Striato-cortical functional connectivity changes in mild
cognitive impairment with Lewy bodies

J 2024

Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Marek BARTOŇ, Luboš BRABENEC, Žaneta ŽELEZNÍKOVÁ et. al.

Základní údaje

Originální název

Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

Autoři

NOVÁKOVÁ, Ľubomíra (703 Slovensko, garant, domácí), Martin GAJDOŠ (203 Česká republika, domácí), Marek BARTOŇ (203 Česká republika, domácí), Luboš BRABENEC (203 Česká republika, domácí), Žaneta ŽELEZNÍKOVÁ (703 Slovensko, domácí), Ivona MORÁVKOVÁ (703 Slovensko, domácí) a Irena REKTOROVÁ (203 Česká republika, domácí)

Vydání

PARKINSONISM & RELATED DISORDERS, London, ELSEVIER SCI LTD, 2024, 1353-8020

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.parkreldis.2024.106031

UT WoS

001188128400001

Klíčová slova anglicky

striatum; functional connectivity; MCI; Lewy bodies

Štítky

14110127, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 8. 2024 10:58, Mgr. Tereza Miškechová

Anotace

V originále

Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre-dementia phase are scarce. Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition. Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender-matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed-based connectivity of the dorsal, middle, and ventral striatum. We assessed correlations between functional connectivity in the regions of between-group differences and neuropsychological scores of interest (visuospatial and executive domains z-scores). Results: Subjects with Mild Cognitive Impairment with Lewy Bodies, as compared to healthy controls, showed increased connectivity from the dorsal part of the striatum particularly to the bilateral anterior part of the temporal cortex with an association with executive functions. Conclusions: We were able to capture early abnormal connectivity within cholinergic and noradrenergic pathways that correlated with cognitive functions known to be linked to cholinergic/noradrenergic deficits. The knowledge of specific alterations may improve our understanding of early neural changes in pre-dementia stages and enhance research of disease modifying therapy.

Návaznosti

LM2018129, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NU20-04-00294, projekt VaV

Název: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministerstvo zdravotnictví ČR, Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Marek BARTOŇ, Luboš BRABENEC, Žaneta ŽELEZNÍKOVÁ, Ivona MORÁVKOVÁ a Irena REKTOROVÁ. Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies. PARKINSONISM & RELATED DISORDERS. London: ELSEVIER SCI LTD, 2024, roč. 121, April 2024, s. 1-8. ISSN 1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2024.106031.

@article{2384097,
   author = {Nováková, Ľubomíra and Gajdoš, Martin and Bartoň, Marek and Brabenec, Luboš and Železníková, Žaneta and Morávková, Ivona and Rektorová, Irena},
   article_location = {London},
   article_number = {April 2024},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2024.106031},
   keywords = {striatum; functional connectivity; MCI; Lewy bodies},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies},
   url = {https://www.prd-journal.com/article/S1353-8020(24)00043-9/abstract},
   volume = {121},
   year = {2024}
}

TY  - JOUR
ID  - 2384097
AU  - Nováková, Ľubomíra - Gajdoš, Martin - Bartoň, Marek - Brabenec, Luboš - Železníková, Žaneta - Morávková, Ivona - Rektorová, Irena
PY  - 2024
TI  - Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 121
IS  - April 2024
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - striatum
KW  - functional connectivity
KW  - MCI
KW  - Lewy bodies
UR  - https://www.prd-journal.com/article/S1353-8020(24)00043-9/abstract
N2  - Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre-dementia phase are scarce. Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition. Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender-matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed-based connectivity of the dorsal, middle, and ventral striatum. We assessed correlations between functional connectivity in the regions of between-group differences and neuropsychological scores of interest (visuospatial and executive domains z-scores). Results: Subjects with Mild Cognitive Impairment with Lewy Bodies, as compared to healthy controls, showed increased connectivity from the dorsal part of the striatum particularly to the bilateral anterior part of the temporal cortex with an association with executive functions. Conclusions: We were able to capture early abnormal connectivity within cholinergic and noradrenergic pathways that correlated with cognitive functions known to be linked to cholinergic/noradrenergic deficits. The knowledge of specific alterations may improve our understanding of early neural changes in pre-dementia stages and enhance research of disease modifying therapy.
ER  -

NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Marek BARTOŇ, Luboš BRABENEC, Žaneta ŽELEZNÍKOVÁ, Ivona MORÁVKOVÁ a Irena REKTOROVÁ. Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies. \textit{PARKINSONISM \&{} RELATED DISORDERS}. London: ELSEVIER SCI LTD, 2024, roč.~121, April 2024, s.~1-8. ISSN~1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2024.106031.

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