Microstructure-properties relation of hydrostatically extruded
absorbable zinc alloys: Effect of Mg and Cu addition on
corrosion properties and biocompatibility

J 2024

Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility

JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA et. al.

Základní údaje

Originální název

Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility

Autoři

Vydání

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, AMSTERDAM, ELSEVIER, 2024, 2238-7854

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30404 Biomaterials

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.400 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jmrt.2024.03.044

UT WoS

001224411800001

Klíčová slova anglicky

Absorbable zinc alloys; Hydrostatic extrusion; Corrosion behavior; Cytotoxicity of zinc alloys

Štítky

14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 6. 2024 09:36, Mgr. Tereza Miškechová

Anotace

V originále

Pure Zn is well-known for its appropriate corrosion rate, making it suitable for use as future absorbable implants. Yet, it suffers from insufficient strength, thus, both plastic deformation and alloying are required. Hydrostatic extrusion has proven to be an efficient technique, providing high mechanical properties for zinc alloys. However, its effect on degradation rate and biocompatibility of Zn alloys remains unknown. Thus, within the present study, an attempt to evaluate those properties has been made on hydrostatically extruded pure Zn, Zn–Mg and Zn–Mg–Cu alloys. The materials were characterized by advanced microscopy techniques and uniaxial tensile tests. Corrosion properties were assessed based on electrochemical and static immersion tests. Finally, the cytotoxic effect of zinc extracts on endothelial cells were examined by standard MTT assays combined with confocal imaging. The results showed that hydrostatic extrusion results in significant refinement of α-Zn grains and the intermetallic phase Mg2Zn11 for the investigated alloys. The alloys exhibited ultimate tensile strength exceeding 300 MPa and elongation higher than 20%. Corrosion tests demonstrated that all the materials showed a similar level of degradation rate. Moreover, the uniform distribution of the intermetallic phase contributed to homogeneous corrosion of Zn alloys. Biological studies indicated that the least cytotoxic response in endothelial cells was obtained for the Zn–Mg alloy. Such an effect was caused by the limited amount of released Zn ions in the favor of Mg ions. The refinement of α-Zn grains and intermetallic phases caused by hydrostatic extrusion were key factors determining the performance of Zn-based materials.

Citovat

JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA, Monika BUGAJSKA, Magdalena BIEDA, Łukasz ROGAL, Jakub KAWAŁKO, Sylwia PRZYBYSZ, Daniel WOJTAS, Aldona MZYK a Romana SCHIRHAGL. Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T. AMSTERDAM: ELSEVIER, 2024, roč. 30, May-June 2024, s. 283-294. ISSN 2238-7854. Dostupné z: https://dx.doi.org/10.1016/j.jmrt.2024.03.044.

@article{2401678,
   author = {Jarzębska, Anna and Gieleciak, Magdalena and Bigos, Agnieszka and Maj, Łukasz and TrembeckaandWojciga, Klaudia and Bugajska, Monika and Bieda, Magdalena and Rogal, Łukasz and Kawałko, Jakub and Przybysz, Sylwia and Wojtas, Daniel and Mzyk, Aldona and Schirhagl, Romana},
   article_location = {AMSTERDAM},
   article_number = {May-June 2024},
   doi = {http://dx.doi.org/10.1016/j.jmrt.2024.03.044},
   keywords = {Absorbable zinc alloys; Hydrostatic extrusion; Corrosion behavior; Cytotoxicity of zinc alloys},
   language = {eng},
   issn = {2238-7854},
   journal = {JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T},
   title = {Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility},
   url = {https://www.sciencedirect.com/science/article/pii/S2238785424005726?via%3Dihub},
   volume = {30},
   year = {2024}
}

TY  - JOUR
ID  - 2401678
AU  - Jarzębska, Anna - Gieleciak, Magdalena - Bigos, Agnieszka - Maj, Łukasz - Trembecka-Wojciga, Klaudia - Bugajska, Monika - Bieda, Magdalena - Rogal, Łukasz - Kawałko, Jakub - Przybysz, Sylwia - Wojtas, Daniel - Mzyk, Aldona - Schirhagl, Romana
PY  - 2024
TI  - Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility
JF  - JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
VL  - 30
IS  - May-June 2024
SP  - 283-294
EP  - 283-294
PB  - ELSEVIER
SN  - 22387854
KW  - Absorbable zinc alloys
KW  - Hydrostatic extrusion
KW  - Corrosion behavior
KW  - Cytotoxicity of zinc alloys
UR  - https://www.sciencedirect.com/science/article/pii/S2238785424005726?via%3Dihub
N2  - Pure Zn is well-known for its appropriate corrosion rate, making it suitable for use as future absorbable implants. Yet, it suffers from insufficient strength, thus, both plastic deformation and alloying are required. Hydrostatic extrusion has proven to be an efficient technique, providing high mechanical properties for zinc alloys. However, its effect on degradation rate and biocompatibility of Zn alloys remains unknown. Thus, within the present study, an attempt to evaluate those properties has been made on hydrostatically extruded pure Zn, Zn–Mg and Zn–Mg–Cu alloys. The materials were characterized by advanced microscopy techniques and uniaxial tensile tests. Corrosion properties were assessed based on electrochemical and static immersion tests. Finally, the cytotoxic effect of zinc extracts on endothelial cells were examined by standard MTT assays combined with confocal imaging. The results showed that hydrostatic extrusion results in significant refinement of α-Zn grains and the intermetallic phase Mg2Zn11 for the investigated alloys. The alloys exhibited ultimate tensile strength exceeding 300 MPa and elongation higher than 20%. Corrosion tests demonstrated that all the materials showed a similar level of degradation rate. Moreover, the uniform distribution of the intermetallic phase contributed to homogeneous corrosion of Zn alloys. Biological studies indicated that the least cytotoxic response in endothelial cells was obtained for the Zn–Mg alloy. Such an effect was caused by the limited amount of released Zn ions in the favor of Mg ions. The refinement of α-Zn grains and intermetallic phases caused by hydrostatic extrusion were key factors determining the performance of Zn-based materials.
ER  -

JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA, Monika BUGAJSKA, Magdalena BIEDA, Łukasz ROGAL, Jakub KAWAŁKO, Sylwia PRZYBYSZ, Daniel WOJTAS, Aldona MZYK a Romana SCHIRHAGL. Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility. \textit{JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR\&{}T}. AMSTERDAM: ELSEVIER, 2024, roč.~30, May-June 2024, s.~283-294. ISSN~2238-7854. Dostupné z: https://dx.doi.org/10.1016/j.jmrt.2024.03.044.

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