J 2024

Distance from main arteries influences microstructural and functional brain tissue characteristics

WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ et. al.

Základní údaje

Originální název

Distance from main arteries influences microstructural and functional brain tissue characteristics

Autoři

WEISS, Viktor (203 Česká republika, domácí), Viktória KOKOŠOVÁ (703 Slovensko, domácí), Zdenek VALENTA (203 Česká republika), Irena DOLEŽALOVÁ (203 Česká republika, domácí), Marek BALÁŽ (703 Slovensko, domácí), Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK (203 Česká republika, domácí), Igor NESTRASIL (203 Česká republika), Roman HERZIG (203 Česká republika) a Pavel FILIP (703 Slovensko, garant)

Vydání

Neuroimage, San Diego, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, 1053-8119

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 5.700 v roce 2022

Organizační jednotka

Lékařská fakulta

UT WoS

001139614000001

Klíčová slova anglicky

Quantitative MRI; Relaxometry; Diffusion weighted imaging; Resting -state functional MRI; Arterial distance

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 9. 3. 2024 14:52, Mgr. Eva Dubská

Anotace

V originále

Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1p, T2p, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1p, T2p and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings.

Návaznosti

LM2018129, projekt VaV
Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging