POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335
POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

J 2023

POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

HUBACEK, Jaroslav A, Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK, Dana DLOUHA et. al.

Základní údaje

Originální název

POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

Autoři

HUBACEK, Jaroslav A (203 Česká republika), Tom PHILIPP (203 Česká republika), Vera ADAMKOVA (203 Česká republika), Ondřej MÁJEK (203 Česká republika, domácí), Dana DLOUHA (203 Česká republika) a Ladislav DUŠEK (203 Česká republika, domácí)

Vydání

Central European journal of public health, Praha, Česká lékařská společnost J.E. Purkyně, 2023, 1210-7778

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.200 v roce 2022

Kód RIV

RIV/00216224:14110/23:00133875

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.21101/cejph.a7906

UT WoS

001166654700002

Klíčová slova anglicky

COVID-19; DPP4; OAS1; polymorphism; SARS-CoV-2; severity; TMPRSS6; ZNF335

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 3. 2024 09:34, Mgr. Tereza Miškechová

Anotace

V originále

Objectives: The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19. Methods: We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown). Results: Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors. Conclusions: Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study.

Citovat

HUBACEK, Jaroslav A, Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK, Dana DLOUHA a Ladislav DUŠEK. POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION. Central European journal of public health. Praha: Česká lékařská společnost J.E. Purkyně, 2023, roč. 31, č. 4, s. 235-239. ISSN 1210-7778. Dostupné z: https://dx.doi.org/10.21101/cejph.a7906.

@article{2386697,
   author = {Hubacek, Jaroslav A and Philipp, Tom and Adamkova, Vera and Májek, Ondřej and Dlouha, Dana and Dušek, Ladislav},
   article_location = {Praha},
   article_number = {4},
   doi = {http://dx.doi.org/10.21101/cejph.a7906},
   keywords = {COVID-19; DPP4; OAS1; polymorphism; SARS-CoV-2; severity; TMPRSS6; ZNF335},
   language = {eng},
   issn = {1210-7778},
   journal = {Central European journal of public health},
   title = {POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION},
   url = {https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php},
   volume = {31},
   year = {2023}
}

TY  - JOUR
ID  - 2386697
AU  - Hubacek, Jaroslav A - Philipp, Tom - Adamkova, Vera - Májek, Ondřej - Dlouha, Dana - Dušek, Ladislav
PY  - 2023
TI  - POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION
JF  - Central European journal of public health
VL  - 31
IS  - 4
SP  - 235-239
EP  - 235-239
PB  - Česká lékařská společnost J.E. Purkyně
SN  - 12107778
KW  - COVID-19
KW  - DPP4
KW  - OAS1
KW  - polymorphism
KW  - SARS-CoV-2
KW  - severity
KW  - TMPRSS6
KW  - ZNF335
UR  - https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php
N2  - Objectives: The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19. Methods: We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown). Results: Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors. Conclusions: Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study.
ER  -

HUBACEK, Jaroslav A, Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK, Dana DLOUHA a Ladislav DUŠEK. POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION. \textit{Central European journal of public health}. Praha: Česká lékařská společnost J.E. Purkyně, 2023, roč.~31, č.~4, s.~235-239. ISSN~1210-7778. Dostupné z: https://dx.doi.org/10.21101/cejph.a7906.

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