LIRUSSI, Frederic, Kyrylo PYRSHEV, Semen YESYLEVSKYY, Timothée Emmanuel Jonathan RIVEL, Tatiana LOPEZ, Eleonore COPPENS, Simona MURA, Patrick COUVREUR a Christophe RAMSEYER. Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. Biochimica et Biophysica Acta - Molecular Basis of Disease. Amsterdam: ELSEVIER SCIENCE BV, 2023, roč. 1869, č. 2, s. 1-12. ISSN 0925-4439. Dostupné z: https://dx.doi.org/10.1016/j.bbadis.2022.166614. |
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@article{2392899, author = {Lirussi, Frederic and Pyrshev, Kyrylo and Yesylevskyy, Semen and Rivel, Timothée Emmanuel Jonathan and Lopez, Tatiana and Coppens, Eleonore and Mura, Simona and Couvreur, Patrick and Ramseyer, Christophe}, article_location = {Amsterdam}, article_number = {2}, doi = {http://dx.doi.org/10.1016/j.bbadis.2022.166614}, keywords = {Gemcitabine-squalene; Nanomedicine; Lipid composition; Selective delivery; Plasma membrane; Cancer targeting}, language = {eng}, issn = {0925-4439}, journal = {Biochimica et Biophysica Acta - Molecular Basis of Disease}, title = {Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells}, url = {https://www.sciencedirect.com/science/article/pii/S092544392200285X?via%3Dihub}, volume = {1869}, year = {2023} }
TY - JOUR ID - 2392899 AU - Lirussi, Frederic - Pyrshev, Kyrylo - Yesylevskyy, Semen - Rivel, Timothée Emmanuel Jonathan - Lopez, Tatiana - Coppens, Eleonore - Mura, Simona - Couvreur, Patrick - Ramseyer, Christophe PY - 2023 TI - Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells JF - Biochimica et Biophysica Acta - Molecular Basis of Disease VL - 1869 IS - 2 SP - 1-12 EP - 1-12 PB - ELSEVIER SCIENCE BV SN - 09254439 KW - Gemcitabine-squalene KW - Nanomedicine KW - Lipid composition KW - Selective delivery KW - Plasma membrane KW - Cancer targeting UR - https://www.sciencedirect.com/science/article/pii/S092544392200285X?via%3Dihub N2 - Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the plasma membrane is druggable and suitable for facilitating selective delivery of amphiphilic gemcitabine-squalene nanomedicines to cancer cells. Data from radioactive assays, fluorescent membrane probes and molecular dynamics simulations provide evidence of selective accumulation of gemcitabine-squalene in the plasma membranes with disrupted lipid asymmetry and its subsequent preferential uptake by malignant cells. This causes pronounced cytotoxicity on cancer cells in comparison to their benign counterparts originating from the same tissue. ER -
LIRUSSI, Frederic, Kyrylo PYRSHEV, Semen YESYLEVSKYY, Timothée Emmanuel Jonathan RIVEL, Tatiana LOPEZ, Eleonore COPPENS, Simona MURA, Patrick COUVREUR a Christophe RAMSEYER. Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. \textit{Biochimica et Biophysica Acta - Molecular Basis of Disease}. Amsterdam: ELSEVIER SCIENCE BV, 2023, roč.~1869, č.~2, s.~1-12. ISSN~0925-4439. Dostupné z: https://dx.doi.org/10.1016/j.bbadis.2022.166614.
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