2023
Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols
HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY, Veronika ANDRASHKO et. al.Základní údaje
Originální název
Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols
Autoři
HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY a Veronika ANDRASHKO
Vydání
Neuroscience Letters, CLARE, Elsevier, 2023, 0304-3940
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30230 Other clinical medicine subjects
Stát vydavatele
Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 2.500 v roce 2022
Kód RIV
RIV/00216224:90249/23:00133576
Organizační jednotka
CZECRIN IV
UT WoS
000963146600001
Klíčová slova česky
Ketamine; Postoperative delirium; Anesthesia; Neuroprotective; Neuroplastic; Benzodiazepines; Pharmacological interaction
Klíčová slova anglicky
Ketamine; Postoperative delirium; Anesthesia; Neuroprotective; Neuroplastic; Benzodiazepines; Pharmacological interaction
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 11. 4. 2024 23:26, Mgr. Michal Petr
Anotace
V originále
Ketamine exerts anti-inflammatory, neuroprotective and neuroplastic activity, therefore it may counteract the neurotoxic processes underlying postoperative delirium. However, the majority of studies in this field failed. We identified several pharmacological reasons why these studies may have failed, together with suggestions of how to remediate them. Among them, the interaction with intravenous general anesthetics exerting the opposite effect on GABA interneurons than ketamine may be of principal importance. We suggest biomarkers which may elucidate the influence of this interaction on the different steps of neuroplastic pathways. We hypothesize that administering ketamine before or after general anesthesia could both prevent the interactions and strengthen the effect of ketamine by timing surgery within the climax of ketamine-induced neuroplastic changes or by stabilizing AMPA receptors. It is vital to deal with these questions because the protocols of ongoing studies are based again on the administration of ketamine during general anesthesia (the major identified pitfall).
Návaznosti
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