2024
Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility
JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA et. al.Základní údaje
Originální název
Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility
Autoři
JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA, Monika BUGAJSKA, Magdalena BIEDA, Łukasz ROGAL, Jakub KAWAŁKO, Sylwia PRZYBYSZ, Daniel WOJTAS (616 Polsko, domácí), Aldona MZYK a Romana SCHIRHAGL
Vydání
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, AMSTERDAM, ELSEVIER, 2024, 2238-7854
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30404 Biomaterials
Stát vydavatele
Nizozemské království
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 6.400 v roce 2022
Organizační jednotka
Lékařská fakulta
UT WoS
001224411800001
Klíčová slova anglicky
Absorbable zinc alloys; Hydrostatic extrusion; Corrosion behavior; Cytotoxicity of zinc alloys
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 4. 6. 2024 09:36, Mgr. Tereza Miškechová
Anotace
V originále
Pure Zn is well-known for its appropriate corrosion rate, making it suitable for use as future absorbable implants. Yet, it suffers from insufficient strength, thus, both plastic deformation and alloying are required. Hydrostatic extrusion has proven to be an efficient technique, providing high mechanical properties for zinc alloys. However, its effect on degradation rate and biocompatibility of Zn alloys remains unknown. Thus, within the present study, an attempt to evaluate those properties has been made on hydrostatically extruded pure Zn, Zn–Mg and Zn–Mg–Cu alloys. The materials were characterized by advanced microscopy techniques and uniaxial tensile tests. Corrosion properties were assessed based on electrochemical and static immersion tests. Finally, the cytotoxic effect of zinc extracts on endothelial cells were examined by standard MTT assays combined with confocal imaging. The results showed that hydrostatic extrusion results in significant refinement of α-Zn grains and the intermetallic phase Mg2Zn11 for the investigated alloys. The alloys exhibited ultimate tensile strength exceeding 300 MPa and elongation higher than 20%. Corrosion tests demonstrated that all the materials showed a similar level of degradation rate. Moreover, the uniform distribution of the intermetallic phase contributed to homogeneous corrosion of Zn alloys. Biological studies indicated that the least cytotoxic response in endothelial cells was obtained for the Zn–Mg alloy. Such an effect was caused by the limited amount of released Zn ions in the favor of Mg ions. The refinement of α-Zn grains and intermetallic phases caused by hydrostatic extrusion were key factors determining the performance of Zn-based materials.