| LANGOVA, Veronika, Petra HORKA, Jan HUBENY, Tomas NOVAK, Karel VALES, Petr ADAMEK, Katerina HOLUBOVA and Jiri HORACEK. Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish. Journal of Neuroscience Research. HOBOKEN: WILEY, 2023, vol. 101, No 7, p. 1098-1106. ISSN 0360-4012. Available from: https://dx.doi.org/10.1002/jnr.25186. |
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@article{2375817,
author = {Langova, Veronika and Horka, Petra and Hubeny, Jan and Novak, Tomas and Vales, Karel and Adamek, Petr and Holubova, Katerina and Horacek, Jiri},
article_location = {HOBOKEN},
article_number = {7},
doi = {http://dx.doi.org/10.1002/jnr.25186},
keywords = {electrolocation; Gnathonemus petersii; positive symptoms; schizophrenia model; weakly electric fish},
language = {eng},
issn = {0360-4012},
journal = {Journal of Neuroscience Research},
title = {Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25186},
volume = {101},
year = {2023}
}
TY - JOUR
ID - 2375817
AU - Langova, Veronika - Horka, Petra - Hubeny, Jan - Novak, Tomas - Vales, Karel - Adamek, Petr - Holubova, Katerina - Horacek, Jiri
PY - 2023
TI - Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish
JF - Journal of Neuroscience Research
VL - 101
IS - 7
SP - 1098-1106
EP - 1098-1106
PB - WILEY
SN - 03604012
KW - electrolocation
KW - Gnathonemus petersii
KW - positive symptoms
KW - schizophrenia model
KW - weakly electric fish
UR - https://onlinelibrary.wiley.com/doi/epdf/10.1002/jnr.25186
N2 - The present study aimed to examine a weakly electric fish Gnathonemus petersii (G. petersii) as a candidate model organism of glutamatergic theory of schizophrenia. The idea of G. petersii elevating the modeling of schizophrenia symptoms is based on the fish's electrolocation and electrocommunication abilities. Fish were exposed to the NMDA antagonist ketamine in two distinct series differing in the dose of ketamine. The main finding revealed ketamine-induced disruption of the relationship between electric signaling and behavior indicating impairment of fish navigation. Moreover, lower doses of ketamine significantly increased locomotion and erratic movement and higher doses of ketamine reduced the number of electric organ discharges indicating successful induction of positive schizophrenia-like symptoms and disruption of fish navigation. Additionally, a low dose of haloperidol was used to test the normalization of the positive symptoms to suggest a predictive validity of the model. However, although successfully induced, positive symptoms were not normalized using the low dose of haloperidol; hence, more doses of the typical antipsychotic haloperidol and probably also of a representative of atypical antipsychotic drugs need to be examined to confirm the predictive validity of the model.
ER -
LANGOVA, Veronika, Petra HORKA, Jan HUBENY, Tomas NOVAK, Karel VALES, Petr ADAMEK, Katerina HOLUBOVA and Jiri HORACEK. Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish. \textit{Journal of Neuroscience Research}. HOBOKEN: WILEY, 2023, vol.~101, No~7, p.~1098-1106. ISSN~0360-4012. Available from: https://dx.doi.org/10.1002/jnr.25186.
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