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@article{2382877,
author = {Nagaraj, Vignesh Udyavara and Juhasz, Tunde and QuemeandPena, Mayra and Szigyarto, Imola Cs and Bogdan, Dora and Wacha, Andras and Mihaly, Judith and Romanszki, Lorand and Varga, Zoltan and Andreasson, Joakim and Mandity, Istvan and BekeandSomfai, Tamas},
article_location = {WASHINGTON},
article_number = {50},
doi = {http://dx.doi.org/10.1021/acsami.2c11946},
keywords = {self-assembly; liposomes; membrane activity; spiropyran; peptide bilayer; lipid bilaye r fusion},
language = {eng},
issn = {1944-8244},
journal = {ACS APPLIED MATERIALS & INTERFACES},
title = {Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion},
url = {https://pubs.acs.org/doi/10.1021/acsami.2c11946},
volume = {14},
year = {2022}
}
TY - JOUR
ID - 2382877
AU - Nagaraj, Vignesh Udyavara - Juhasz, Tunde - Queme-Pena, Mayra - Szigyarto, Imola Cs - Bogdan, Dora - Wacha, Andras - Mihaly, Judith - Romanszki, Lorand - Varga, Zoltan - Andreasson, Joakim - Mandity, Istvan - Beke-Somfai, Tamas
PY - 2022
TI - Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion
JF - ACS APPLIED MATERIALS & INTERFACES
VL - 14
IS - 50
SP - 55320-55331
EP - 55320-55331
PB - AMER CHEMICAL SOC
SN - 19448244
KW - self-assembly
KW - liposomes
KW - membrane activity
KW - spiropyran
KW - peptide bilayer
KW - lipid bilaye r fusion
UR - https://pubs.acs.org/doi/10.1021/acsami.2c11946
N2 - Self-assembled peptide nanostructures with stimuli-responsive features are promising as functional materials. Despite extensive research efforts, water-soluble supramolecular constructs that can interact with lipid membranes in a controllable way are still challenging to achieve. Here, we have employed a short membrane anchor protein motif (GLFD) and coupled it to a spiropyran photoswitch. Under physiological conditions, these conjugates assemble into similar to 3.5 nm thick, foil-like peptide bilayer morphologies. Photo-isomerization from the closed spiro (SP) form to the open merocyanine (MC) form of the photoswitch triggers rearrangements within the foils. This results in substantial changes in their membrane-binding properties, which also varies sensitively to lipid composition, ranging from reversible nanofoil reformation to stepwise membrane adsorption. The formed peptide layers in the assembly are also able to attach to various liposomes with different surface charges, enabling the fusion of their lipid bilayers. Here, SP-to-MC conversion can be used both to trigger and to modulate the liposome fusion efficiency.
ER -
NAGARAJ, Vignesh Udyavara, Tunde JUHASZ, Mayra QUEME-PENA, Imola Cs SZIGYARTO, Dora BOGDAN, Andras WACHA, Judith MIHALY, Lorand ROMANSZKI, Zoltan VARGA, Joakim ANDREASSON, Istvan MANDITY and Tamas BEKE-SOMFAI. Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion. \textit{ACS APPLIED MATERIALS \&{}amp; INTERFACES}. WASHINGTON: AMER CHEMICAL SOC, 2022, vol.~14, No~50, p.~55320-55331. ISSN~1944-8244. Available from: https://dx.doi.org/10.1021/acsami.2c11946.
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