| LIRUSSI, Frederic, Kyrylo PYRSHEV, Semen YESYLEVSKYY, Timothée Emmanuel Jonathan RIVEL, Tatiana LOPEZ, Eleonore COPPENS, Simona MURA, Patrick COUVREUR a Christophe RAMSEYER. Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. Biochimica et Biophysica Acta - Molecular Basis of Disease. Amsterdam: ELSEVIER SCIENCE BV, 2023, roč. 1869, č. 2, s. 1-12. ISSN 0925-4439. Dostupné z: https://dx.doi.org/10.1016/j.bbadis.2022.166614. |
Další formáty:
BibTeX
LaTeX
RIS
@article{2392899,
author = {Lirussi, Frederic and Pyrshev, Kyrylo and Yesylevskyy, Semen and Rivel, Timothée Emmanuel Jonathan and Lopez, Tatiana and Coppens, Eleonore and Mura, Simona and Couvreur, Patrick and Ramseyer, Christophe},
article_location = {Amsterdam},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.bbadis.2022.166614},
keywords = {Gemcitabine-squalene; Nanomedicine; Lipid composition; Selective delivery; Plasma membrane; Cancer targeting},
language = {eng},
issn = {0925-4439},
journal = {Biochimica et Biophysica Acta - Molecular Basis of Disease},
title = {Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells},
url = {https://www.sciencedirect.com/science/article/pii/S092544392200285X?via%3Dihub},
volume = {1869},
year = {2023}
}
TY - JOUR
ID - 2392899
AU - Lirussi, Frederic - Pyrshev, Kyrylo - Yesylevskyy, Semen - Rivel, Timothée Emmanuel Jonathan - Lopez, Tatiana - Coppens, Eleonore - Mura, Simona - Couvreur, Patrick - Ramseyer, Christophe
PY - 2023
TI - Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
VL - 1869
IS - 2
SP - 1-12
EP - 1-12
PB - ELSEVIER SCIENCE BV
SN - 09254439
KW - Gemcitabine-squalene
KW - Nanomedicine
KW - Lipid composition
KW - Selective delivery
KW - Plasma membrane
KW - Cancer targeting
UR - https://www.sciencedirect.com/science/article/pii/S092544392200285X?via%3Dihub
N2 - Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the plasma membrane is druggable and suitable for facilitating selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from radioactive assays, fluorescent membrane probes and molecular dynamics simulations provide evidence of selective accumulation of gemcitabine-squalene in the plasma membranes with disrupted lipid asymmetry and its subsequent preferential uptake by malignant cells. This causes pronounced cytotoxicity on cancer cells in comparison to their benign counterparts originating from the same tissue.
ER -
LIRUSSI, Frederic, Kyrylo PYRSHEV, Semen YESYLEVSKYY, Timothée Emmanuel Jonathan RIVEL, Tatiana LOPEZ, Eleonore COPPENS, Simona MURA, Patrick COUVREUR a Christophe RAMSEYER. Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. \textit{Biochimica et Biophysica Acta - Molecular Basis of Disease}. Amsterdam: ELSEVIER SCIENCE BV, 2023, roč.~1869, č.~2, s.~1-12. ISSN~0925-4439. Dostupné z: https://dx.doi.org/10.1016/j.bbadis.2022.166614.
|
