Development of highly porous metasilicate pellets for unique
use in chemical warfare agent detection systems

a 2024

Development of highly porous metasilicate pellets for unique use in chemical warfare agent detection systems

ZEMAN, Jiří, Sylvie PAVLOKOVÁ, David VETCHÝ, Zdeněk MORAVEC, Lukáš MATĚJOVSKÝ et. al.

Základní údaje

Originální název

Development of highly porous metasilicate pellets for unique use in chemical warfare agent detection systems

Autoři

ZEMAN, Jiří (203 Česká republika, garant, domácí), Sylvie PAVLOKOVÁ (203 Česká republika, domácí), David VETCHÝ (203 Česká republika, domácí), Zdeněk MORAVEC (203 Česká republika, domácí), Lukáš MATĚJOVSKÝ (203 Česká republika) a Vladimír PITSCHMANN (203 Česká republika)

Vydání

14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2024

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Webová stránka konference

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

pellets; metasilicate; detection tube; chemical warfare agent; phosgene; diphosgene; porosity; volatile substance; menthol; camphor

Změněno: 28. 3. 2024 10:42, PharmDr. Jiří Zeman, Ph.D.

Anotace

V originále

Extrusion/spheronization is one of the many methods of pharmaceutical technology. This method produces highly spherical particles called pellets with a uniform shape and particle size distribution. Such particles can also be used in other scientific fields, for example, in analytical chemistry, where detection reagents can be adsorbed on the surface of the pellets and subsequently used for detection purposes. In practice, they are used as carriers in detection tubes (DTs), which are part of the equipment of some armies and rescue services and are mainly used to detect chemical warfare agents (CWAs). This study aimed to prepare innovative carriers in the form of highly porous composite pellets that would have the above-mentioned properties and also high specific surface area (SSA) and thus be suitable for interdisciplinary applications, especially for second-generation DTs. To achieve that, a mesoporous, amorphous magnesium aluminometasilicate – Neusilin® US2 with high SSA (300 m2/g) was utilized. To form pores and thus further increase the SSA of the prepared pellets, volatile substances (VSs) such as menthol (M) and camphor (C) were added to the powder mixture in various concentrations. Subsequent drying of the samples at 60 °C removed these volatiles, creating pores and increasing the SSA of the carriers. In cooperation with Oritest (Prague, Czech Republic), the most promising samples were subsequently impregnated with o-phenylenediamine-pyronine (PY-OPD) as a second-generation detection reagent and tested for the presence of diphosgene/phosgene.

Návaznosti

VI20192022172, projekt VaV

Název: Detekční trubičky druhé generace pro kontinuální a opakované monitorování nervově paralytických a jiných toxických látek

Investor: Ministerstvo vnitra ČR, Detekční trubičky druhé generace pro kontinuální a opakované monitorování nervově paralytických a jiných toxických látek

Citovat

ZEMAN, Jiří, Sylvie PAVLOKOVÁ, David VETCHÝ, Zdeněk MORAVEC, Lukáš MATĚJOVSKÝ a Vladimír PITSCHMANN. Development of highly porous metasilicate pellets for unique use in chemical warfare agent detection systems. In 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 2024.

@proceedings{2388557,
   author = {Zeman, Jiří and Pavloková, Sylvie and Vetchý, David and Moravec, Zdeněk and Matějovský, Lukáš and Pitschmann, Vladimír},
   booktitle = {14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology},
   keywords = {pellets; metasilicate; detection tube; chemical warfare agent; phosgene; diphosgene; porosity; volatile substance; menthol; camphor},
   language = {eng},
   title = {Development of highly porous metasilicate pellets for unique use in chemical warfare agent detection systems},
   url = {https://www.worldmeeting.org/home/},
   year = {2024}
}

TY  - CONF
ID  - 2388557
AU  - Zeman, Jiří - Pavloková, Sylvie - Vetchý, David - Moravec, Zdeněk - Matějovský, Lukáš - Pitschmann, Vladimír
PY  - 2024
TI  - Development of highly porous metasilicate pellets for unique use in chemical warfare agent detection systems
KW  - pellets
KW  - metasilicate
KW  - detection tube
KW  - chemical warfare agent
KW  - phosgene
KW  - diphosgene
KW  - porosity
KW  - volatile substance
KW  - menthol
KW  - camphor
UR  - https://www.worldmeeting.org/home/
N2  - Extrusion/spheronization is one of the many methods of pharmaceutical technology. This method produces highly spherical particles called pellets with a uniform shape and particle size distribution. Such particles can also be used in other scientific fields, for example, in analytical chemistry, where detection reagents can be adsorbed on the surface of the pellets and subsequently used for detection purposes. In practice, they are used as carriers in detection tubes (DTs), which are part of the equipment of some armies and rescue services and are mainly used to detect chemical warfare agents (CWAs). This study aimed to prepare innovative carriers in the form of highly porous composite pellets that would have the above-mentioned properties and also high specific surface area (SSA) and thus be suitable for interdisciplinary applications, especially for second-generation DTs. To achieve that, a mesoporous, amorphous magnesium aluminometasilicate – Neusilin® US2 with high SSA (300 m2/g) was utilized. To form pores and thus further increase the SSA of the prepared pellets, volatile substances (VSs) such as menthol (M) and camphor (C) were added to the powder mixture in various concentrations. Subsequent drying of the samples at 60 °C removed these volatiles, creating pores and increasing the SSA of the carriers. In cooperation with Oritest (Prague, Czech Republic), the most promising samples were subsequently impregnated with o-phenylenediamine-pyronine (PY-OPD) as a second-generation detection reagent and tested for the presence of diphosgene/phosgene.
ER  -

ZEMAN, Jiří, Sylvie PAVLOKOVÁ, David VETCHÝ, Zdeněk MORAVEC, Lukáš MATĚJOVSKÝ a Vladimír PITSCHMANN. Development of highly porous metasilicate pellets for unique use in chemical warfare agent detection systems. In \textit{14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}. 2024.

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