Cryo-EM structures of Trypanosoma brucei gambiense ISG65
with human complement C3 and C3b and their roles in alternative
pathway restriction

J 2023

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction

SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH et. al.

Základní údaje

Originální název

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction

Autoři

Vydání

Nature Communications, Berlin, Nature, 2023, 2041-1723

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 16.600 v roce 2022

Kód RIV

RIV/00216224:90242/23:00133765

Organizační jednotka

CIISB III

DOI

http://dx.doi.org/10.1038/s41467-023-37988-7

UT WoS

000989625000023

Klíčová slova anglicky

VARIANT SURFACE GLYCOPROTEIN; ANTIGENIC DETERMINANTS; SPONTANEOUS HYDROLYSIS; HUMAN-SERUM; PROTEIN; resistance

Štítky

CF BIC, CF CRYO, ne MU, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 4. 2024 23:11, Mgr. Michal Petr

Anotace

V originále

African Trypanosomes have developed elaborate immune evasion mechanisms. Here, the authors present the cryoelectron microscopy structures of a trypanosome surface receptor with human complement C3 and C3b, revealing several modes of complement interaction.

Návaznosti

90242, velká výzkumná infrastruktura

Název: CIISB III

Citovat

SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH, Jitka VOTRUBOVA, Farnaz ZAHEDIFARD, Adriana SUBRTOVA, Marie SAFNER, Martin HUBALEK, Maaike THOMPSON, Martin ZOLTNER a Sebastian ZOLL. Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. Nature Communications. Berlin: Nature, 2023, roč. 14, č. 1, s. 1-18. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-023-37988-7.

@article{2383601,
 author = {Sulzen, Hagen and Began, Jakub and Dhillon, Arun and Kereiche, Sami and Pompach, Petr and Votrubova, Jitka and Zahedifard, Farnaz and Subrtova, Adriana and Safner, Marie and Hubalek, Martin and Thompson, Maaike and Zoltner, Martin and Zoll, Sebastian},
 article_location = {Berlin},
 article_number = {1},
 doi = {http://dx.doi.org/10.1038/s41467-023-37988-7},
 keywords = {VARIANT SURFACE GLYCOPROTEIN; ANTIGENIC DETERMINANTS; SPONTANEOUS HYDROLYSIS; HUMAN-SERUM; PROTEIN; resistance},
 language = {eng},
 issn = {2041-1723},
 journal = {Nature Communications},
 title = {Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction},
 url = {https://www.nature.com/articles/s41467-023-37988-7},
 volume = {14},
 year = {2023}
}

TY - JOUR
ID - 2383601
AU - Sulzen, Hagen - Began, Jakub - Dhillon, Arun - Kereiche, Sami - Pompach, Petr - Votrubova, Jitka - Zahedifard, Farnaz - Subrtova, Adriana - Safner, Marie - Hubalek, Martin - Thompson, Maaike - Zoltner, Martin - Zoll, Sebastian
PY - 2023
TI - Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction
JF - Nature Communications
VL - 14
IS - 1
SP - 1-18
EP - 1-18
PB - Nature
SN - 20411723
KW - VARIANT SURFACE GLYCOPROTEIN
KW - ANTIGENIC DETERMINANTS
KW - SPONTANEOUS HYDROLYSIS
KW - HUMAN-SERUM
KW - PROTEIN
KW - resistance
UR - https://www.nature.com/articles/s41467-023-37988-7
N2 - African Trypanosomes have developed elaborate immune evasion mechanisms. Here, the authors present the cryoelectron microscopy structures of a trypanosome surface receptor with human complement C3 and C3b, revealing several modes of complement interaction.
ER -

SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH, Jitka VOTRUBOVA, Farnaz ZAHEDIFARD, Adriana SUBRTOVA, Marie SAFNER, Martin HUBALEK, Maaike THOMPSON, Martin ZOLTNER a Sebastian ZOLL. Cryo-EM structures of \&{}lt;i\&{}gt;Trypanosoma brucei gambiense\&{}lt;/i\&{}gt; ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. \textit{Nature Communications}. Berlin: Nature, 2023, roč.~14, č.~1, s.~1-18. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-023-37988-7.

Podrobný výpis o publikaci

Cryo-EM structures of <i>Trypanosoma brucei gambiense</i> ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction