Pediatric neurovascular complication of SARS-CoV-2 infection: A single Center Case-Series.

MUŽLAYOVÁ, Patrícia, Klára ŠPANĚLOVÁ, Tamara SKŘÍŠOVSKÁ, Ondřej HORÁK, Jan ŠENKYŘÍK, Anna SEEHOFNEROVÁ, Lukáš HOMOLA, Jozef KLUČKA, Jan BLATNÝ, Hana OŠLEJŠKOVÁ and Pavlína DANHOFER. Pediatric neurovascular complication of SARS-CoV-2 infection: A single Center Case-Series. In 15th Congress of the European Pediatric Neurology Society (EPNS), Prague. 2023.

Basic information

• Original name: Pediatric neurovascular complication of SARS-CoV-2 infection: A single Center Case-Series.
• Authors: MUŽLAYOVÁ, Patrícia, Klára ŠPANĚLOVÁ, Tamara SKŘÍŠOVSKÁ, Ondřej HORÁK, Jan ŠENKYŘÍK, Anna SEEHOFNEROVÁ, Lukáš HOMOLA, Jozef KLUČKA, Jan BLATNÝ, Hana OŠLEJŠKOVÁ and Pavlína DANHOFER.
• Edition: 15th Congress of the European Pediatric Neurology Society (EPNS), Prague, 2023.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30209 Paediatrics
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Organization unit: Faculty of Medicine
• Keywords in English: Brain vasculopathy; COVID-19; Children; SARS-CoV-2; Stroke.

Abstract

SARS-CoV-2 virus causing Coronavirus disease 2019 (COVID-19) like other coronaviruses mainly targets the respiratory system. In symptomatic patients, the most common manifestation is fever, fatigue, cough, and headache. Severe forms can present with pneumonia, acute respiratory distress syndrome, acute cardiac dysfunction, and multiorgan failure. Some studies have indicated an association between COVID-19 and neurovascular conditions. These studies report mainly adult patients with a severe course of the infection. SARS-CoV-2 infects the host through its CoV spike glycoprotein, which binds to the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in the lungs, heart, and kidneys and in endothelial cells. In general, pathophysiological processes after COVID-19 infection can cause vascular affliction and microvascular dysfunction and coagulation abnormalities. It is broadly believed that children usually have a mild case of SARS-CoV-2 infection. However, in connection with the prolong COVID-19 pandemic, we are more likely to see health conditions that have rarely been seen before and that share a common history of recent COVID-19. These cases are intended to present that the course of this infection may not always be benign and a longer period will be needed to assess the consequences of the infection. Further studies will certainly be needed to address the pathophysiological basis in an effort to ensure its optimal diagnostics and treatment in children. This article presents a case series of 3 children who were diagnosed with cerebrovascular disease and whose common denominator was current or previous infection with SARS-CoV-2