Chromosome Division in Early Embryos-Is Everything under
Control? And Is the Cell Size Important?

J 2024

Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?

HORÁKOVÁ, Adéla, Markéta KONEČNÁ a Martin ANGER

Základní údaje

Originální název

Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?

Autoři

HORÁKOVÁ, Adéla (203 Česká republika, domácí), Markéta KONEČNÁ (203 Česká republika, domácí) a Martin ANGER (203 Česká republika)

Vydání

International Journal of Molecular Sciences, MDPI, 2024, 1661-6596

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10605 Developmental biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.600 v roce 2022

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/ijms25042101

UT WoS

001172049100001

Klíčová slova anglicky

spindle; chromosome division; segregation errors; spindle assembly checkpoint; embryo; CDK1; cell size; aneuploidy

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 3. 2024 09:40, Mgr. Marie Šípková, DiS.

Anotace

V originále

Chromosome segregation in female germ cells and early embryonic blastomeres is known to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of termination of early development and embryo loss in mammals. And in specific cases, when the aneuploidy is actually compatible with embryonic and fetal development, it leads to severe developmental disorders. The main surveillance mechanism, which is essential for the fidelity of chromosome segregation, is the Spindle Assembly Checkpoint (SAC). And although all eukaryotic cells carry genes required for SAC, it is not clear whether this pathway is active in all cell types, including blastomeres of early embryos. In this review, we will summarize and discuss the recent progress in our understanding of the mechanisms controlling chromosome segregation and how they might work in embryos and mammalian embryos in particular. Our conclusion from the current literature is that the early mammalian embryos show limited capabilities to react to chromosome segregation defects, which might, at least partially, explain the widespread problem of aneuploidy during the early development in mammals.

Citovat

HORÁKOVÁ, Adéla, Markéta KONEČNÁ a Martin ANGER. Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important? International Journal of Molecular Sciences. MDPI, 2024, roč. 25, č. 4, s. 1-14. ISSN 1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms25042101.

@article{2387599,
   author = {Horáková, Adéla and Konečná, Markéta and Anger, Martin},
   article_number = {4},
   doi = {http://dx.doi.org/10.3390/ijms25042101},
   keywords = {spindle; chromosome division; segregation errors; spindle assembly checkpoint; embryo; CDK1; cell size; aneuploidy},
   language = {eng},
   issn = {1661-6596},
   journal = {International Journal of Molecular Sciences},
   title = {Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?},
   url = {https://www.mdpi.com/1422-0067/25/4/2101},
   volume = {25},
   year = {2024}
}

TY  - JOUR
ID  - 2387599
AU  - Horáková, Adéla - Konečná, Markéta - Anger, Martin
PY  - 2024
TI  - Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?
JF  - International Journal of Molecular Sciences
VL  - 25
IS  - 4
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 16616596
KW  - spindle
KW  - chromosome division
KW  - segregation errors
KW  - spindle assembly checkpoint
KW  - embryo
KW  - CDK1
KW  - cell size
KW  - aneuploidy
UR  - https://www.mdpi.com/1422-0067/25/4/2101
N2  - Chromosome segregation in female germ cells and early embryonic blastomeres is known to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of termination of early development and embryo loss in mammals. And in specific cases, when the aneuploidy is actually compatible with embryonic and fetal development, it leads to severe developmental disorders. The main surveillance mechanism, which is essential for the fidelity of chromosome segregation, is the Spindle Assembly Checkpoint (SAC). And although all eukaryotic cells carry genes required for SAC, it is not clear whether this pathway is active in all cell types, including blastomeres of early embryos. In this review, we will summarize and discuss the recent progress in our understanding of the mechanisms controlling chromosome segregation and how they might work in embryos and mammalian embryos in particular. Our conclusion from the current literature is that the early mammalian embryos show limited capabilities to react to chromosome segregation defects, which might, at least partially, explain the widespread problem of aneuploidy during the early development in mammals.
ER  -

HORÁKOVÁ, Adéla, Markéta KONEČNÁ a Martin ANGER. Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important? \textit{International Journal of Molecular Sciences}. MDPI, 2024, roč.~25, č.~4, s.~1-14. ISSN~1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms25042101.

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