J 2023

The observational clinical registry (cohort design) of the European Reference Network on Rare Adult Solid Cancers: The protocol for the rare head and neck cancers

TRAMA, Annalisa, Lisa LICITRA, Stefano CAVALIERI, Simone BONFARNUZZO, Paolo BAILI et. al.

Základní údaje

Originální název

The observational clinical registry (cohort design) of the European Reference Network on Rare Adult Solid Cancers: The protocol for the rare head and neck cancers

Autoři

TRAMA, Annalisa, Lisa LICITRA, Stefano CAVALIERI, Simone BONFARNUZZO, Paolo BAILI, Antonio CIARFELLA, Pablo PARENTE, Giovanni ALMADORI, Mohssen ANSARIN, Almalina BACIGALUPO, Philipp BAUMEISTER, Bertrand BAUJAT, Paolo BOSSI, Elisa CAVALERA, Maria Cecilia CERCATO, Francois DIELEMAN, Nicolas FAKHRY, Virginia FERRARESI, Francesca GAINO, Danilo GALIZIA, Jana HALÁMKOVÁ (203 Česká republika, domácí), Elina HALME, Jose HARDILLO, Benedikt HOFAUER, Emma KINLOCH, Lorenzo LIVI, Laura Deborah LOCATI, Stefan MATTHEIS, Giuseppe MERCANTE, Aurora MIRABILE, Gabriele MOLTENI, Ester ORLANDI, Roberto PERSIO, Stefania SCIALLERO, Ludi SMEELE, Marta TAGLIABUE, Valentino VALENTINI, Van Harpen CARLA, Christoph Benedikt WESTPHALEN a Laura BOTTA

Vydání

Plos one, San Francisco, Public Library of Science, 2023, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 3.700 v roce 2022

Kód RIV

RIV/00216224:14110/23:00133907

Organizační jednotka

Lékařská fakulta

UT WoS

000985134400045

Klíčová slova anglicky

Rare Adult Solid Cancers

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 27. 3. 2024 07:36, Mgr. Tereza Miškechová

Anotace

V originále

IntroductionCare for head and neck cancers is complex in particular for the rare ones. Knowledge is limited and histological heterogeneity adds complexity to the rarity. There is a wide consensus that to support clinical research on rare cancer, clinical registries should be developed within networks specializing in rare cancers. In the EU, a unique opportunity is provided by the European Reference Networks (ERN). The ERN EURACAN is dedicated to rare adults solid cancers, here we present the protocol of the EURACAN registry on rare head and neck cancers (ClinicalTrials.gov Identifier: NCT05483374). Study designRegistry-based cohort study including only people with rare head and neck cancers. Objectives to help describe the natural history of rare head and neck cancers;to evaluate factors that influence prognosis;to assess treatment effectiveness;to measure indicators of quality of care. MethodsSettings and participantsIt is an hospital based registry established in hospitals with expertise in head and neck cancers. Only adult patients with epithelial tumours of nasopharynx; nasal cavity and paranasal sinuses; salivary gland cancer in large and small salivary glands; and middle ear will be included in the registry. This registry won't select a sample of patients. Each patient in the facility who meets the above mentioned inclusion criteria will be followed prospectively and longitudinally with follow-up at cancer progression and / or cancer relapse or patient death. It is a secondary use of data which will be collected from the clinical records. The data collected for the registry will not entail further examinations or admissions to the facility and/or additional appointments to those normally provided for the patient follow-up.VariablesData will be collected on patient characteristics (eg. patient demographics, lifestyle, medical history, health status); exposure data (eg. disease, procedures, treatments of interest) and outcomes (e.g. survival, progression, progression-free survival, etc.). In addition, data on potential confounders (e.g. comorbidity; functional status etc.) will be also collected.Statistical methodsThe data analyses will include descriptive statistics showing patterns of patients' and cancers' variables and indicators describing the quality of care. Multivariable Cox's proportional hazards model and Hazard ratios (HR) for all-cause or cause specific mortality will be used to determine independent predictors of overall survival, recurrence etc. Variables to include in the multivariable regression model will be selected based on the results of univariable analysis. The role of confounding or effect modifiers will be evaluated using stratified analysis or sensitivity analysis. To assess treatment effectiveness, multivariable models with propensity score adjustment and progression-free survival will be performed. Adequate statistical (eg. marginal structural model) methods will be used if time-varying treatments/confounders and confounding by indication (selective prescribing) will be present. ResultsThe registry initiated recruiting in May 2022. The estimated completion date is December 2030 upon agreement on the achievement of all the registry objectives. As of October 2022, the registry is recruiting. There will be a risk of limited representativeness due to the hospital-based nature of the registry and to the fact that hospital contributing to the registry are expert centres for these rare cancers.