Aryl hydrocarbon receptor as a drug target in advanced prostate
cancer therapy - obstacles and perspectives

J 2024

Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives

PROCHÁZKOVÁ, Jiřina, Zuzana KAHOUNOVA, Jan VONDRÁČEK a Karel SOUČEK

Základní údaje

Originální název

Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives

Autoři

PROCHÁZKOVÁ, Jiřina, Zuzana KAHOUNOVA, Jan VONDRÁČEK a Karel SOUČEK

Vydání

TRANSCRIPTION-AUSTIN, UNITED STATES, TAYLOR & FRANCIS INC, 2024, 2154-1264

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.600 v roce 2022

DOI

http://dx.doi.org/10.1080/21541264.2024.2334106

UT WoS

001194216100001

Klíčová slova anglicky

Aryl hydrocarbon receptor; prostate cancer; castration resistance; antibody-drug conjugates

Změněno: 25. 4. 2024 19:28, Mgr. Jiřina Procházková, Ph.D.

Anotace

V originále

Aryl hydrocarbon receptor (AhR) is a transcription factor that is primarily known as an intracellular sensor of environmental pollution. After five decades, the list of synthetic and toxic chemicals that activate AhR signaling has been extended to include a number of endogenous compounds produced by various types of cells via their metabolic activity. AhR signaling is active from the very beginning of embryonal development throughout the life cycle and participates in numerous biological processes such as control of cell proliferation and differentiation, metabolism of aromatic compounds of endogenous and exogenous origin, tissue regeneration and stratification, immune system development and polarization, control of stemness potential, and homeostasis maintenance. AhR signaling can be affected by various pharmaceuticals that may help modulate abnormal AhR signaling and drive pathological states. Given their role in immune system development and regulation, AhR antagonistic ligands are attractive candidates for immunotherapy of disease states such as advanced prostate cancer, where an aberrant immune microenvironment contributes to cancer progression and needs to be reeducated. Advanced stages of prostate cancer are therapeutically challenging and characterized by decreased overall survival (OS) due to the metastatic burden. Therefore, this review addresses the role of AhR signaling in the development and progression of prostate cancer and discusses the potential of AhR as a drug target for the treatment of advanced prostate cancer upon entering the phase of drug resistance and failure of first-line androgen deprivation therapy.Abbreviation: ADC: antibody-drug conjugate; ADT: androgen deprivation therapy; AhR: aryl hydrocarbon receptor; AR: androgen receptor; ARE: androgen response element; ARPI: androgen receptor pathway inhibitor; mCRPC: metastatic castration-resistant prostate cancer; DHT: 5a-dihydrotestosterone; FICZ: 6-formylindolo[3,2-b]carbazole; 3-MC: 3-methylcholanthrene; 6-MCDF: 6-methyl-1,3,8-trichlorodibenzofuran; MDSCs: myeloid-derived suppressor cells; PAHs: polycyclic aromatic hydrocarbons; PCa: prostate cancer; TAMs: tumor-associated macrophages; TF: transcription factor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TME: tumor microenvironment; TRAMP: transgenic adenocarcinoma of the mouse prostate; TROP2: tumor associated calcium signal transducer 2

Citovat

PROCHÁZKOVÁ, Jiřina, Zuzana KAHOUNOVA, Jan VONDRÁČEK a Karel SOUČEK. Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives. TRANSCRIPTION-AUSTIN. UNITED STATES: TAYLOR & FRANCIS INC, 2024, 20 s. ISSN 2154-1264. Dostupné z: https://dx.doi.org/10.1080/21541264.2024.2334106.

@article{2397077,
   author = {Procházková, Jiřina and Kahounova, Zuzana and Vondráček, Jan and Souček, Karel},
   article_location = {UNITED STATES},
   doi = {http://dx.doi.org/10.1080/21541264.2024.2334106},
   keywords = {Aryl hydrocarbon receptor; prostate cancer; castration resistance; antibody-drug conjugates},
   issn = {2154-1264},
   journal = {TRANSCRIPTION-AUSTIN},
   title = {Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives},
   year = {2024}
}

TY  - JOUR
ID  - 2397077
AU  - Procházková, Jiřina - Kahounova, Zuzana - Vondráček, Jan - Souček, Karel
PY  - 2024
TI  - Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives
JF  - TRANSCRIPTION-AUSTIN
PB  - TAYLOR & FRANCIS INC
SN  - 21541264
KW  - Aryl hydrocarbon receptor
KW  - prostate cancer
KW  - castration resistance
KW  - antibody-drug conjugates
N2  - Aryl hydrocarbon receptor (AhR) is a transcription factor that is primarily known as an intracellular sensor of environmental pollution. After five decades, the list of synthetic and toxic chemicals that activate AhR signaling has been extended to include a number of endogenous compounds produced by various types of cells via their metabolic activity. AhR signaling is active from the very beginning of embryonal development throughout the life cycle and participates in numerous biological processes such as control of cell proliferation and differentiation, metabolism of aromatic compounds of endogenous and exogenous origin, tissue regeneration and stratification, immune system development and polarization, control of stemness potential, and homeostasis maintenance. AhR signaling can be affected by various pharmaceuticals that may help modulate abnormal AhR signaling and drive pathological states. Given their role in immune system development and regulation, AhR antagonistic ligands are attractive candidates for immunotherapy of disease states such as advanced prostate cancer, where an aberrant immune microenvironment contributes to cancer progression and needs to be reeducated. Advanced stages of prostate cancer are therapeutically challenging and characterized by decreased overall survival (OS) due to the metastatic burden. Therefore, this review addresses the role of AhR signaling in the development and progression of prostate cancer and discusses the potential of AhR as a drug target for the treatment of advanced prostate cancer upon entering the phase of drug resistance and failure of first-line androgen deprivation therapy.Abbreviation: ADC: antibody-drug conjugate; ADT: androgen deprivation therapy; AhR: aryl hydrocarbon receptor; AR: androgen receptor; ARE: androgen response element; ARPI: androgen receptor pathway inhibitor; mCRPC: metastatic castration-resistant prostate cancer; DHT: 5a-dihydrotestosterone; FICZ: 6-formylindolo[3,2-b]carbazole; 3-MC: 3-methylcholanthrene; 6-MCDF: 6-methyl-1,3,8-trichlorodibenzofuran; MDSCs: myeloid-derived suppressor cells; PAHs: polycyclic aromatic hydrocarbons; PCa: prostate cancer; TAMs: tumor-associated macrophages; TF: transcription factor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TME: tumor microenvironment; TRAMP: transgenic adenocarcinoma of the mouse prostate; TROP2: tumor associated calcium signal transducer 2
ER  -

PROCHÁZKOVÁ, Jiřina, Zuzana KAHOUNOVA, Jan VONDRÁČEK a Karel SOUČEK. Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives. \textit{TRANSCRIPTION-AUSTIN}. UNITED STATES: TAYLOR \&{} FRANCIS INC, 2024, 20 s. ISSN~2154-1264. Dostupné z: https://dx.doi.org/10.1080/21541264.2024.2334106.

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