Další formáty:
BibTeX
LaTeX
RIS
@article{2398038,
author = {Hubacek, Jaroslav A. and Philipp, Tom and Májek, Ondřej and Dlouha, Dana and Adamkova, Vera and Dušek, Ladislav},
article_location = {Prague},
article_number = {5-6},
doi = {http://dx.doi.org/10.14712/fb2023069050181},
keywords = {COVID-19; CD14; polymorphism; SARS-CoV-2},
language = {eng},
issn = {0015-5500},
journal = {Folia biologica},
title = {CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population},
url = {https://fb.littledata.cz/69/5/0181/},
volume = {69},
year = {2023}
}
TY - JOUR
ID - 2398038
AU - Hubacek, Jaroslav A. - Philipp, Tom - Májek, Ondřej - Dlouha, Dana - Adamkova, Vera - Dušek, Ladislav
PY - 2023
TI - CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population
JF - Folia biologica
VL - 69
IS - 5-6
SP - 181-185
EP - 181-185
PB - Charles University
SN - 00155500
KW - COVID-19
KW - CD14
KW - polymorphism
KW - SARS-CoV-2
UR - https://fb.littledata.cz/69/5/0181/
N2 - A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C -> T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case -control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering codominant and recessive genetic models or various between -group comparisons. The CD14 polymor phism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.
ER -
HUBACEK, Jaroslav A., Tom PHILIPP, Ondřej MÁJEK, Dana DLOUHA, Vera ADAMKOVA a Ladislav DUŠEK. CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population. \textit{Folia biologica}. Prague: Charles University, 2023, roč.~69, 5-6, s.~181-185. ISSN~0015-5500. Dostupné z: https://dx.doi.org/10.14712/fb2023069050181.
|
