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@proceedings{2393304,
author = {Koutná, Gabriela and Muselík, Jan and Kubová, Kateřina and Vysloužil, Jakub and Vetchý, David and Kotouček, Jan and Mašek, Josef},
booktitle = {14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology},
keywords = {self-microemulsifying system; thymol; stability; solidification},
language = {eng},
title = {Stability and solidification of thymol-loaded self-microemulsifying drug delivery system},
year = {2024}
}
TY - CONF
ID - 2393304
AU - Koutná, Gabriela - Muselík, Jan - Kubová, Kateřina - Vysloužil, Jakub - Vetchý, David - Kotouček, Jan - Mašek, Josef
PY - 2024
TI - Stability and solidification of thymol-loaded self-microemulsifying drug delivery system
KW - self-microemulsifying system
KW - thymol
KW - stability
KW - solidification
N2 - Self-emulsifying drug delivery systems (SEDDS) have gained recognition as a crucial approach to enhancing the bioavailability of poorly water-soluble drugs. Thymol boasts a plethora of biological effects, such as anti-inflammatory, antioxidant, immunomodulatory, and analgesic properties. Thymol is a GRAS candidate for preventing and treating inflammatory bowel diseases. Given their limited bioavailability, thymol presents a promising candidate for inclusion in self-emulsifying systems. Nevertheless, liquid SEDDS pose challenges, including the potential irritation caused by a high surfactant content on the gastrointestinal mucosa, reduced formulation stability, and complexities in handling. Solid SEDDS, conversely, are solidified self-emulsifying formulations achieved by converting liquid SEDDS into self-emulsifying powders or particles. Neusilin® US2 was chosen as the solid carrier for thymol SMEDDS formulation. The optimized T-SMEDDS formulations underwent long-term stability tests, and six months stability was demonstrated. The optimal ratio of T-SMEDDS formulation with the solid carrier Neusilin® US2 was 2:1. In vitro dissolution characteristics was determined using biorelevant media FaSSIF. The release of more than 85% of thymol from the T-SMEEDS formulation within 15 minutes indicates a reasonable presumption for enhanced thymol bioavailability in the biosystem.
ER -
KOUTNÁ, Gabriela, Jan MUSELÍK, Kateřina KUBOVÁ, Jakub VYSLOUŽIL, David VETCHÝ, Jan KOTOUČEK a Josef MAŠEK. Stability and solidification of thymol-loaded self-microemulsifying drug delivery system. In \textit{14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}. 2024.
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