb.246848.

@article{2374390,
   author = {Vágási, Csongor I. and Vincze, Orsolya and Kotasová Adámková, Marie and Kauzálová, Tereza and Lendvai, Ádám Z. and Patras, Laura I. and Pénzes, Janka and Pap, Péter L. and Albrecht, Tomáš and Tomášek, Oldřich},
   article_number = {1},
   doi = {http://dx.doi.org/10.1242/jeb.246848},
   keywords = {Antioxidants; Glucose; Hyperglycaemia; Lipid peroxidation; Phylogenetic comparison; Physiological ecology},
   language = {eng},
   issn = {0022-0949},
   journal = {The Journal of Experimental Biology},
   title = {Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study},
   url = {https://journals.biologists.com/jeb/article-abstract/227/1/jeb246848/340680/Songbirds-avoid-the-oxidative-stress-costs-of-high?redirectedFrom=fulltext},
   volume = {227},
   year = {2024}
}

TY  - JOUR
ID  - 2374390
AU  - Vágási, Csongor I. - Vincze, Orsolya - Kotasová Adámková, Marie - Kauzálová, Tereza - Lendvai, Ádám Z. - Patras, Laura I. - Pénzes, Janka - Pap, Péter L. - Albrecht, Tomáš - Tomášek, Oldřich
PY  - 2024
TI  - Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study
JF  - The Journal of Experimental Biology
VL  - 227
IS  - 1
SP  - jeb246848
EP  - jeb246848
PB  - Company of Biologists Ltd
SN  - 00220949
KW  - Antioxidants
KW  - Glucose
KW  - Hyperglycaemia
KW  - Lipid peroxidation
KW  - Phylogenetic comparison
KW  - Physiological ecology
UR  - https://journals.biologists.com/jeb/article-abstract/227/1/jeb246848/340680/Songbirds-avoid-the-oxidative-stress-costs-of-high?redirectedFrom=fulltext
N2  - Chronically high blood glucose levels (hyperglycaemia) can compromise healthy ageing and lifespan at the individual level. Elevated oxidative stress can play a central role in hyperglycaemia-induced pathologies. Nevertheless, the lifespan of birds shows no species-level association with blood glucose. This suggests that the potential pathologies of high blood glucose levels can be avoided by adaptations in oxidative physiology at the macroevolutionary scale. However, this hypothesis remains unexplored. Here, we examined this hypothesis using comparative analyses controlled for phylogeny, allometry and fecundity based on data from 51 songbird species (681 individuals with blood glucose data and 1021 individuals with oxidative state data). We measured blood glucose at baseline and after stress stimulus and computed glucose stress reactivity as the magnitude of change between the two time points. We also measured three parameters of non-enzymatic antioxidants (uric acid, total antioxidants and glutathione) and a marker of oxidative lipid damage (malondialdehyde). We found no clear evidence for blood glucose concentration being correlated with either antioxidant or lipid damage levels at the macroevolutionary scale, as opposed to the hypothesis postulating that high blood glucose levels entail oxidative costs. The only exception was the moderate evidence for species with a stronger stress-induced increase in blood glucose concentration evolving moderately lower investment into antioxidant defence (uric acid and glutathione). Neither baseline nor stress-induced glucose levels were associated with oxidative physiology. Our findings support the hypothesis that birds evolved adaptations preventing the (glyc)oxidative costs of high blood glucose observed at the within-species level. Such adaptations may explain the decoupled evolution of glycaemia and lifespan in birds and possibly the paradoxical combination of long lifespan and high blood glucose levels relative to mammals.
ER  -

VÁGÁSI, Csongor I., Orsolya VINCZE, Marie KOTASOVÁ ADÁMKOVÁ, Tereza KAUZÁLOVÁ, Ádám Z. LENDVAI, Laura I. PATRAS, Janka PÉNZES, Péter L. PAP, Tomáš ALBRECHT a Oldřich TOMÁŠEK. Songbirds avoid the oxidative stress costs of high blood glucose levels: a comparative study. \textit{The Journal of Experimental Biology}. Company of Biologists Ltd, 2024, roč.~227, č.~1, s.~jeb246848, 8 s. ISSN~0022-0949. Dostupné z: https://dx.doi.org/10.1242/jeb.246848.

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