J 2023

Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols

HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY, Veronika ANDRASHKO et. al.

Základní údaje

Originální název

Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols

Autoři

HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY a Veronika ANDRASHKO

Vydání

Neuroscience Letters, CLARE, Elsevier, 2023, 0304-3940

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 2.500 v roce 2022

Kód RIV

RIV/00216224:90249/23:00133576

Organizační jednotka

CZECRIN IV

UT WoS

000963146600001

Klíčová slova česky

Ketamine; Postoperative delirium; Anesthesia; Neuroprotective; Neuroplastic; Benzodiazepines; Pharmacological interaction

Klíčová slova anglicky

Ketamine; Postoperative delirium; Anesthesia; Neuroprotective; Neuroplastic; Benzodiazepines; Pharmacological interaction

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 11. 4. 2024 23:26, Mgr. Michal Petr

Anotace

V originále

Ketamine exerts anti-inflammatory, neuroprotective and neuroplastic activity, therefore it may counteract the neurotoxic processes underlying postoperative delirium. However, the majority of studies in this field failed. We identified several pharmacological reasons why these studies may have failed, together with suggestions of how to remediate them. Among them, the interaction with intravenous general anesthetics exerting the opposite effect on GABA interneurons than ketamine may be of principal importance. We suggest biomarkers which may elucidate the influence of this interaction on the different steps of neuroplastic pathways. We hypothesize that administering ketamine before or after general anesthesia could both prevent the interactions and strengthen the effect of ketamine by timing surgery within the climax of ketamine-induced neuroplastic changes or by stabilizing AMPA receptors. It is vital to deal with these questions because the protocols of ongoing studies are based again on the administration of ketamine during general anesthesia (the major identified pitfall).

Návaznosti

90249, velká výzkumná infrastruktura
Název: CZECRIN IV