Cross sectional study on exposure to BPA and its analogues and
semen parameters in Czech men

J 2024

Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men

JEŠETA, Michal; Jiří KALINA; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Jan HOŠEK et al.

Základní údaje

Originální název

Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men

Autoři

JEŠETA, Michal; Jiří KALINA; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Jan HOŠEK ; Lenka MEKIŇOVÁ; Igor CRHA; Bartosz KEMPISTY; Pavel VENTRUBA a Jana NAVRÁTILOVÁ

Vydání

Environmental Pollution, OXFORD, ELSEVIER SCI LTD, 2024, 0269-7491

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.300

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00135941

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Bisphenols; Endocrine disruptors; Human; Spermatozoa; IVF

Štítky

14110240, 14110611, 143180, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 4. 2025 12:10, Mgr. Tereza Miškechová

Anotace

V originále

Exposure to bisphenols has been found to have adverse effects on male reproductive function in animals. Human exposure to bisphenols is widespread. Bisphenol A (BPA) and its analogues, including bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF) are utilized in various consumer products such as food contact materials and dental resins. The effects of these compounds on male fertility and spermatogenesis are unclear and findings from human studies are inconsistent. In this cross-sectional study, we evaluated the influence of BPA, BPS, BPF, BPAF (BPs) measured in semen on number of spermatozoa, total motility, progressive motility, morphology, and DNA fragmentation. We also examined the association of bisphenols (BPs) exposure with patients' occupation. A total of 358 patients aged 17-62 years with BMI 18-42 were included in the study from 2019 to 2021. BPs were extracted using solvent extraction followed by preconcentration step and determined by high-performance liquid chromatography and tandem mass spectrometry (LC/MSMS). Bisphenols were detected in 343 from 349 analysed samples (98.3% of all the samples). In 6 samples, the concentration of all BPs was under the limit of detection and in 20 samples under the limit of quantification. We did not find a statistically significant relationship between occupation and BPs. However, we observed significant correlations between the concentration of BPA and a lower motility and normal morphology. For BPS, a significant correlation with a lower ejaculate volume and a lower total sperm count was found. BPF and BPAF were detected only in 14.3% and 23.9% of samples, respectively. For BPF and BPAF, no significant correlations with spermiogram parameters were observed. Our results show that BPs are widespread in the male population (more than 90% of analysed samples), independently of an occupation and in case of BPA and BPS having a negative impact on spermiogram parameters.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

EF19_074/0012727, projekt VaV

Název: MSCAfellow3@MUNI

101003355, interní kód MU

Název: Investigation of the effects of per- and polyfluoroalkyl substances on reproductive health in the fire-fighting environment (Akronym: INFERNO)

Investor: Evropská unie, Investigation of the effects of per- and polyfluoroalkyl substances on reproductive health in the fire-fighting environment, Spreading excellence and widening participation

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90269, velká výzkumná infrastruktura

Název: RECETOX RI II

Přiložené soubory

2398868.pdf

Citovat

JEŠETA, Michal; Jiří KALINA; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Jan HOŠEK; Lenka MEKIŇOVÁ; Igor CRHA; Bartosz KEMPISTY; Pavel VENTRUBA a Jana NAVRÁTILOVÁ. Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men. Environmental Pollution. OXFORD: ELSEVIER SCI LTD, 2024, roč. 345, March 2024, s. 1-9. ISSN 0269-7491. Dostupné z: https://doi.org/10.1016/j.envpol.2024.123445.

@article{2398868,
   author = {Ješeta, Michal and Kalina, Jiří and Franzová, Kateřina and Fialková, Sandra and Hošek, Jan and Mekiňová, Lenka and Crha, Igor and Kempisty, Bartosz and Ventruba, Pavel and Navrátilová, Jana},
   article_location = {OXFORD},
   article_number = {March 2024},
   doi = {https://doi.org/10.1016/j.envpol.2024.123445},
   keywords = {Bisphenols; Endocrine disruptors; Human; Spermatozoa; IVF},
   language = {eng},
   issn = {0269-7491},
   journal = {Environmental Pollution},
   title = {Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men},
   url = {https://www.sciencedirect.com/science/article/pii/S0269749124001593?via%3Dihub},
   volume = {345},
   year = {2024}
}

TY  - JOUR
ID  - 2398868
AU  - Ješeta, Michal - Kalina, Jiří - Franzová, Kateřina - Fialková, Sandra - Hošek, Jan - Mekiňová, Lenka - Crha, Igor - Kempisty, Bartosz - Ventruba, Pavel - Navrátilová, Jana
PY  - 2024
TI  - Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men
JF  - Environmental Pollution
VL  - 345
IS  - March 2024
SP  - 1-9
EP  - 1-9
PB  - ELSEVIER SCI LTD
SN  - 02697491
KW  - Bisphenols
KW  - Endocrine disruptors
KW  - Human
KW  - Spermatozoa
KW  - IVF
UR  - https://www.sciencedirect.com/science/article/pii/S0269749124001593?via%3Dihub
N2  - Exposure to bisphenols has been found to have adverse effects on male reproductive function in animals. Human exposure to bisphenols is widespread. Bisphenol A (BPA) and its analogues, including bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF) are utilized in various consumer products such as food contact materials and dental resins. The effects of these compounds on male fertility and spermatogenesis are unclear and findings from human studies are inconsistent. In this cross-sectional study, we evaluated the influence of BPA, BPS, BPF, BPAF (BPs) measured in semen on number of spermatozoa, total motility, progressive motility, morphology, and DNA fragmentation. We also examined the association of bisphenols (BPs) exposure with patients' occupation. A total of 358 patients aged 17-62 years with BMI 18-42 were included in the study from 2019 to 2021. BPs were extracted using solvent extraction followed by preconcentration step and determined by high-performance liquid chromatography and tandem mass spectrometry (LC/MSMS). Bisphenols were detected in 343 from 349 analysed samples (98.3% of all the samples). In 6 samples, the concentration of all BPs was under the limit of detection and in 20 samples under the limit of quantification. We did not find a statistically significant relationship between occupation and BPs. However, we observed significant correlations between the concentration of BPA and a lower motility and normal morphology. For BPS, a significant correlation with a lower ejaculate volume and a lower total sperm count was found. BPF and BPAF were detected only in 14.3% and 23.9% of samples, respectively. For BPF and BPAF, no significant correlations with spermiogram parameters were observed. Our results show that BPs are widespread in the male population (more than 90% of analysed samples), independently of an occupation and in case of BPA and BPS having a negative impact on spermiogram parameters.
ER  -

JEŠETA, Michal; Jiří KALINA; Kateřina FRANZOVÁ; Sandra FIALKOVÁ; Jan HOŠEK; Lenka MEKIŇOVÁ; Igor CRHA; Bartosz KEMPISTY; Pavel VENTRUBA a Jana NAVRÁTILOVÁ. Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men. \textit{Environmental Pollution}. OXFORD: ELSEVIER SCI LTD, 2024, roč.~345, March 2024, s.~1-9. ISSN~0269-7491. Dostupné z: https://doi.org/10.1016/j.envpol.2024.123445.

Přehled o publikaci