| HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY and Veronika ANDRASHKO. Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols. Neuroscience Letters. CLARE: Elsevier, 2023, vol. 798, February 20213, p. 1-4. ISSN 0304-3940. Available from: https://dx.doi.org/10.1016/j.neulet.2023.137095. |
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@article{2375839,
author = {Horacek, Jiri and Janda, Robert and Görnerova, Natalie and Jajcay, Lucia and Andrashko, Veronika},
article_location = {CLARE},
article_number = {February 20213},
doi = {http://dx.doi.org/10.1016/j.neulet.2023.137095},
keywords = {Ketamine; Postoperative delirium; Anesthesia; Neuroprotective; Neuroplastic; Benzodiazepines; Pharmacological interaction},
language = {eng},
issn = {0304-3940},
journal = {Neuroscience Letters},
title = {Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols},
url = {https://www.sciencedirect.com/science/article/pii/S0304394023000496?via%3Dihub},
volume = {798},
year = {2023}
}
TY - JOUR
ID - 2375839
AU - Horacek, Jiri - Janda, Robert - Görnerova, Natalie - Jajcay, Lucia - Andrashko, Veronika
PY - 2023
TI - Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols
JF - Neuroscience Letters
VL - 798
IS - February 20213
SP - 1-4
EP - 1-4
PB - Elsevier
SN - 03043940
KW - Ketamine
KW - Postoperative delirium
KW - Anesthesia
KW - Neuroprotective
KW - Neuroplastic
KW - Benzodiazepines
KW - Pharmacological interaction
UR - https://www.sciencedirect.com/science/article/pii/S0304394023000496?via%3Dihub
N2 - Ketamine exerts anti-inflammatory, neuroprotective and neuroplastic activity, therefore it may counteract the neurotoxic processes underlying postoperative delirium. However, the majority of studies in this field failed. We identified several pharmacological reasons why these studies may have failed, together with suggestions of how to remediate them. Among them, the interaction with intravenous general anesthetics exerting the opposite effect on GABA interneurons than ketamine may be of principal importance. We suggest biomarkers which may elucidate the influence of this interaction on the different steps of neuroplastic pathways. We hypothesize that administering ketamine before or after general anesthesia could both prevent the interactions and strengthen the effect of ketamine by timing surgery within the climax of ketamine-induced neuroplastic changes or by stabilizing AMPA receptors. It is vital to deal with these questions because the protocols of ongoing studies are based again on the administration of ketamine during general anesthesia (the major identified pitfall).
ER -
HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY and Veronika ANDRASHKO. Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols. \textit{Neuroscience Letters}. CLARE: Elsevier, 2023, vol.~798, February 20213, p.~1-4. ISSN~0304-3940. Available from: https://dx.doi.org/10.1016/j.neulet.2023.137095.
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