Oxidative stress, microparticles, and E-selectin do not depend
on HIV suppression

J 2024

Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression

HAVLÍČKOVÁ, Kateřina, Svatava SNOPKOVÁ, Miroslav POHANKA, Radek SVAČINKA, David VYDRÁŘ et. al.

Základní údaje

Originální název

Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression

Autoři

HAVLÍČKOVÁ, Kateřina, Svatava SNOPKOVÁ, Miroslav POHANKA, Radek SVAČINKA, David VYDRÁŘ, Petr HUSA, Jiřina ZAVŘELOVÁ, Filip ZLÁMAL, Lenka FABIANOVÁ, Miroslav PENKA a Petr HUSA

Vydání

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2024, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.900 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5507/bp.2024.002

UT WoS

001171815400001

Klíčová slova anglicky

oxidative stress; microparticles;E-selectin; HIV suppression

Štítky

14110212, 14110214

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 6. 2024 12:28, Mgr. Tereza Miškechová

Anotace

V originále

Background. Oxidative stress and inflammation are considered predictors of diseases associated with aging. Markers of oxidative stress, inflammation, and endothelial activation were investigated in people with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Patients and Methods. This study was conducted on 213 subjects with HIV. The control groups consisted of healthy HIV-negative adults. The level of oxidative stress was measured by assessing the production of malondialdehyde levels, which were detected by thiobarbituric acid reactive substance (TBARS) assay. The level of microparticles indicated the presence of inflammation and endothelial activation was measured by E-selectin levels. Significant differences were determined by appropriate statistical tests, depending on the distribution of variables. Relationships between continuous variables were quantified using Spearman’s rank correlation coefficient. Results. TBARS, and microparticle and E-selectin levels were significantly higher in untreated and treated subjects with HIV compared with HIV-negative controls (P<0.001). The levels of the investigated markers were not significantly different between untreated and treated patients and no significant correlation of these markers was found with CD4+ count, CD4+/CD8+ ratio, and the number of HIV-1 RNA copies. Conclusions. Elevated markers of oxidative stress, inflammatory and endothelial activation were independent of the virologic and immunologic status of people with HIV. These results support the hypothesis that residual viremia in cellular reservoirs of various tissues is a key factor related to the premature aging of the immune system and predisposition to the premature development of diseases associated with aging.

Citovat

HAVLÍČKOVÁ, Kateřina, Svatava SNOPKOVÁ, Miroslav POHANKA, Radek SVAČINKA, David VYDRÁŘ, Petr HUSA, Jiřina ZAVŘELOVÁ, Filip ZLÁMAL, Lenka FABIANOVÁ, Miroslav PENKA a Petr HUSA. Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2024, roč. 168, č. 2, s. 1-9. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2024.002.

@article{2378959,
   author = {Havlíčková, Kateřina and Snopková, Svatava and Pohanka, Miroslav and Svačinka, Radek and Vydrář, David and Husa, Petr and Zavřelová, Jiřina and Zlámal, Filip and Fabianová, Lenka and Penka, Miroslav and Husa, Petr},
   article_location = {Olomouc},
   article_number = {2},
   doi = {http://dx.doi.org/10.5507/bp.2024.002},
   keywords = {oxidative stress; microparticles;E-selectin; HIV suppression},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers, Olomouc: Palacky University},
   title = {Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3607},
   volume = {168},
   year = {2024}
}

TY  - JOUR
ID  - 2378959
AU  - Havlíčková, Kateřina - Snopková, Svatava - Pohanka, Miroslav - Svačinka, Radek - Vydrář, David - Husa, Petr - Zavřelová, Jiřina - Zlámal, Filip - Fabianová, Lenka - Penka, Miroslav - Husa, Petr
PY  - 2024
TI  - Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression
JF  - Biomedical Papers, Olomouc: Palacky University
VL  - 168
IS  - 2
SP  - 1-9
EP  - 1-9
PB  - Palacky University
SN  - 12138118
KW  - oxidative stress
KW  - microparticles;E-selectin
KW  - HIV suppression
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3607
N2  - Background. Oxidative stress and inflammation are considered predictors of diseases associated with aging. Markers of oxidative stress, inflammation, and endothelial activation were investigated in people with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Patients and Methods. This study was conducted on 213 subjects with HIV. The control groups consisted of healthy HIV-negative adults. The level of oxidative stress was measured by assessing the production of malondialdehyde levels, which were detected by thiobarbituric acid reactive substance (TBARS) assay. The level of microparticles indicated the presence of inflammation and endothelial activation was measured by E-selectin levels. Significant differences were determined by appropriate statistical tests, depending on the distribution of variables. Relationships between continuous variables were quantified using Spearman’s rank correlation coefficient. Results. TBARS, and microparticle and E-selectin levels were significantly higher in untreated and treated subjects with HIV compared with HIV-negative controls (P<0.001). The levels of the investigated markers were not significantly different between untreated and treated patients and no significant correlation of these markers was found with CD4+ count, CD4+/CD8+ ratio, and the number of HIV-1 RNA copies. Conclusions. Elevated markers of oxidative stress, inflammatory and endothelial activation were independent of the virologic and immunologic status of people with HIV. These results support the hypothesis that residual viremia in cellular reservoirs of various tissues is a key factor related to the premature aging of the immune system and predisposition to the premature development of diseases associated with aging.
ER  -

HAVLÍČKOVÁ, Kateřina, Svatava SNOPKOVÁ, Miroslav POHANKA, Radek SVAČINKA, David VYDRÁŘ, Petr HUSA, Jiřina ZAVŘELOVÁ, Filip ZLÁMAL, Lenka FABIANOVÁ, Miroslav PENKA a Petr HUSA. Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2024, roč.~168, č.~2, s.~1-9. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2024.002.

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