Changes of serum protein N-glycosylation in cancer

BENEŠOVÁ, Iva, Adam Paulin URMINSKÝ, Jana HALÁMKOVÁ a Lenka HERNYCHOVÁ. Changes of serum protein N-glycosylation in cancer. Časopis Klinická onkologie. Praha: Česká lékařská společnost J. E. Purkyně, 2022, roč. 35, č. 3, s. 174-180. ISSN 0862-495X. Dostupné z: https://dx.doi.org/10.48095/ccko2022174.

Základní údaje

• Originální název: Changes of serum protein N-glycosylation in cancer
• Autoři: BENEŠOVÁ, Iva, Adam Paulin URMINSKÝ, Jana HALÁMKOVÁ a Lenka HERNYCHOVÁ.
• Vydání: Časopis Klinická onkologie, Praha, Česká lékařská společnost J. E. Purkyně, 2022, 0862-495X.

Další údaje

• Typ výsledku: Článek v odborném periodiku
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Doi: http://dx.doi.org/10.48095/ccko2022174
• Klíčová slova anglicky: glycommics; glycoproteomics; N-glycans; N-glycan profiling; glycopeptides; serum proteins;, mass spectrometry

Anotace

Glycosylation is a posttranslantional modification responsible for many biological processes including protein-protein interactions, cell signaling or cell cycle regulation. Changes in glycosylation of serum proteins reflects the status od tissues and cells in the organism and therefore can be used as markers for diagnosis of cancer, its progression and determination of its subtypes. N-glycan profiling is often used for characterization of N- glycosylation changes. It is based on the measurements of N-glycans released from the serum proteins. Beside the N-glycan profiling, glycoproteomic approach is emerging as it preserves the information about glycan composition, original protein, and its glycosylation sites. Purpose: This review covers existing works describing the changes in serum protein N-glycosylation in various cancer types. Attention was paid to both the glycomic and glycoproteomic approaches. The last part of the review shortly presents the analytical methods used for these analyses.