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@article{2377568,
author = {Yadav, Anoop Kumar and PolášekandSedláčková, Hana},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s42003-024-05855-w},
keywords = {EUKARYOTIC DNA-REPLICATION; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE; MCM PROTEINS; S-PHASE; NUCLEAR-LOCALIZATION; DORMANT ORIGINS; BIND CHROMATIN; EXCESS MCM2-7; HUMAN MEMBER},
language = {eng},
issn = {2399-3642},
journal = {Communications Biology},
title = {Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity},
url = {https://www.nature.com/articles/s42003-024-05855-w},
volume = {7},
year = {2024}
}
TY - JOUR
ID - 2377568
AU - Yadav, Anoop Kumar - Polášek-Sedláčková, Hana
PY - 2024
TI - Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
JF - Communications Biology
VL - 7
IS - 1
SP - 1-14
EP - 1-14
PB - Nature Research
SN - 23993642
KW - EUKARYOTIC DNA-REPLICATION
KW - ORIGIN RECOGNITION COMPLEX
KW - CELL-CYCLE
KW - MCM PROTEINS
KW - S-PHASE
KW - NUCLEAR-LOCALIZATION
KW - DORMANT ORIGINS
KW - BIND CHROMATIN
KW - EXCESS MCM2-7
KW - HUMAN MEMBER
UR - https://www.nature.com/articles/s42003-024-05855-w
N2 - Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.
ER -
YADAV, Anoop Kumar a Hana POLÁŠEK-SEDLÁČKOVÁ. Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity. \textit{Communications Biology}. Nature Research, 2024, roč.~7, č.~1, s.~1-14. ISSN~2399-3642. Dostupné z: https://dx.doi.org/10.1038/s42003-024-05855-w.
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