Glutathione S-transferase M1, T1, and P1 polymorphisms and
periodontitis in a Caucasian population: a case-control study

J 2024

Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study

IZAKOVIČOVÁ, Pavla, Antonín FASSMANN, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ

Základní údaje

Originální název

Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study

Autoři

IZAKOVIČOVÁ, Pavla (203 Česká republika, domácí), Antonín FASSMANN (203 Česká republika, domácí), Ladislav DUŠEK (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, domácí)

Vydání

BMC Oral Health, London, BMC, 2024, 1472-6831

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.900 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/s12903-024-04034-x

UT WoS

001177861200002

Klíčová slova anglicky

Gene; Glutathione S-transferase; GSTs; Periodontitis; Polymorphism

Štítky

14110130, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 5. 2024 08:42, Mgr. Tereza Miškechová

Anotace

V originále

Background Glutathione S-transferases (GSTs) play important roles in protecting cells against oxidative stress and toxic chemicals. This study aimed to investigate the distribution of GSTM1, GSTT1, and GSTP1 variants and their roles in periodontitis susceptibility in a Caucasian population. Methods We analyzed 406 participants, including 204 healthy controls and 203 periodontitis patients. A multiplex polymerase chain reaction (PCR) approach was used to analyze GSTM1 and GSTT1 loci. GSTP1 variants were detected by PCR-haplotyping method in a subgroup of participants (N = 350). Chi-square or Fishers exact tests were used to compare genotypic and allelic differences. The Bonferroni method was applied to correct for multiple comparisons (p(corr)). Results The GSTM1 genotype distribution did not differ significantly between controls and periodontitis patients (p = 0.44). Additionally, the wild/null genotypes of GSTT1, Ile105Val and Ala114Val frequencies of GSTP1 were not significantly different between the two groups after correction for multiple comparisons (p = 0.05, p = 0.55, p = 0.02, p(corr)>0.05, respectively). The GSTM1 and GSTP1 Ile105Val gene variants were similarly distributed between non-smokers and smokers in both groups (p = 0.38, p = 0.20, and p = 0.14, p = 0.35, respectively). However, the wild genotype of the GSTT1 and Ala114Ala variant of the GSTP1 genes were present more frequently in non-smoking periodontitis patients than in non-smoking controls (p = 0.03, p(corr)>0.05, and p = 0.009, p(corr)>0.05, respectively) although their frequencies did not differ between smoking periodontitis patients and smoking controls (p = 0.23, p = 0.68, respectively). Conclusions This study in a Czech Caucasian population did not confirm a highly significant association between GST gene variants and susceptibility to periodontitis, as previously reported by Arshad and colleagues in Pakistanis. However, a weak relationship between GSTT1 and GSTP1 rs1138272 polymorphisms and periodontitis in non-smokers was observed.

Návaznosti

MUNI/A/1607/2023, interní kód MU

Název: Diagnostika a léčba vybraných chorob dutiny ústní

Investor: Masarykova univerzita, Diagnostika a léčba vybraných chorob dutiny ústní

Citovat

IZAKOVIČOVÁ, Pavla, Antonín FASSMANN, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study. BMC Oral Health. London: BMC, 2024, roč. 24, č. 1, s. 1-7. ISSN 1472-6831. Dostupné z: https://dx.doi.org/10.1186/s12903-024-04034-x.

@article{2398778,
   author = {Izakovičová, Pavla and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12903-024-04034-x},
   keywords = {Gene; Glutathione S-transferase; GSTs; Periodontitis; Polymorphism},
   language = {eng},
   issn = {1472-6831},
   journal = {BMC Oral Health},
   title = {Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study},
   url = {https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-024-04034-x},
   volume = {24},
   year = {2024}
}

TY  - JOUR
ID  - 2398778
AU  - Izakovičová, Pavla - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY  - 2024
TI  - Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study
JF  - BMC Oral Health
VL  - 24
IS  - 1
SP  - 1-7
EP  - 1-7
PB  - BMC
SN  - 14726831
KW  - Gene
KW  - Glutathione S-transferase
KW  - GSTs
KW  - Periodontitis
KW  - Polymorphism
UR  - https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-024-04034-x
N2  - Background Glutathione S-transferases (GSTs) play important roles in protecting cells against oxidative stress and toxic chemicals. This study aimed to investigate the distribution of GSTM1, GSTT1, and GSTP1 variants and their roles in periodontitis susceptibility in a Caucasian population. Methods We analyzed 406 participants, including 204 healthy controls and 203 periodontitis patients. A multiplex polymerase chain reaction (PCR) approach was used to analyze GSTM1 and GSTT1 loci. GSTP1 variants were detected by PCR-haplotyping method in a subgroup of participants (N = 350). Chi-square or Fishers exact tests were used to compare genotypic and allelic differences. The Bonferroni method was applied to correct for multiple comparisons (p(corr)). Results The GSTM1 genotype distribution did not differ significantly between controls and periodontitis patients (p = 0.44). Additionally, the wild/null genotypes of GSTT1, Ile105Val and Ala114Val frequencies of GSTP1 were not significantly different between the two groups after correction for multiple comparisons (p = 0.05, p = 0.55, p = 0.02, p(corr)>0.05, respectively). The GSTM1 and GSTP1 Ile105Val gene variants were similarly distributed between non-smokers and smokers in both groups (p = 0.38, p = 0.20, and p = 0.14, p = 0.35, respectively). However, the wild genotype of the GSTT1 and Ala114Ala variant of the GSTP1 genes were present more frequently in non-smoking periodontitis patients than in non-smoking controls (p = 0.03, p(corr)>0.05, and p = 0.009, p(corr)>0.05, respectively) although their frequencies did not differ between smoking periodontitis patients and smoking controls (p = 0.23, p = 0.68, respectively). Conclusions This study in a Czech Caucasian population did not confirm a highly significant association between GST gene variants and susceptibility to periodontitis, as previously reported by Arshad and colleagues in Pakistanis. However, a weak relationship between GSTT1 and GSTP1 rs1138272 polymorphisms and periodontitis in non-smokers was observed.
ER  -

IZAKOVIČOVÁ, Pavla, Antonín FASSMANN, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study. \textit{BMC Oral Health}. London: BMC, 2024, roč.~24, č.~1, s.~1-7. ISSN~1472-6831. Dostupné z: https://dx.doi.org/10.1186/s12903-024-04034-x.

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