J 2024

Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility

JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA et. al.

Základní údaje

Originální název

Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility

Autoři

JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA, Monika BUGAJSKA, Magdalena BIEDA, Łukasz ROGAL, Jakub KAWAŁKO, Sylwia PRZYBYSZ, Daniel WOJTAS (616 Polsko, domácí), Aldona MZYK a Romana SCHIRHAGL

Vydání

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, AMSTERDAM, ELSEVIER, 2024, 2238-7854

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30404 Biomaterials

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 6.400 v roce 2022

Organizační jednotka

Lékařská fakulta

UT WoS

001224411800001

Klíčová slova anglicky

Absorbable zinc alloys; Hydrostatic extrusion; Corrosion behavior; Cytotoxicity of zinc alloys

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 4. 6. 2024 09:36, Mgr. Tereza Miškechová

Anotace

V originále

Pure Zn is well-known for its appropriate corrosion rate, making it suitable for use as future absorbable implants. Yet, it suffers from insufficient strength, thus, both plastic deformation and alloying are required. Hydrostatic extrusion has proven to be an efficient technique, providing high mechanical properties for zinc alloys. However, its effect on degradation rate and biocompatibility of Zn alloys remains unknown. Thus, within the present study, an attempt to evaluate those properties has been made on hydrostatically extruded pure Zn, Zn–Mg and Zn–Mg–Cu alloys. The materials were characterized by advanced microscopy techniques and uniaxial tensile tests. Corrosion properties were assessed based on electrochemical and static immersion tests. Finally, the cytotoxic effect of zinc extracts on endothelial cells were examined by standard MTT assays combined with confocal imaging. The results showed that hydrostatic extrusion results in significant refinement of α-Zn grains and the intermetallic phase Mg2Zn11 for the investigated alloys. The alloys exhibited ultimate tensile strength exceeding 300 MPa and elongation higher than 20%. Corrosion tests demonstrated that all the materials showed a similar level of degradation rate. Moreover, the uniform distribution of the intermetallic phase contributed to homogeneous corrosion of Zn alloys. Biological studies indicated that the least cytotoxic response in endothelial cells was obtained for the Zn–Mg alloy. Such an effect was caused by the limited amount of released Zn ions in the favor of Mg ions. The refinement of α-Zn grains and intermetallic phases caused by hydrostatic extrusion were key factors determining the performance of Zn-based materials.