Quantity and quality of minichromosome maintenance protein
complexes couple replication licensing to genome integrity

J 2024

Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity

YADAV, Anoop Kumar a Hana POLÁŠEK-SEDLÁČKOVÁ

Základní údaje

Originální název

Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity

Autoři

YADAV, Anoop Kumar (356 Indie, domácí) a Hana POLÁŠEK-SEDLÁČKOVÁ

Vydání

Communications Biology, Nature Research, 2024, 2399-3642

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.900 v roce 2022

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/s42003-024-05855-w

UT WoS

001159273400002

Klíčová slova anglicky

EUKARYOTIC DNA-REPLICATION; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE; MCM PROTEINS; S-PHASE; NUCLEAR-LOCALIZATION; DORMANT ORIGINS; BIND CHROMATIN; EXCESS MCM2-7; HUMAN MEMBER

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 2. 2024 14:11, Mgr. Marie Šípková, DiS.

Anotace

V originále

Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.

Citovat

YADAV, Anoop Kumar a Hana POLÁŠEK-SEDLÁČKOVÁ. Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity. Communications Biology. Nature Research, 2024, roč. 7, č. 1, s. 1-14. ISSN 2399-3642. Dostupné z: https://dx.doi.org/10.1038/s42003-024-05855-w.

@article{2377568,
   author = {Yadav, Anoop Kumar and PolášekandSedláčková, Hana},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s42003-024-05855-w},
   keywords = {EUKARYOTIC DNA-REPLICATION; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE; MCM PROTEINS; S-PHASE; NUCLEAR-LOCALIZATION; DORMANT ORIGINS; BIND CHROMATIN; EXCESS MCM2-7; HUMAN MEMBER},
   language = {eng},
   issn = {2399-3642},
   journal = {Communications Biology},
   title = {Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity},
   url = {https://www.nature.com/articles/s42003-024-05855-w},
   volume = {7},
   year = {2024}
}

TY  - JOUR
ID  - 2377568
AU  - Yadav, Anoop Kumar - Polášek-Sedláčková, Hana
PY  - 2024
TI  - Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
JF  - Communications Biology
VL  - 7
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - Nature Research
SN  - 23993642
KW  - EUKARYOTIC DNA-REPLICATION
KW  - ORIGIN RECOGNITION COMPLEX
KW  - CELL-CYCLE
KW  - MCM PROTEINS
KW  - S-PHASE
KW  - NUCLEAR-LOCALIZATION
KW  - DORMANT ORIGINS
KW  - BIND CHROMATIN
KW  - EXCESS MCM2-7
KW  - HUMAN MEMBER
UR  - https://www.nature.com/articles/s42003-024-05855-w
N2  - Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.
ER  -

YADAV, Anoop Kumar a Hana POLÁŠEK-SEDLÁČKOVÁ. Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity. \textit{Communications Biology}. Nature Research, 2024, roč.~7, č.~1, s.~1-14. ISSN~2399-3642. Dostupné z: https://dx.doi.org/10.1038/s42003-024-05855-w.

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